Astepro vs. Flonase

Main Difference

The main difference between Astepro and Flonase is that Astepro has Azelastine as active therapeutic agent and Flonase has Fluticasone as an active therapeutic agent.

Astepro vs. Flonase — Is There a Difference?

Difference Between Astepro and Flonase

Astepro vs. Flonase

Astepro is nasal spray containing Azelastine as an active therapeutic agent; on the other hand, Flonase is a nasal spray containing Fluticasone as an active therapeutic agent.

Astepro vs. Flonase

Astepro belongs to antihistamines while Flonase belongs to corticosteroids.

Astepro vs. Flonase

Astepro blocks the actions of histamine; on the other hand, Flonase inhibits the inflammation.

Astepro vs. Flonase

Astepro does not cause fungal infections, on the other hand, Flonase causes fungal infections.

Astepro vs. Flonase

Astepro use in children does not affect their growth rate, on the other hand, Flonase usage in children affects their growth rate and slows down it.

Astepro vs. Flonase

Astepro has a half-life of 22hrs, on the other hand, Flonase has a half-life of 7.8 hrs.


Astepro vs. Flonase

Astepro does not affect the body’s defense cells, on the other hand, Flonase decreases the cell count of the body’s defense cells so decreases the immunity of the patient.

Comparison Chart

Astepro is a nasal spray containing Azelastine.Flonase is a nasal spray containing Fluticasone.
Drug Category
Mechanism of Action
Inhibits the effects of histamine, which causes runny rose, sneezing, itchy, and watery eyes.Inhibits the inflammation which is due to allergic reactions.
Route of Administration
Salt Name
Azelastine hydrochlorideFluticasone propionate
22 hrs7.8 hrs
Side Effects
Bitter of mouth, drowsiness, Sneezing fits, Cough, nose bleeds, a burning feeling inside the nose, Dry mouth, Headache, Muscle aches, Red eyes OR weight gainHeadache, Burning in nose, Irritation in the nose, Bleeding, Cough
Therapeutic Uses
Allergic rhinitis, Nasal congestion reliever, Treats an itchy and watery eyesRelieves nasal congestion, Stops a drippy nose, Treats sneezing, Treats an itchy and watery eyes

What is Astepro?

Astepro is the brand name of Azelastine, which is used in the nasal sprays for the treatment of the hay fever( allergic rhinitis). Astepro nasal sprays contain the salt Azelastine hydrochloride. Astepro is an H1 receptor antagonist, and it is 0.1% and 0.15% nasal spray. Astepro 0.1% contains 0.1 % azelastine hydrochloride in isotonic aqueous solution which contains some other ingredients like sorbitol, benzalkonium chloride, hypromellose, sodium citrate, sucralose edetate disodium, benzalkonium chloride and purified water (pH 6.4). Astepro is formulated as a metered-spray solution. Each metered-dose of Astepro delivers the 137 mcg of azelastine hydrochloride which is equivalent to 125 mcg of azelastine base. Astepro has total 30ml of the nasal solution, which contains 200 metered sprays. Astepro 0.15% contains 0.1 5% azelastine hydrochloride in aqueous isotonic solution and contains other pharmaceutical ingredients which are sucralose hypromellose, edetate disodium, sodium citrate, benzalkonium chloride, sorbitol, and purified water. Astepro works well when allergens are less and if allergen count is more and exposure to allergens is prolonged, then it becomes less effective. Astepro also becomes less effective when nasal congestion is most prominent.

What is Flonase?

Flonase is a nasal spray. Flonase contains Fluticasone propionate which belongs to corticosteroid. Flonase inhibits or blocks the release of inflammatory substances in the body. Flonase is used for the cure of nasal congestion along with treating the seasonal allergic rhinitis that is due to deposition of allergens on the nasal mucosa and leads to the immediate hypersensitivity reaction. Flonase also eradicates the symptoms of watery eyes due to year-round or seasonal allergies. Flonase is prescribed to adults and child patients who are four years old or above. Flonase is over the counter drug. Those patients who are suffering from liver disease, glaucoma, cataracts, diabetes tuberculosis, herpes simplex virus of eyes or allergy or injury of nose should tell the doctor about their ailments if the doctor has prescribed them the Flonase. Flonase takes several days before it eradicates the symptoms. Patients should inform the doctor if the symptoms do not relieve after one week of the use of Flonase. Flonase lowers the white blood cells which are responsible for fighting the infections of the body so patients who are on treatment of Flonase should avoid visiting those people who are ill because of any infection. Flonase is never prescribed to children who are younger than four years without medical advice because it affects the growth in children. Some common side effects of Flonase are a headache, burning in the nose, irritation in the nose, bleeding, cough, nausea, and vomiting.


The conclusion of the above discussion is that both Astepro and Flonase are nasal sprays and are used to treat allergic rhinitis and belong to different pharmacological classes.