Difference Between Tylenol and Percocet


Main Difference

The main difference between Tylenol and Percocet is that Tylenol is the brand name of analgesic and antipyretic acetaminophen and Percocet is the brand name of opioid analgesic oxycodone and non-opioid analgesic and antipyretic acetaminophen.

Tylenol vs. Percocet

Tylenol is the brand name of acetaminophen, on the other hand, Percocet is a brand name of a combination of oxycodone and acetaminophen. Tylenol is available in single strength while Percocet is available in multiple strengths. Tylenol treats moderate pain, whereas Percocet treats moderate to severe pain. Tylenol contains nonopioid analgesic while Percocet contains an opioid analgesic and a non-opioid analgesic. Tylenol shows drug interactions with 182 drugs, while Percocet shows drug interactions with 1016 drugs.


Comparison Chart

Tylenol is analgesic and antipyretic containing acetaminophen as an active moiety.Percocet is the analgesic and combination of Oxycodone and acetaminophen therapeutic moieties.
Mechanism of Action
Tylenol decreases the production of the prostaglandins, which are responsible for pain and inflammation.Percocet acts by acting on opioid receptors and by decreasing prostaglandins which are responsible for pain and inflammation.
Route of Administration
Tylenol is given orally.Percocet is given orally
Available Salts
Tylenol contains acetaminophen.Percocet contains oxycodone HCl and acetaminophen.
Drug Interactions
Tylenolinteract with 182 drugs.Percocet interact with 1016 drugs.
Signs of Overdose
Liver damage· Death and difficult breathing
Therapeutic Uses
Treatment of moderate painTreatment of moderate to severe pain.

What is Tylenol?

Tylenol is the brand name of and is acetaminophen. Tylenol is used for the treatment of pain and fever. Tylenol is mostly prescribed for moderate pain. Tylenol strength is 500mg. Tylenol’s mechanism of action is not still well known but is considered that it mitigates the production of prostaglandins ( which causes inflammation and swelling) in the brain area. Tylenol can be used maximum for ten days. Tylenol does not treat inflammation of mild arthritis, but it relieves pain in this condition. Tylenol is as effective as ibuprofen to cure the osteoarthritis. Tylenol shows side effects like hypersensitivity reactions to acetaminophen, which produces rashes, nausea, headache, skin reactions, and kidney damage. Tylenol use also led to a decrease in the number of WBC. Tylenol overdose leads to liver toxicity, which worsens the patient condition. Tylenol overdose can cause acute liver failure. Tylenol 500mg is given after every 8hrs. Tylenol is also prescribed to children, 10-15mg/kg is given after every 8hrs if the child is less than 12 years old, but the dose should not exceed 2.6g/day. Tylenol metabolism occurs in the liver, so all those drugs which induce enzymes in the liver increase the metabolism of the Tylenol. Tylenol use in pregnancy does not cause malformations in the baby, but if pregnant women use, then babies suffer from childhood asthma.

What is Percocet?

Percocet is the brand name of the combination of two drugs. Percocet contains oxycodone and acetaminophen, oxycodone is opioid analgesic, and acetaminophen is analgesic and antipyretic. Percocet is used to treat moderate to severe pain. Percocet is used according to guidelines of a pharmacist. Percocet prescription can be refilled according to a recommendation by physician or pharmacist. Percocet is given orally. Percocet is available in different strengths in which the amount of acetaminophen remains the same i-e 325mg, but the strength of the oxycodone changes i-e 2.5mg, 5mg, 7.5mg, and 10mg. Percocet dose depends upon the condition of the patient and the patient’s response to Percocet therapy. Percocet, like all analgesics, works best at the appearance of ist sign of the pain. Percocet therapy can be replaced by the long-acting opioids if the patient condition does not improve. Percocet can be prescribed in combinations to treat the pain. Percocet shows the withdrawal symptoms if stopped suddenly.

Key Differences

  1. Tylenol has a single therapeutic agent while Percocet has two therapeutic agents.
  2. Tylenol contains acetaminophen whereas Percocet contains oxycodone and acetaminophen.
  3. Tylenol is used to treat moderate pain, while Percocet is used to treat moderate to severe pain.
  4. Tylenol is available in single strength while Percocet is available in multiple strengths.
  5. Tylenol is a remedy for moderate pain. On the other hand, Percocet is a remedy for moderate to severe pain.


Conclusion of the above discussion is that both Tylenol and Percocet are analgesics and Tylenol is important for use in moderate pain and Percocet for use in moderate to severe pain.

Janet White

Janet White is a writer and blogger for Difference Wiki since 2015. She has a master's degree in science and medical journalism from Boston University. Apart from work, she enjoys exercising, reading, and spending time with her friends and family. Connect with her on Twitter @Janet__White