Haemostasis vs. Thrombosis
Haemostasis and Thrombosis Definitions
Haemostasis vs. Thrombosis
Haemostatsis is considered as the natural process of clotting inside the body, which occurs mainly to stop the excessive flow of blood from a ruptured blood vessel wall that takes place due to an injury. On the other hand, thrombosis is considered as an overestimated means which many time results in severe complications, for example, the immobilization of blood due to the obstruction occurs inside the blood vessel and ultimately cause death in many severe conditions.
The main reason behind the occurrence of haemostasis is that it consists of the activation of coagulation mechanism to prevent the blood flow from an injury in the vessel walls; on the flip side, the primary reason for the happening of thrombosis is that it includes a process which is known as Virchow’s triad that generally explains the factors that take place and contribute in the production of a clot in an excessive behavior consisting of stasis, hypercoagulability, and as well as injury to endothelium.
The different types of haemostasis are described to control the bleeding is through mechanical agents, chemical agents, and physical agents based on the situation. In contrast, the thrombus contains two types, such as Arterial thrombus and Venous Thrombus.
The process of haemostasis is achieved when there is a rupture of the vessel includes vascular constriction, platelet plug formation, blood clot formation, and fibrous tissue growth or dissolution; while thrombosis occurs when there is an injury to the blood vessel, altered blood flow, and abnormal coagulability of the blood.
What is Haemostasis?
The natural biological process which occurs to prevent the body from going through a loss of a large amount of blood resulting due to vascular injury is known as the haemostasis. The basic process of haemostasis usually centered on the complicated sequences of steps that contain the other blood cells, such as tissue factor (TF), the particular blood proteins known as coagulation factors, and the action of platelets.
Right after the injury in blood vessels occurs following pain, the activated biological haemostasis comes into action and starts forming a series of steps. In the first step, the vasoconstriction occurs to lower the flow of blood into the affected area. After that, the platelets which are flowing will hurry to the affected area and get attached to the endothelium wall, and combined in clusters.
The activation of platelets will further start the following series of enzymatic reactions, which further result in coagulation. Moreover, at the termination of these steps of actions, a protein is formed, which is called fibrin, produce an established hemostatic wadding, which then stops further bleeding.
What is Thrombosis?
A process that comprises the formation of a thrombus or a blood clot inside the vessel is called thrombosis. The primary mechanism of thrombosis is quite like the process of haemostasis. The complications or intensity of thrombosis is relatively higher and occurs because of fundamental health situations.
The clot formed from abnormal conditions block the normal flow of blood and ultimately leads to severe health conditions if the clot moves inside the blood vessel, which supplies blood to the vital organs in the body, for example, to the brains and lungs.
There are two types of thrombosis; Venous thrombosis and Arterial thrombosis. The venous thrombosis contains renal vein thrombosis, deep vein thrombosis, cerebral venous thrombosis, and portal vein thrombosis, etc. The arterial thrombosis generally happens because of a rupture of atheroma in arteries or because of a stasis which initiated by atrial fibrillation in the heart.
The pathophysiology of thrombosis or thrombus formation is explained by a triangle, which is Virchow’s triad. It gives factors that include injury to the blood vessel, the abnormal flow of blood in the vessels, and the hypercoagulability of blood.