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Turner Syndrome vs. Klinefelter Syndrome: What's the Difference?

Edited by Aimie Carlson || By Harlon Moss || Updated on October 28, 2023
Turner syndrome is a chromosomal condition in females; Klinefelter syndrome is a chromosomal condition in males.

Key Differences

Turner syndrome is a genetic disorder affecting females, resulting from a missing or partially missing X chromosome. On the other hand, Klinefelter syndrome is a condition in males, caused by the presence of an extra X chromosome.
Individuals with Turner syndrome typically have a single X chromosome, symbolized as "45,X" or "45,X0". In contrast, individuals with Klinefelter syndrome have two X chromosomes and one Y chromosome, represented as "47,XXY".
Turner syndrome can lead to short stature, ovarian dysfunction, and heart defects. Meanwhile, Klinefelter syndrome can result in reduced testosterone, small testicles, and decreased body and facial hair.
While Turner syndrome is exclusively found in females and affects their development, Klinefelter syndrome affects males, influencing their physical and cognitive growth.
Both Turner syndrome and Klinefelter syndrome are non-heritable genetic conditions. Early diagnosis and intervention can help manage their symptoms and potential complications.

Comparison Chart

Chromosomal Pattern

45,X or 45,X0

Gender Affected


Primary Symptoms

Short stature, ovarian dysfunction
Reduced testosterone, small testicles

Secondary Symptoms

Heart defects
Decreased body and facial hair

Treatment Focus

Growth hormone, estrogen therapy
Testosterone therapy

Turner Syndrome and Klinefelter Syndrome Definitions

Turner Syndrome

A genetic anomaly leading to short stature in females.
The doctor attributed Lisa's short stature to Turner syndrome.

Klinefelter Syndrome

A chromosomal variation leading to reduced male physical traits.
Klinefelter syndrome was the reason behind Mike's decreased facial hair.

Turner Syndrome

A disorder characterized by a female's single X chromosome.
Medical professionals advised a specialized growth plan for Sarah because of her Turner syndrome.

Klinefelter Syndrome

A genetic anomaly affecting male reproductive and physical development.
Due to Klinefelter syndrome, Brian has small testicles.

Turner Syndrome

A genetic condition in females due to a missing X chromosome.
Jane was diagnosed with Turner syndrome at birth.

Klinefelter Syndrome

A genetic condition in males with an extra X chromosome.
John was diagnosed with Klinefelter syndrome during puberty.

Turner Syndrome

A chromosomal irregularity affecting female development.
Due to Turner syndrome, Emily requires regular heart check-ups.

Klinefelter Syndrome

A disorder causing males to have 47 chromosomes instead of 46.
Due to Klinefelter syndrome, Tom takes testosterone therapy.

Turner Syndrome

A syndrome resulting from an incomplete or absent second X chromosome in females.
Turner syndrome was the diagnosis after the chromosomal analysis.

Klinefelter Syndrome

A syndrome resulting from an XXY chromosome pattern in males.
A chromosomal test confirmed Paul's diagnosis of Klinefelter syndrome.


How is Turner syndrome diagnosed?

Through karyotyping, where the number and structure of chromosomes are analyzed.

What is Klinefelter syndrome?

Klinefelter syndrome is a condition in males caused by an extra X chromosome.

Are Turner syndrome and Klinefelter syndrome related?

Both are chromosomal disorders, but they affect different genders and have different causes.

What is Turner syndrome?

Turner syndrome is a genetic disorder in females due to a missing or incomplete X chromosome.

Can Turner syndrome affect males?

No, it only affects females.

Are these conditions hereditary?

Both conditions are genetic but typically not inherited.

Are there treatments for Klinefelter syndrome?

Yes, including testosterone therapy and fertility treatments.

Is Klinefelter syndrome a severe condition?

It has physical and cognitive implications, but with treatment, many lead normal lives.

Can females have Klinefelter syndrome?

No, it's a male-specific condition.

Can individuals with Turner syndrome have children?

Most have ovarian dysfunction and need fertility treatments to conceive.

Is Turner syndrome life-threatening?

It can have associated health issues, but with proper management, most lead normal lives.

Can Turner syndrome be prevented?

No, it's a random genetic anomaly.

Can Klinefelter syndrome be prevented?

No, it occurs randomly during conception.

What are the main symptoms of Turner syndrome?

Short stature, ovarian dysfunction, and certain physical features.

Can males with Klinefelter syndrome reproduce?

Many face challenges with fertility but treatments can assist some in fathering children.

Are there treatments for Turner syndrome?

Yes, including growth hormones and estrogen therapy.

How is Klinefelter syndrome identified?

Through a chromosomal analysis or karyotype test.

How prevalent is Klinefelter syndrome?

It affects roughly 1 in 500 to 1,000 newborn males.

What are the main symptoms of Klinefelter syndrome?

Reduced testosterone, small testicles, and decreased body/facial hair.

How common is Turner syndrome?

It affects about 1 in 2,500 newborn girls.
About Author
Written by
Harlon Moss
Harlon is a seasoned quality moderator and accomplished content writer for Difference Wiki. An alumnus of the prestigious University of California, he earned his degree in Computer Science. Leveraging his academic background, Harlon brings a meticulous and informed perspective to his work, ensuring content accuracy and excellence.
Edited by
Aimie Carlson
Aimie Carlson, holding a master's degree in English literature, is a fervent English language enthusiast. She lends her writing talents to Difference Wiki, a prominent website that specializes in comparisons, offering readers insightful analyses that both captivate and inform.

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