Difference Between Cytoplasm and Nucleoplasm

Main Difference

The main difference between cytoplasm and nucleoplasm is that the cytoplasm is the part of the protoplasm of a cell that is present outside the nucleus within the cell, whereas the nucleoplasm is the part of protoplasm of a cell that is present inside the nucleus within the cell.

Cytoplasm vs. Protoplasm

The cytoplasm is the gelatinous mass of the cell that is present outside the nucleus, whereas the nucleoplasm is the highly gelatinous mass of the cell that is present inside the nucleus. The cytoplasm is covered by the plasma membrane, while the nucleoplasm is covered by the nuclear membrane. The cytoplasm contains all the important enzymes and minerals that are important for carrying out some important reactions of the cell; on the other hand, nucleoplasm contains all the important enzymes that are important for the formations of DNA, RNA, and proteins.

The cytoplasm is usually known for its gelatinous ability on the flip side, nucleoplasm mainly known for its highly gelatinous ability. The cytoplasm is present in all the living organisms’ cells, including micro-organisms’ cells, whereas the nucleoplasm is not present in all living organisms’ cells — cytoplasm involved in cell division, whereas the nucleoplasm involved in nuclear division. The cytoplasm is the part of the cell that contains all the organelles of the cell, while the nucleoplasm is the part of the cell that contains nuclear content and nucleolus within the nucleus.

The cytoplasm is the fluid content that is under the motion of organelles, which is called cyclosis, whereas the nucleoplasm has no such motion. The cytoplasm contains two portions of sol and gel, whereas the nucleoplasm does not contain such portions. Cytoplasm does not have any sites of nucleotides formation, whereas the nucleoplasm has such sites of nucleotides and nucleosides formation.

Comparison Chart

CytoplasmNucleoplasm
The cytoplasm is the part of the protoplasm of a cell that is present outside the nucleus within the cell.Nucleoplasm is the part of the protoplasm of a cell that is present inside the nucleus within the cell.
Location
Outside the nucleusInside the nucleus
Structure
Less gelatinous structureHighly gelatinous structure
Membrane
The outer membrane is a plasma membraneThe outer membrane is a nuclear membrane
Contents
It contains enzymes, proteins, salts, and minerals.It contains enzymes, organic acids, salts, etc
Occurrence
In all known cellsOnly in eukaryotic cells
Division
Involves in cell divisionInvolves in nuclear division
Immerse
Cell organellesNucleolus
Cyclosis
Organelles undergo motionNo motion in it
Sites
For the formation of proteins and ATPFor the formation of DNA and RNA

What is Cytoplasm?

The cytoplasm is the part of the protoplasm of the cell that is present within the cell but outside the nucleus. It is the site where all the important organelles of the cell are present, including the nucleus. The cytoplasm is covered by the plasma membrane or cell membrane. In the cytoplasm, all the organelles are undergoing the motion that refers to the cyclosis or streaming movement or dead slow movement of cell organelles.

The cytoplasm is a gelatinous structure but less than the nucleoplasm. The cytoplasm contains all the important contents of the cell, such as proteins, amino acids, minerals, enzymes, and salts. The enzymes that are present in the cytoplasm are very necessary for carrying all the important functions of the cells, such as glycolysis, ATP formation, and synthesis of proteins and amino acids.

The cytoplasm is the portion of the cell that undergoes the cell division, the division of the whole cell in which the cell is divided into two daughter cells. The cytoplasm contains all the important organelles of the cell that are involved in different functions of the cells, such as mitochondria, endoplasmic reticulum, chloroplasts, Golgi apparatus, etc. The cytoplasm is present in all the cells that are known today, such as prokaryotes and eukaryotes.

Physical Nature

  • Sol-Like: Less dense structure that is present near to the nucleus called endoplasm.
  • Gel-Like: More dense structure that is present near to the plasma membrane called ectoplasm.

What is Nucleoplasm?

Nucleoplasm is the part of the protoplasm of the cell that is present inside the nucleus within the cell. Nucleoplasm is the site of the cell that also contains all the important organelles that are nucleolus, etc. It involves the formation of ribosomes and also known as the factory of ribosomes. Nucleoplasm always covered by the nuclear membrane.

In the nucleoplasm, no organelles and nuclear content are under the motion refer to the cyclosis or streaming movement or dead slow movement of organelles. Nucleoplasm is a more gelatinous structure than the cytoplasm. Nucleoplasm contains nuclear contents such as DNA, RNA, proteins, enzymes, salts, organic acids. It contains enzymes that are very necessary for the synthesis of DNA and RNA.

It also contains enzymes that are involved in cell division and nuclear division and chromatin formation, etc. Nucleoplasm is involved in the nuclear division that is also known as karyokinesis. It divides the nucleus into two daughter nuclei. Nucleoplasm is present in few cells, such as in eukaryotic cells and the cells that contain a nucleus. Nucleoplasm also contains some nuclear pores that may or may not continue with the cytoplasm.

Portions

  • Central Region: Present inside the nucleus contain rDNA and rRNA.
  • Peripheral Region: Present at the outer side contains RNA.

Key Differences

  1. The cytoplasm is present at the outer side of the nucleus, whereas the protoplasm is present at the inner side of the nucleus.
  2. The cytoplasm is covered by the cell membrane, while protoplasm is covered by the membrane of the nucleus.
  3. The cytoplasm contains organelles of the cell; on the other hand, the nucleoplasm contains the only nucleolus.
  4. The cytoplasm can perform the cell motion by the cellular organelles; on the flip side, the nucleoplasm contains a nucleolus that cannot perform the cell motion.
  5. The cytoplasm is present in all the cells of the earth, whereas the nucleoplasm is present only in cells of some organisms.
  6. The cytoplasm can perform the cytokinesis, whereas the nucleoplasm can perform the karyokinesis.

Conclusion

The above discussion concludes that the cytoplasm is the part of protoplasm that does not contain chromatin material, whereas the nucleoplasm is the part of protoplasm that contains chromatin material.

Janet White

Janet White is a writer and blogger for Difference Wiki since 2015. She has a master's degree in science and medical journalism from Boston University. Apart from work, she enjoys exercising, reading, and spending time with her friends and family. Connect with her on Twitter @Janet__White

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