Difference Wiki

Agglutination vs. Coagulation

The main difference between Agglutination and Coagulation is that Agglutination is commonly referred to accumulation of small particles together and this process can be carried out by many particles, whereas Coagulation is referred to the formation of clumps in the solution after reaction of the particles due to multiple plasma factors that take place in blood.

Key Differences

Agglutination can be carried out by as many particles, but coagulation is the property of blood for the formation of clots, or it can also take place in colloidal suspensions.
Samantha Walker
Jun 17, 2020
Agglutination is carried out by the reaction of antigens and antibodies in the blood; conversely, the coagulation observed in the blood due to the enabling of multiple plasma factors.
Agglutination is the accumulation of small particles in a solution; on the other hand, coagulation is the formation of clumps in the solution.
Agglutination has its uses in the identification of blood groups for an individual and identification of the virus in the subject; but, coagulation seen in the clotting of wounds after injuries in humans and other living organisms.
Agglutination usually results in solid masses when the components in the solution react with each other, on the flip side, coagulation results in the formation of clumps after the multi plasma reaction.

Comparison Chart

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Agglutination is the accumulation of small particles together to form a solid mass.
Coagulation is the formation of clumps in the solution after the reaction of the particles.
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End Resultants

A solid mass of small particles
Formation of clumps

Reactants

Mainly occurs between antigens and antibodies
Observed in the blood due to multiple plasma factors

Occurrence

It can occur between any particle
It occurs in blood as the formation of a clot or as colloidal suspensions
Harlon Moss
Jun 17, 2020

Application

Use in the identification of blood groups and viral infections
Blood clotting

Agglutination and Coagulation Definitions

Agglutination

The act or process of agglutinating; adhesion of distinct parts.

Coagulation

To cause transformation of (a liquid or sol, for example) into or as if into a soft, semisolid, or solid mass.
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Agglutination

A clumped mass of material formed by agglutination. Also called agglutinate.

Coagulation

To become coagulated
As it cooled, the sauce began to coagulate.

Agglutination

(Biology) The clumping together of cells or particles, especially bacteria or red blood cells, usually in the presence of a specific antibody or other substance.

Coagulation

The precipitation of suspended particles as they increase in size (by any of several physical or chemical processes)(e.g. of proteins)

Agglutination

(Linguistics) The formation of words from morphemes that retain their original forms and meanings with little change during the combination process.

Coagulation

The process by which blood forms solid clots.
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Agglutination

The act of uniting by glue or other tenacious substance; the state of being thus united; adhesion of parts.

Coagulation

Similar solidification of other materials (e.g. of tofu).

Agglutination

(linguistics) Combination in which root words are united with little or no change of form or loss of meaning. See agglutinative.

Coagulation

The change from a liquid to a thickened, curdlike, insoluble state, not by evaporation, but by some kind of chemical reaction; as, the spontaneous coagulation of freshly drawn blood; the coagulation of milk by rennet, or acid, and the coagulation of egg albumin by heat. Coagulation is generally the change of an albuminous body into an insoluble modification.

Agglutination

The clumping together of red blood cells or bacteria, usually in response to a particular antibody.

Coagulation

The substance or body formed by coagulation.

Agglutination

The act of uniting by glue or other tenacious substance; the state of being thus united; adhesion of parts.

Coagulation

The process of forming semisolid lumps in a liquid

Agglutination

Combination in which root words are united with little or no change of form or loss of meaning. See Agglutinative, 2.

Agglutination

A clumping of bacteria or red cells when held together by antibodies (agglutinins)

Agglutination

The building of words from component morphemes that retain their form and meaning in the process of combining

Agglutination

The coalescing of small particles that are suspended in solution; these larger masses are then (usually) precipitated

Agglutination vs. Coagulation

Agglutination is referred to as the accumulation of small particles in a solution together due to a reaction that takes place between these inner particles to form solid masses of small particles. In contrast, coagulation referred to the formation of clumps in the solution. In Agglutination, the resultants after the reaction of the components in the solution are solid masses, whereas, in the case of coagulation, the resultants are the small particles that accumulated in the form of clumps.

