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Diclofenac Sodium vs. Diclofenac Potassium: What's the Difference?

Edited by Janet White || By Harlon Moss || Updated on October 15, 2023
Diclofenac sodium and diclofenac potassium are salt forms of the same pain-relief medication. Sodium is widely used due to its solubility, while potassium may be gentler on the stomach.

Key Differences

Diclofenac sodium and diclofenac potassium are two salt forms of the same medication, diclofenac, used to treat pain and inflammation. Sodium is more commonly used due to its better solubility, while potassium may be gentler on the stomach.
Diclofenac sodium is a salt form of diclofenac widely used in medications for pain and inflammation. Diclofenac potassium is another salt form of the same drug with potential benefits for gastrointestinal tolerance.
Diclofenac sodium, a common form of diclofenac, is favored for its solubility in water and faster absorption. Diclofenac potassium, another salt form, may be preferred when stomach irritation is a concern.
Diclofenac sodium and diclofenac potassium both refer to different salt forms of diclofenac, a nonsteroidal anti-inflammatory drug (NSAID). Sodium is commonly used, while potassium may be gentler on the stomach.
Diclofenac sodium and diclofenac potassium are salt forms of diclofenac, an NSAID used to alleviate pain and inflammation. Sodium is more widely used, while potassium may offer potential advantages for digestive comfort.

Comparison Chart


High in water, rapid absorption
Slightly lower solubility, potential gentler on the stomach


Quick and efficient
May have a similar bioavailability

Gastrointestinal Tolerance

May cause more irritation
Potentially gentler on the stomach

Dosage Form

Often in immediate-release tablets
Available as extended-release tablets

Common Usage

Widespread in NSAID medications
Used in specific formulations

Diclofenac Sodium and Diclofenac Potassium Definitions

Diclofenac Sodium

Diclofenac sodium is a salt form of diclofenac, an NSAID used for pain relief.
My doctor prescribed diclofenac sodium for my joint pain.

Diclofenac Potassium

Diclofenac potassium is preferred for those with stomach sensitivity to NSAIDs.
I switched to diclofenac potassium due to stomach discomfort.

Diclofenac Sodium

Diclofenac sodium is a non-prescription pain reliever for conditions like back pain.
I found relief with diclofenac sodium for my backache.

Diclofenac Potassium

Diclofenac potassium is used in extended-release tablets for prolonged pain relief.
The extended-release diclofenac potassium tablet helped with my chronic pain.

Diclofenac Sodium

Diclofenac sodium is an effective NSAID often used for post-surgery pain management.
The doctor recommended diclofenac sodium after my surgery.

Diclofenac Potassium

Diclofenac potassium, with its delayed release, provides continuous pain management.
Diclofenac potassium keeps my pain under control throughout the day.

Diclofenac Sodium

Diclofenac sodium is widely used to treat arthritis and other inflammatory conditions.
Diclofenac sodium improved my mobility and reduced pain.

Diclofenac Potassium

Diclofenac potassium, an NSAID salt, may be easier on the stomach.
Diclofenac potassium is gentler on my digestive system.

Diclofenac Sodium

Diclofenac sodium, a common pain medication, is known for its anti-inflammatory properties.
Diclofenac sodium helped reduce my swelling after the injury.

Diclofenac Potassium

Diclofenac potassium, another form of diclofenac, is used in specific formulations for patient comfort.
My doctor prescribed diclofenac potassium to reduce stomach irritation.


Which is more commonly used, diclofenac sodium or diclofenac potassium?

Diclofenac sodium is more widespread in NSAID medications.

What is diclofenac sodium used for?

Diclofenac sodium is used to relieve pain and inflammation in conditions like arthritis.

Is diclofenac sodium available without a prescription?

In some regions, diclofenac sodium is available over the counter for certain conditions.

Are there potential side effects of diclofenac sodium?

Yes, common side effects include stomach upset and gastrointestinal issues.

Is diclofenac sodium effective for acute pain?

Yes, it's often used for conditions like sports injuries and sprains.

What's the difference between diclofenac sodium and diclofenac potassium?

Sodium is more soluble, while potassium is gentler on the stomach.

How does diclofenac potassium differ in terms of dosage form?

It's often found in extended-release tablets for longer pain relief.

Do diclofenac sodium and diclofenac potassium have the same bioavailability?

Diclofenac potassium may have a similar bioavailability to diclofenac sodium.

Is diclofenac potassium more suitable for prolonged pain management?

Yes, it's often used in extended-release formulations for this purpose.

Can diclofenac sodium be used for post-surgery pain?

Yes, it's commonly used for post-operative pain management.

Are there any specific precautions when taking diclofenac potassium?

It's important to follow the doctor's instructions, especially if you have stomach issues.

Can diclofenac potassium be a better option for those with stomach sensitivity?

Yes, it's potentially gentler on the stomach compared to diclofenac sodium.

Are there known drug interactions with diclofenac sodium?

Yes, it can interact with certain medications, so consult your healthcare provider.

What's the primary mechanism of action for both diclofenac sodium and diclofenac potassium?

They inhibit inflammatory processes by reducing prostaglandin production.

Can diclofenac potassium be taken with food?

It can be taken with or without food, depending on your preference and tolerance.

Do both diclofenac sodium and diclofenac potassium belong to the same drug class?

Yes, they are both NSAIDs.

What is the recommended dosage for diclofenac sodium?

Dosage varies depending on the condition and the form of the medication.

Is diclofenac potassium available in immediate-release tablets?

No, it is typically found in extended-release forms.

Are there any age restrictions for diclofenac sodium and diclofenac potassium use?

Dosage adjustments may be needed for elderly patients.

Is diclofenac potassium available as a topical cream?

Diclofenac potassium is primarily available in oral tablet forms.
About Author
Written by
Harlon Moss
Harlon is a seasoned quality moderator and accomplished content writer for Difference Wiki. An alumnus of the prestigious University of California, he earned his degree in Computer Science. Leveraging his academic background, Harlon brings a meticulous and informed perspective to his work, ensuring content accuracy and excellence.
Edited by
Janet White
Janet White has been an esteemed writer and blogger for Difference Wiki. Holding a Master's degree in Science and Medical Journalism from the prestigious Boston University, she has consistently demonstrated her expertise and passion for her field. When she's not immersed in her work, Janet relishes her time exercising, delving into a good book, and cherishing moments with friends and family.

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