Zantac vs. Nexium

Main Difference

The main difference between Zantac and Nexium that Zantac is H-2 receptor blocker and Nexium is proton pump inhibitor.

Zantac vs. Nexium — Is There a Difference?

Difference Between Zantac and Nexium

Zantac vs. Nexium

Zantac is an H-2 receptor antagonist while Nexium is proton pump inhibitors.

Zantac vs. Nexium

Zantac does not bind extensively to proteins; on the other hand, Nexium is extensively protein-bound drug.

Zantac vs. Nexium

Zantac is available in its active form while Nexium is available as a prodrug which becomes active in an acidic environment.

Zantac vs. Nexium

Zantac is not available in packet form while Nexium is available in packet form.


a histamine blocker and antacid (trade name Zantac) used to treat peptic ulcers and gastritis and esophageal reflux


Comparison Chart

Zantac is the brand name of H-2 receptor blocker ranitidine.Nexium is the generic name of esomeprazole
Receptors at Which Drug Acts
Zantac acts on H-2 receptorsNexium acts on proton pumps.
Mode of Action
Zantac is mild gastric acid suppressor as compared to omeprazole.Nexium is a potent gastric acid suppressor.
Protein Binding of Drug
A small percentage of Zantac is protein bound.A large percentage of Nexium is protein bound.
Available Dosage Forms
Pill, Injections, Syrup, SolutionPill, Injection, Packet
Therapeutic Uses
Heart Burn
Gastric Ulcers
Duodenal Ulcers
Stress Ulcers
Heart Burn
Gastric Ulcers
H.Pylori Infection
NSAID induced Gastric Ulcers

Zantac vs. Nexium

Zantac is H-2 receptor blocker having generic drug ranitidine; on the other hand, Nexium is a proton pump inhibitor having generic drug esomeprazole. Zantac relieves heartburn and stomach ulcers with few side effects, while Nexium relieves heartburn and stomach ulcers with side effects shown in the long term. Zantac pills if are difficult to swallow then Zantac liquid preparations are available while Nexium pills if are difficult to swallow then Nexium packets are available. Zantac is preferably prescribed for duodenal ulcers; on the other hand, Nexium is preferably prescribed for H.Pylori infection. Zantac is both prescription and over the counter drug, while Nexium is just over the counter drug.

What is Zantac

Zantac contains ranitidine as an active therapeutic agent. Zantac belongs to H2 receptor antagonist. Zantac can suppress about 70% of the gastric acid secretions in 24hrs. Zantac can inhibit basal acid secretion. Zantac is also used to suppress nocturnal acid secretion. Zantac has also found its use in the treatment of the duodenal ulcers as it suppresses the nocturnal acidity, so it is prescribed at evening times to treat duodenal ulcers. Zantac is also found to increases the GI motility. Zantac is an over the counter drug. Zantac is rapidly absorbed after oral administration. Peak serum concentration is reached in 1-3 hrs. Zantac is more rapidly absorbed in the presence of food. Zantac absorption is decreased if there is any antacid. Approximately 10% -35% of the Zantac is metabolized in the liver. Zantac and its metabolites are excreted by the kidney. The excretion through kidneys is important for the dose adjustment of Zantac in kidney patients. Minor side effects like headache, drowsiness, muscular pain, and diarrhea are shown by Zantac. Zantac effects CNS and causes slurred speech. Zantac is reported for the blood dyscrasias. Zantac can cross the placenta and also excretes in breast milk. Zantac as compared to other H2 receptor antagonists interferes less with hepatic metabolism of other drugs. Zantac along with treating gastric and duodenal ulcers also prevents the occurrence of stress ulcers.


Zantac enteric-coated tablets and injects.

What is Nexium

Nexium is the Proton pump inhibitor which are potent suppressors of gastric acid secretions. Nexium inhibits basal and stimulated secretion of gastric acid. Nexium is S-isomer of omeprazole. Nexium is eliminated less rapidly than R isomer of Omeprazole. Nexium has increased half-life. Nexium is available in the form of a prodrug, which changes into an active form in the presence of the acidic environment. Nexium is acid labile, to address this issue it is available as enteric-coated drugs and packet Nexium in combination with sodium carbonate. Nexium shows less absorption in the presence of food. Nexium has high protein-bound concentration. Nexium is metabolized by the hepatic enzymes. Nexium reaches to peak plasma concentration in 2-4 hrs. Nexium shows adverse effects like headaches, dark urine, constipation. Nexium treats gastric ulcers, H.Pylori infections, gastroesophageal reflux disease, and Zollinger Ellison syndrome.


Nexium is available as pills, injections, and packet form.


The conclusion of the above discussion is that Zantac and Nexium both belong to two different drug categories, but both are used to suppress gastric acid secretions.