Difference Between Prozac and Zoloft


Main Difference

These both the antidepressants drugs belong to the group of drugs called selective serotonin reuptake inhibitors (SSRIs). They are known as the top drugs when it comes to deal with anxiety, depression or obsessive-compulsive symptoms. Despite the similar function, they both have different active ingredients, as Prozac holds Fluoxetine, whereas Zoloft contains Sertraline as the active ingredient in it.

What is Prozac?

The medicine comes in the capsule and even in the liquid form, while using it in the capsule form; one should never broke or chew the tablet as at the specific time that would cause a lot of drug to release. Furthermore, it is mentioned that both Prozac and Zoloft should be taken exactly as prescribed by the doctor and even its usage after a bit time difference can land you in some serious effects. The other functions rather than anxiety and depression problem it can also be used to treat the premature ejaculation, although, it totally depends upon the doctors prescription.


What is Zoloft?

The Sertraline hydro-chloride antidepressants are being produced by the globally acknowledged pharmaceutical Pfizer. Zoloft, under the brand name of Pfizer comes as a coated tablet or as concentrated solution, which is to be mixed with water to make it diluted.

Key Differences

  1. As both these drugs should be taken in adequate amount as prescribed by the doctor, although, Zoloft can be a step ahead from Prozac as it can cause severe diarrhea.
  2. The molecular weight of Prozac is 345.79, whereas molecular weight of Zoloft is 342.7.
  3. Prozac comes in tablet or ready-for-use liquid, whereas Zoloft comes in a coated tablet form and concentrated solution which is to be used after mixing it with water.

Comparison Video

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Janet White

Janet White is a writer and blogger for Difference Wiki since 2015. She has a master's degree in science and medical journalism from Boston University. Apart from work, she enjoys exercising, reading, and spending time with her friends and family. Connect with her on Twitter @Janet__White