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Astepro vs. Flonase: What's the Difference?

Edited by Aimie Carlson || By Harlon Moss || Updated on October 5, 2023
Astepro and Flonase are nasal sprays for allergy relief; Astepro (azelastine) is antihistamine-based, while Flonase (fluticasone) is a corticosteroid.

Key Differences

Astepro, an antihistamine nasal spray, and Flonase, a corticosteroid nasal spray, hold key roles in managing nasal allergies. Astepro, with the active ingredient azelastine hydrochloride, predominantly works by blocking the action of histamines, which are substances involved in allergic reactions. On the other side, Flonase, characterized by fluticasone propionate as its active ingredient, acts by reducing the inflammation in the nasal passages, thereby managing the symptoms.
While both Astepro and Flonase share a common ground of mitigating nasal allergy symptoms, their mechanistic approach towards achieving relief significantly diverges. Astepro directly inhibits histamines, thus preventing typical allergy symptoms like sneezing, itchiness, and a runny nose. In contrast, Flonase doesn’t directly act on histamines but reduces the overall inflammation, addressing not only allergy symptoms but also other issues like nasal polyps.
Astepro usually boasts a rapid onset of action, providing relief quite promptly after administration. Patients using Astepro might experience a notable difference in their nasal allergy symptoms within an hour of usage. Flonase, while quite effective, may necessitate consistent use over several days to weeks before the full benefits are observable, making it possibly less suitable for sporadic or sudden onset symptoms.
A major consideration when selecting between Astepro and Flonase could pivot on the user’s specific requirements and the nature of their allergies. Astepro might be deemed more suitable for individuals who require quick relief from sudden, intense allergy symptoms. Flonase could be the preferred option for those who deal with persistent allergies and can adhere to a consistent administration schedule.
Patient preference, after considering possible side effects, may also sway the choice between Astepro and Flonase. Astepro users might encounter a bitter taste post-administration, which may be a deciding factor for some. Flonase might cause side effects like nosebleeds or throat irritation, which might guide selection based on a user’s past experiences and comfort.

Comparison Chart



Use Speed

Often fast-acting
May require consistent use for full effect


As needed for rapid relief
Regular, even without immediate symptoms

Side Effects

Possible bitter taste
Potential for nosebleeds, throat irritation

Primary Function

Directly inhibits histamines
Reduces overall nasal inflammation

Astepro and Flonase Definitions


Astepro works by directly inhibiting histamines in the body.
The active ingredient in Astepro prevents histamines from causing itchy and runny noses.


Flonase is a nasal spray that contains the corticosteroid fluticasone.
He used Flonase daily to reduce his allergic rhinitis symptoms.


Astepro may cause a bitter taste following administration.
Though Astepro relieved his symptoms, he was bothered by the lingering bitter taste.


Flonase works by decreasing inflammation in the nasal passages.
Using Flonase consistently helped mitigate her chronic nasal congestion.


Astepro is an antihistamine nasal spray used for allergy relief.
My doctor recommended Astepro to help alleviate my seasonal allergy symptoms.


Flonase may require consistent usage over time to experience full benefits.
Although he didn’t notice immediate relief, Flonase significantly alleviated his allergies after a week of daily use.


Astepro may provide quick relief and can be used as needed.
When the pollen count surged, she found immediate relief using Astepro.


Flonase can be utilized for various nasal symptoms, beyond allergies.
Apart from pollen allergies, she used Flonase to manage her nasal polyps.


Astepro is effective in mitigating sneezing, nasal congestion, and other allergy symptoms.
Since using Astepro, her sneezing and nasal congestion drastically reduced during spring.


Flonase is available over the counter without a prescription.
She bought Flonase from the pharmacy to manage her seasonal allergies without visiting a doctor.


How does Flonase work to alleviate allergy symptoms?

Flonase reduces nasal inflammation, thereby relieving associated allergy symptoms.

Can Astepro provide immediate relief?

Astepro is known for its quick onset of action, often providing relief soon after administration.

Is Flonase available without a prescription?

Yes, Flonase is available over the counter without a prescription.

Can Flonase be used for children?

Yes, Flonase has formulations suitable for children, but always consult healthcare professionals first.

Should I shake the Flonase bottle before use?

Yes, it’s advisable to shake Flonase gently before each use to ensure consistency.

What is Astepro used for?

Astepro is used to manage and alleviate nasal allergy symptoms by inhibiting histamines.

How frequently should Astepro be used?

Usage frequency for Astepro can vary; follow prescribed guidelines or label instructions.

Can Flonase be used to treat sinus infections?

Flonase primarily addresses allergy symptoms, not the underlying causes of sinus infections.

Can Astepro treat eye allergy symptoms?

Astepro is primarily for nasal symptoms, but there’s a formulation, Astepro Ophthalmic, for eye allergies.

Can Flonase cause nosebleeds?

Yes, Flonase can cause nosebleeds as a potential side effect.

Can Astepro be used in conjunction with oral antihistamines?

Often yes, but always consult a healthcare professional before combining medications.

Is drowsiness a common side effect of Astepro?

Drowsiness can occur with Astepro, and caution should be exercised when driving or operating machinery.

Can Flonase affect sense of smell or taste?

There have been reports of altered sense of smell or taste with Flonase use.

How long does it take for Flonase to work?

Flonase may require several days to weeks of consistent use to experience maximal relief.

Is Astepro available in generic form?

Yes, generic versions of Astepro (azelastine hydrochloride) are available.

Can Flonase be used for non-allergic rhinitis?

Flonase can be effective in managing symptoms of both allergic and non-allergic rhinitis.

Can Astepro cause nasal dryness?

Yes, nasal dryness is a potential side effect of Astepro.

Are there common side effects associated with Astepro?

A notable side effect of Astepro can be a bitter taste after usage.

Is Astepro suitable for perennial allergies?

Yes, Astepro can be used to manage both seasonal and perennial allergies.

Should Flonase be used every day for it to be effective?

Consistent daily use of Flonase may be necessary to experience its full benefit.
About Author
Written by
Harlon Moss
Harlon is a seasoned quality moderator and accomplished content writer for Difference Wiki. An alumnus of the prestigious University of California, he earned his degree in Computer Science. Leveraging his academic background, Harlon brings a meticulous and informed perspective to his work, ensuring content accuracy and excellence.
Edited by
Aimie Carlson
Aimie Carlson, holding a master's degree in English literature, is a fervent English language enthusiast. She lends her writing talents to Difference Wiki, a prominent website that specializes in comparisons, offering readers insightful analyses that both captivate and inform.

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