Tylenol vs. Percocet
Main DifferenceThe main difference between Tylenol and Percocet is that Tylenol is the brand name of analgesic and antipyretic acetaminophen and Percocet is the brand name of opioid analgesic oxycodone and non-opioid analgesic and antipyretic acetaminophen.

Difference Between Tylenol and Percocet
Tylenol vs. Percocet
Tylenol has a single therapeutic agent while Percocet has two therapeutic agents.
Tylenol vs. Percocet
Tylenol contains acetaminophen whereas Percocet contains oxycodone and acetaminophen.
Tylenol vs. Percocet
Tylenol is used to treat moderate pain, while Percocet is used to treat moderate to severe pain.
Tylenol vs. Percocet
Tylenol is available in single strength while Percocet is available in multiple strengths.
Tylenol vs. Percocet
Tylenol is a remedy for moderate pain. On the other hand, Percocet is a remedy for moderate to severe pain.
Tylenolnoun
The pharmaceutical drug paracetamol}}
Tylenolnoun
A tablet containing this drug
Tylenolnoun
an analgesic for mild pain; also used as an antipyretic; (Datril and Tylenol and Panadol and Phenaphen and Tempra and Anacin III are trademarks of brands of acetaminophen tablets)
Comparison Chart
Tylenol | Percocet |
Tylenol is analgesic and antipyretic containing acetaminophen as an active moiety. | Percocet is the analgesic and combination of Oxycodone and acetaminophen therapeutic moieties. |
Mechanism of Action | |
Tylenol decreases the production of the prostaglandins, which are responsible for pain and inflammation. | Percocet acts by acting on opioid receptors and by decreasing prostaglandins which are responsible for pain and inflammation. |
Route of Administration | |
Tylenol is given orally. | Percocet is given orally |
Available Salts | |
Tylenol contains acetaminophen. | Percocet contains oxycodone HCl and acetaminophen. |
Drug Interactions | |
Tylenolinteract with 182 drugs. | Percocet interact with 1016 drugs. |
Signs of Overdose | |
Liver damage | · Death and difficult breathing |
Therapeutic Uses | |
Treatment of moderate pain | Treatment of moderate to severe pain. |
Tylenol vs. Percocet
Tylenol is the brand name of acetaminophen, on the other hand, Percocet is a brand name of a combination of oxycodone and acetaminophen. Tylenol is available in single strength while Percocet is available in multiple strengths. Tylenol treats moderate pain, whereas Percocet treats moderate to severe pain. Tylenol contains nonopioid analgesic while Percocet contains an opioid analgesic and a non-opioid analgesic. Tylenol shows drug interactions with 182 drugs, while Percocet shows drug interactions with 1016 drugs.
What is Tylenol?
Tylenol is the brand name of and is acetaminophen. Tylenol is used for the treatment of pain and fever. Tylenol is mostly prescribed for moderate pain. Tylenol strength is 500mg. Tylenol’s mechanism of action is not still well known but is considered that it mitigates the production of prostaglandins ( which causes inflammation and swelling) in the brain area. Tylenol can be used maximum for ten days. Tylenol does not treat inflammation of mild arthritis, but it relieves pain in this condition. Tylenol is as effective as ibuprofen to cure the osteoarthritis. Tylenol shows side effects like hypersensitivity reactions to acetaminophen, which produces rashes, nausea, headache, skin reactions, and kidney damage. Tylenol use also led to a decrease in the number of WBC. Tylenol overdose leads to liver toxicity, which worsens the patient condition. Tylenol overdose can cause acute liver failure. Tylenol 500mg is given after every 8hrs. Tylenol is also prescribed to children, 10-15mg/kg is given after every 8hrs if the child is less than 12 years old, but the dose should not exceed 2.6g/day. Tylenol metabolism occurs in the liver, so all those drugs which induce enzymes in the liver increase the metabolism of the Tylenol. Tylenol use in pregnancy does not cause malformations in the baby, but if pregnant women use, then babies suffer from childhood asthma.
What is Percocet?
Percocet is the brand name of the combination of two drugs. Percocet contains oxycodone and acetaminophen, oxycodone is opioid analgesic, and acetaminophen is analgesic and antipyretic. Percocet is used to treat moderate to severe pain. Percocet is used according to guidelines of a pharmacist. Percocet prescription can be refilled according to a recommendation by physician or pharmacist. Percocet is given orally. Percocet is available in different strengths in which the amount of acetaminophen remains the same i-e 325mg, but the strength of the oxycodone changes i-e 2.5mg, 5mg, 7.5mg, and 10mg. Percocet dose depends upon the condition of the patient and the patient’s response to Percocet therapy. Percocet, like all analgesics, works best at the appearance of ist sign of the pain. Percocet therapy can be replaced by the long-acting opioids if the patient condition does not improve. Percocet can be prescribed in combinations to treat the pain. Percocet shows the withdrawal symptoms if stopped suddenly.
ConclusionConclusion of the above discussion is that both Tylenol and Percocet are analgesics and Tylenol is important for use in moderate pain and Percocet for use in moderate to severe pain.