Vesicle vs. Vacuole
The main difference between Vesicle and Vacuole is that Vesicle made to store many different kinds of molecules, whereas Vacuole is one of the kinds of a vesicle, store mostly water.

Key Differences
The size of the vesicle is small as compared to the vacuole, which is comparatively larger.
Many nutrient molecules, enzymes, water, wastes, harmful substances, and many ions compose the vesicles; on the other hand, water is the main component that composes the vacuole.
The vesicle is found only in eukaryotic cells, while both prokaryotic and eukaryotic cells consist of the vacuole.
A vesicle is known as a small, chemically neutral, membrane-bounded, and a temporary container as well, which used to pass its contents across organelles and cell plasma membranes. In contrast, a vacuole is larger, a membranous bound organelle, found in plant and fungal cells, and many bacterial, animal, and protist cells.
Different most common types of the vesicle are transport vesicles, secretory vesicles, extracellular vesicles, vacuoles, and lysosomes; however, many bacteria, fungi, plant and animal cells contain vacuoles.
The number of vesicles present in a cell is higher as compared to the number of vacuoles present in a cell because they are present in a lower number.
Vesicle is mainly involved in temporary loading of food and enzymes, buoyancy control, transport of the molecules, metabolism, and also in the chemical reaction compartments; on the flip side, vacuole is mainly involved in the structural supporting of the cell, and as well as in the storing of water and many other substances.
Comparison Chart
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A vesicle is a supramolecular association of lipid molecules like a membrane of the cell
A vacuole is considered a membrane-bounded organelle, which found in all plants, animals, fungi, and some protists
Consists Of
Consists of different types of fluid
Consists of mostly water
Size
Usually small in size
Relatively larger as compared to the vesicle
Presence
Present in all eukaryotic cells
Present in both prokaryotic and eukaryotic cells
Composition
Made up of many nutrients, enzymes, water, wastes, harmful compounds, and ions
Mainly made up of water
Role
The main role is that it is involved in breakdown, temporary storage of food substances and enzymes, buoyancy control and transport molecules to different parts of the cell, and they also serve as a chemical reaction chamber
The most important role is that it is involved in storing many substances containing mostly water, and it contributes to the structural support of the cell
Types
Many different types include lysosomes, vacuoles, secretory vesicles, transport vesicles, and extracellular vesicles
Many fungi, bacteria, plant and animal cells consist of vacuoles
Number Present
There is present a higher number of the vesicle is present in a cell
The number of vacuoles presents inside a cell is relatively lower than the number of vesicles present inside a cell.
Vesicle and Vacuole Definitions
Vesicle
(Cytology) A membrane-bound structure within a cell in which materials such as enzymes are transported or stored.
Vacuole
A membrane-bound organelle in the cytoplasm of most cells, especially plant cells, containing water and dissolved substances such as salts, sugars, enzymes, and amino acids.
Vesicle
(Anatomy) A sac or cyst, especially one containing fluid.
Vacuole
A small extracellular cavity or space within tissues.
Vesicle
(Medicine) A blister of the skin.
Vacuole
(cytology) A large membrane-bound vesicle in a cell's cytoplasm.
Vesicle
(Geology) A cavity formed in volcanic rock by entrapment of a gas bubble during solidification.
Vacuole
A small empty or air-filled space or vacuity.
Vesicle
(cytology) A membrane-bound compartment found in a cell.
Vacuole
A small air cell, or globular space, in the interior of organic cells, either containing air, or a pellucid watery liquid, or some special chemical secretions of the cell protoplasm.
Vesicle
A small bladder-like cell or cavity, as:
Vacuole
A tiny cavity filled with fluid in the cytoplasm of a cell
Vesicle
(botany) A small sac filled with juice, one of many constituting the pulp of a fruit such as an orange, lemon, or grapefruit.
Vesicle
A small sac or cyst or vacuole, especially one containing fluid. A blister formed in or beneath the skin, containing serum. A bleb.
Vesicle
(anatomy) A pocket of embryonic tissue that is the beginning of an organ.
Vesicle
(geology) A small cavity formed in volcanic rock by entrapment of a gas bubble during solidification.
Vesicle
A bladderlike vessel; a membranous cavity; a cyst; a cell.