Agglutination is carried out by the reaction of antigens and antibodies commonly in blood, but it can also carry out by taking the antigens and antibodies as it is an antigen-antibody reaction, but coagulation observed in the blood due to the enabling of multiple plasma factors.

Agglutination can be carried out by many particles, but coagulation is the property of clot formation in the blood or colloidal suspensions. Agglutination carried out for their use in the identification of blood groups for an individual as well as identification of the virus in the subject; however, coagulation as being the clotting of blood have their uses in the clotting of wounds after injuries in humans and other living organisms.

What is Agglutination?

Agglutination is the accumulation of small particles in a solution together due to a reaction that takes place between these inner particles to form solid masses of these accumulated smaller particles. Another definition for agglutination is that it is a process of clumping of particles in a solution.

The mass of accumulated particles stays suspended or sinks to the bottom of the solution. This end product in terms of agglutination is also known as aggregate. This phenomenon observed between the particles that are already present in that solution.

In terms of biology, the formulation of aggregates of antigen and antibody complexes are one of the best examples for understanding the procedure of agglutination. This process here also helps in cross-matching blood groups as their practical use in daily routine hospitalized cases. If, by mistake, the wrong blood group given to a patient, the reaction between antigens and antibodies can lead to the formation of a clot of red blood cells and eventually leading to the death of that patient in severe conditions.

Haemagglutination is the method of accumulation of red blood cells. This is the type of agglutination where red blood cells form aggregates. It is also used for quantification of virus proportions.

Agglutination can be carried out by many particles and are not specific to only a particular type of plasma matter in the blood. Like above, agglutination has various applications in the biological field. Leukoagglutination, like haemagglutination, is the clumping of white blood cells.

The detection of pathogenic cells and their toxins is also carried out by agglutination. Antibody molecules can bind with multiple antigens, which makes it useful for application in these areas. Whenever these antigens bind with antibodies, they form antigen and antibody agglutination.

And as the toxins that are produced by pathogens antigens, thus for detection of these antigens, a suitable antibody can be used, i.e., the suitable antibody will lead to agglutination, which will lead to the identification of that pathogen.

What is Coagulation?

Coagulation referred to as the formation of blood clotting or gelling of particles. This process of coagulation takes place is carried out in colloidal suspensions. Whenever there are unstable particles present in a solution, the process of coagulation can take place. Here a substance that can cause the coagulation is known as a coagulant.

The stability in this colloidal solution is dependent upon the electrical charge that is carried out by them. The imbalances in the charges of these charged particles here lead to coagulation. When the particles accumulate due to imbalances charges, they form aggregates. These aggregates settle in a container due to gravitational force, which termed as coagulation.

In the case of blood coagulation, i.e., blood clotting, the blood clots are initiated with platelet plug formation, which is followed by intrinsic or extrinsic pathways and, in the end, a common pathway. Whenever trauma faced by endothelial cells, a chemical released in the blood vessels, which activates and aggregates platelets, whenever this trauma faced by cells alone, the release of histamine takes place with another inflammatory mediator also comes in the way, which includes serotonin, major basic proteins, prostaglandin, prostacyclin, etc. With these chemicals, the platelet plug comes formed.

Reactive extracellular matrix material triggers two chain reactions that are known as intrinsic or extrinsic pathways, which at the end, activate factor X and thus leading to the third step of the common pathway. This common pathway forms fibrin mesh, which traps blood cells and forms blood clots. This process of coagulation is certainly disturbed by major diseases like Hemophilia, which is a condition in which the body’s ability to form blood clots hindered due to the lack of the process of coagulation.

Thus leading to excessive bleeding, and thus, this blood loss also leads to myocardial infarction or strokes like devastating conditions. As seen here above in the case of Coagulation, the resultants are the small particles that accumulated, and their ultimate produce is in the form of clumps.

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