Chemistry

Difference Between Thiamine Mononitrate and Thiamine Hydrochloride

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Main Difference

The main difference between Thiamine Mononitrate and Thiamine Hydrochloride is that Thiamine mononitrate is generally considered as non-hygroscopic, whereas Thiamine Hydrochloride is usually found as hygroscopic.

Thiamine Mononitrate vs. Thiamine Hydrochloride

The method of vitamin B1, which is stable synthetic nitrate is thiamine mononitrate, while vitamin B1 hydrochloride is considered as thiamine hydrochloride. The chemical formula of thiamine mononitrate is generally written as C12H17N5O4S, whereas the thiamine hydrochloride is chemically written as HC12H17ON4SCl2. 327.36g/mole is usually the calculated molar mass of thiamine nitrate; on the hand, the calculated molar mass of thiamine hydrochloride is 337.263g/mole.

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Thiamine mononitrate is typically reviewed as non-hygroscopic; on the contrary, thiamine hydrochloride is usually identified as hygroscopic. The nitrate ion is the anion which is generally present in the structure of thiamine mononitrate; on the flip side, the chloride ion is the anion that is usually present in the structure of thiamine hydrochloride.

Thiamine mononitrate is usually considered as more stable than thiamine hydrochloride, while thiamine hydrochloride is normally less stable than thiamine mononitrate. Thiamine nitrate is taken in the body via feed, whereas thiamine hydrochloride is taken in the body via water.

Comparison Chart

Thiamine MononitrateThiamine Hydrochloride
The process of vitamin B1, which is steady synthetic nitrate, is known as thiamine mononitrate.Vitamin B1 hydrochloride is generally known as thiamine hydrochloride.
Chemical Formula
C12H17N5O4SHC12H17ON4SCl2
Molar Mass
327.36g/mole337.263g/mole
Forms of Vitamin B1
The form of vitamin B1 which is stable synthetic nitrateVitamin B1 hydrochloride form is thiamine hydrochloride
Hygroscopy
Non-hygroscopicHygroscopic
Anion
Nitrate ionChloride ion
Stability
More stableLess stable
Methods of Taking
Taken in the body via feedTaken in the body via water
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What is Thiamine Mononitrate?

Vitamin B1 nitrate is normally also known as thiamine nitrate, and thiamine nitrate formula is chemically written as C12H17N5O4S. The thiamine mononitrate is the method of vitamin B1, which is a stable synthetic nitrate. 327.36g/mole is usually the calculated molar mass of thiamine nitrate. The IUPAC name of this vitamin B1 nitrate is written as 3-[(4-amino-2-methyl pyrimidine-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl thiazolium nitrate.

Thiamine hydrochloride is the main cause of making thiamine mononitrate, which is prepared by removing the anion chloride ion of thiamine hydrochloride and then mixing it with nitrate ion anion. After this, the nitrate ion normally associates with the thiamine compound. That’s why thiamine mononitrate is usually considered as a synthetic compound. It has many pros, but its cons are also discussed in which it can be mild to severe allergic reactions in the human body when taken in the body via feeding, this is due to the impurities present in synthetic vitamins than which are not present in natural ones.

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However, low levels of thiamine nitrate in the human body can cause severe kidney problems, a high level of thiamine nitrate whose anion, nitrate ion may collect in the kidneys by forming insoluble nitrate compounds which produce kidney stones. Thiamine mononitrate is generally used as food additives and for the multivitamin preparations taken by humans because it is more stable than thiamine hydrochloride, and it is hygroscopic, which means the water absorptivity of thiamine mononitrate is very low. Thiamine mononitrate is very safe for use as a food additive because the nitrates ion removed after dissolving in water, and then only thiamine will be left for absorbing in blood.

What is Thiamine Hydrochloride?

Vitamin B1 hydrochloride is considered as thiamine hydrochloride, and the thiamine hydrochloride is chemically written as HC12H17ON4SCl2. The calculated molar mass of thiamine hydrochloride is 337.263g/mole. The IUPAC name of thiamine hydrochloride, which is given is 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl thiazolium chloride. Thiamine hydrochloride is normally considered as the hydrochloride kind of thiamine (vitamin B1).

Thiamine hydrochloride is generally a salt that is made of cation and anion. The anion of thiamine hydrochloride is the chloride ion, which is generally available as in crystal structure and has a minor scent. Thiamine hydrochloride is usually soluble in water and then produces a colorless clear aqueous solution in water.

Thiamine hydrochloride is usually found as hygroscopic because when it exposed to the outer environment, it can absorb all the water. Thiamine hydrochloride emits toxic gases, for instance, sulfur oxide, nitric oxide, etc. when heated in high temperature at approximately 250 ֯C.

Thiamine hydrochloride cannot be taken via feeding but taken via water, which performs many essential functions in human bodies such as cell growth, acetylcholine synthesis, aerobic metabolism of humans, and many more. Thiamine hydrochloride also eye and skin allergic reactions in the human body when taken, but thiamine hydrochloride are considered an effective source of vitamin B1.

Key Differences

  1. Thiamine mononitrate is the process of vitamin B1, which is considered as a stable synthetic nitrate, while vitamin B1 hydrochloride is considered as thiamine hydrochloride.
  2. C12H17N5O4S is the chemical formula of thiamine nitrate, whereas HC12H17ON4SCl2 is the chemical formula of thiamine chloride.
  3. The molar mass of thiamine nitrate is usually calculated as 327.36g/mole; on the hand, the molar mass of thiamine hydrochloride is calculated as 337.263g/mole.
  4. Thiamine mononitrate is also known as non-hygroscopic; on the contrary, thiamine hydrochloride is commonly known as hygroscopic.
  5. In the structure of thiamine mononitrate, the nitrate ion, which is considered as anion is generally present; on the flip side, in the structure of thiamine hydrochloride, the chloride ion is usually the anion that is commonly present.
  6. Thiamine mononitrate is usually deliberated as extra established than thiamine hydrochloride, while thiamine hydrochloride is usually fewer established than thiamine mononitrate.
  7. Thiamine nitrate is in use in the body through the feed, whereas thiamine hydrochloride is in use in the body through water.

Conclusion

The above discussion concludes that the thiamine mononitrate is generally categorized as non-hygroscopic and taken in the body via feed, whereas thiamine hydrochloride is usually categorized as hygroscopic, but taken in the body via water.

Harlon Moss

Harlon currently works as a quality moderator and content writer for Difference Wiki. He graduated from the University of California in 2010 with a degree in Computer Science. Follow him on Twitter @HarlonMoss

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