Difference Wiki

Zyban vs. Wellbutrin: What's the Difference?

Edited by Aimie Carlson || By Harlon Moss || Updated on October 19, 2023
Zyban and Wellbutrin are brand names for bupropion, but Zyban is used primarily for smoking cessation, while Wellbutrin is prescribed for depression.

Key Differences

Zyban is a brand name for the drug bupropion, which has been specifically developed and approved for smoking cessation. Wellbutrin, while also being a brand name for bupropion, is oriented towards the treatment of depression.
Both Zyban and Wellbutrin are the same drug in essence, but their primary purposes differ based on their branding and FDA approvals.
A doctor might prescribe Zyban for someone looking to quit smoking, given its formulation and dosing tailored to this purpose. On the other hand, Wellbutrin would be the choice if the primary concern was depression.
It's crucial to understand that while both Zyban and Wellbutrin can be used interchangeably in some cases (under medical guidance), their primary applications are distinct. This differentiation in branding helps in guiding physicians and patients towards the right product for their specific needs.

Comparison Chart

Primary Use

Smoking cessation
Depression treatment

Active Ingredient


FDA Approval

Specifically for helping quit smoking
Specifically for treating depression

Branding Orientation

Focused on nicotine withdrawal and reducing cravings
Focused on mood elevation and managing depressive symptoms

Possible Off-label Use

Can be used for depression under medical guidance
Can be used for smoking cessation under medical guidance

Zyban and Wellbutrin Definitions


A brand name for bupropion used in smoking cessation.
He started taking Zyban to help him quit smoking.


An antidepressant medication.
She noticed a positive change in her mood after starting Wellbutrin.


An FDA-approved drug for quitting smoking.
The doctor recommended Zyban for his nicotine addiction.


Can aid in mood elevation and stabilization.
After a few weeks on Wellbutrin, he felt more emotionally stable.


Sometimes prescribed off-label for depression.
While Zyban is mainly for smokers, it was prescribed to her for mood elevation.


A brand name for bupropion intended for treating depression.
Wellbutrin helped him manage his depressive episodes.


Can aid in reducing the urge to smoke.
With the help of Zyban, she felt less urge to light up a cigarette.


An FDA-approved drug for depression.
Based on her symptoms, the psychiatrist prescribed Wellbutrin.


Medication to help reduce nicotine withdrawal symptoms.
After starting Zyban, her cravings for cigarettes reduced.


Sometimes used off-label for smoking cessation.
Although its main use is for depression, Wellbutrin helped him quit smoking.


Can Zyban be prescribed for depression?

While its primary use is for smoking cessation, Zyban can be prescribed off-label for depression.

What is the primary purpose of Wellbutrin?

Wellbutrin is primarily prescribed to treat depression.

How long does it take for Wellbutrin to affect mood?

It typically takes a few weeks for patients to notice mood improvements with Wellbutrin.

Are Zyban and Wellbutrin the same medication?

Yes, both are brand names for bupropion but have different primary uses.

Can Wellbutrin be used to quit smoking?

Yes, under medical guidance, Wellbutrin can be used for smoking cessation.

Who manufactures Zyban?

Zyban is manufactured by GlaxoSmithKline.

Are there side effects associated with Zyban?

Yes, like all medications, Zyban has potential side effects which should be discussed with a physician.

Can Wellbutrin help with anxiety?

Some people find relief from anxiety with Wellbutrin, but its primary use is for depression.

Is bupropion the active ingredient in both Zyban and Wellbutrin?

Yes, bupropion is the active ingredient in both.

How does Zyban help in quitting smoking?

Zyban helps reduce nicotine withdrawal symptoms and cravings.

How long is a typical treatment course with Wellbutrin for depression?

Treatment length varies, but many people take Wellbutrin for several months or longer.

How should Zyban be stored?

Zyban should be stored at room temperature, away from moisture and heat.

Is weight gain a side effect of Wellbutrin?

Unlike some other antidepressants, Wellbutrin is not typically associated with weight gain.

Is it safe to switch between Zyban and Wellbutrin?

Any changes or switches should be made under the guidance of a healthcare professional.

Are there any known drug interactions with Wellbutrin?

Yes, there are known drug interactions; it's crucial to inform your doctor of all medications you're taking.

What is Zyban used for?

Zyban is primarily used to help people quit smoking.

Are there generic versions available for these medications?

Yes, the generic name for both is bupropion.

Is it necessary to have a prescription for Wellbutrin?

Yes, Wellbutrin is available by prescription only.

Can Zyban be used in combination with nicotine patches?

Some people use both under medical guidance, but it's essential to discuss with a healthcare professional.

Can you drink alcohol while taking Zyban?

It's recommended to avoid alcohol when taking Zyban, as it can increase the risk of side effects.
About Author
Written by
Harlon Moss
Harlon is a seasoned quality moderator and accomplished content writer for Difference Wiki. An alumnus of the prestigious University of California, he earned his degree in Computer Science. Leveraging his academic background, Harlon brings a meticulous and informed perspective to his work, ensuring content accuracy and excellence.
Edited by
Aimie Carlson
Aimie Carlson, holding a master's degree in English literature, is a fervent English language enthusiast. She lends her writing talents to Difference Wiki, a prominent website that specializes in comparisons, offering readers insightful analyses that both captivate and inform.

Trending Comparisons

Popular Comparisons

New Comparisons