Vesicle
A small bladderlike body in the substance of a vegetable, or upon the surface of a leaf.
Vesicle
A small, and more or less circular, elevation of the cuticle, containing a clear watery fluid.
Vesicle
A cavity or sac, especially one filled with fluid; as, the umbilical vesicle.
Vesicle
A small convex hollow prominence on the surface of a shell or a coral.
Vesicle
A small cavity, nearly spherical in form, and usually of the size of a pea or smaller, such as are common in some volcanic rocks. They are produced by the liberation of watery vapor in the molten mass.
Vesicle
A small anatomically normal sac or bladderlike structure (especially one containing fluid)
Vesicle vs. Vacuole
A vesicle is known as a membrane-enclosed small organelle that is present inside the cell, and it consists of many different types of fluid; on the other hand, a vacuole known as a type of vesicles which mostly consists of water. A vesicle is usually small in size, while a vacuole is relatively larger as compared to the vesicle.
A vesicle is present in all eukaryotic cells; on the contrary, the vacuole is present in both prokaryotic and eukaryotic cells. A vesicle made up of many nutrients, enzymes, water, wastes, harmful compounds, and ions; on the flip side, the vacuole mainly made up of water.
The main role of vesicle is that it is involved in breakdown, temporary storage of food substances and enzymes, buoyancy control and transport molecules to different parts of the cell, and they also serve as a chemical reaction chamber; on the other hand, the main role of vacuole is that it is involved in storing of many substances containing mostly water, and it contributes into the structural support of the cell.
Many different types of vesicles include lysosomes, vacuoles, secretory vesicles, transport vesicles, and extracellular vesicles; on the other hand, many fungi, bacteria, plant, and animal cells consist of vacuoles. There is a present a higher number of the vesicle is present in a cell; on the contrary, the number of vacuoles presents inside a cell is relatively lower than the number of vesicles present inside a cell.
What is Vesicle?
A membrane-bounded organelle that is present inside the cells containing many types of constituents is known as a vesicle. Vesicle contains different types of fluid, and they formed during exocytosis and endocytosis. Liposomes, on the other hand, are formed artificially.
The membrane is a phospholipid bilayer, which usually encloses the vesicle. The unilamellar liposomes consist of a single phospholipid bilayer that surrounds the vesicle. The multilamellar liposomes are generally surrounded by mainly two phospholipid bilayers.
The vesicle becomes fuse with the cell membrane in addition to the organelles present in the cell to release their contents. Many various types of vesicles are present in the cell. A vesicle is involved in breakdown, temporary storage of food substances and enzymes, buoyancy control, and transport molecules to different parts of the cell, and they also serve as a chemical reaction chamber.
Types of Vesicle and Their Function
- Vacuoles: A large vacuole present in the center of the plant cell is a characteristic feature. It mostly consists of water which controls the osmotic balance of the plant cell and mainly assists as storage of many nutrients.
- Lysosomes: It is a vital type of vesicle which is involved in the digestion. Many food vacuoles become fuse with lysosomes, which consists of enzymes to digest the food particles.
- Transport Vesicles: They contribute to the molecular ways present between the locations inside the cell. For example, they transport proteins from RER to the Golgi apparatus.
What is Vacuole?
A type of vesicle that mostly consists of water and a characteristic feature of a plant cell as well as in animal cells, bacterial cells, fungal cells, and in some protists is known as the vacuole. Vacuole consists of many organic compounds other than water, such as enzymes and inorganic compounds.
Due to the fusion of many multiple vesicles, the vacuole formed. The shape and the size of vacuole fluctuate reliant on the requirement of the cell. The function of the vacuole also varies according to the type of the cell, which consists of the vacuole.
Functions of Vacuole
Many major functions of the vacuole are Storing water in plants, Isolating harmful materials to the cells, Regulating internal turgor pressure, Regulating internal pH, Storing small molecules, Storing waste products temporary and exporting them when needed, Supporting structural rigidity in plant cells, Storing proteins which are required by germination, and Increasing the size quickly by just using water.
Types of Vacuole
Different types of vacuole are Bacterial Vacuoles, Plant Vacuoles, Fungi Vacuoles, and Animal Vacuoles.