Unisom vs. Benadryl: What's the Difference?

Edited by Huma Saeed || By Sumera Saeed || Updated on October 15, 2023
Unisom is primarily a sleep aid, while Benadryl is an antihistamine used for allergies; both can cause drowsiness.

Key Differences
Unisom and Benadryl are both over-the-counter medications. While Unisom is primarily marketed as a sleep aid, Benadryl is most commonly known as an antihistamine for allergies. Both have the potential side effect of causing drowsiness, which is why Unisom can be used to help with insomnia.

Sumera Saeed
Oct 15, 2023
Both Unisom and Benadryl have diphenhydramine as an active ingredient in some of their formulations. However, the primary intention behind their marketing is different. Unisom aims to address sleeplessness, while Benadryl's primary purpose is to relieve allergy symptoms.

Sumera Saeed
Oct 15, 2023
It's essential to note that while Unisom and Benadryl may have similar effects, they are not always interchangeable. Using Benadryl solely as a sleep aid might not be recommended, and it's crucial to understand the intended purpose and dosage of each medication.

Sumera Saeed
Oct 15, 2023
Lastly, it's always advisable to consult with a healthcare professional before taking either Unisom or Benadryl. Since both medications can cause drowsiness, operating heavy machinery or driving after consumption might not be advisable.

Sumera Saeed
Oct 15, 2023
Comparison Chart
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Available Formulations
Tablets, softgels, liquid
Tablets, liquid, topical creams, gels

Sumera Saeed
Oct 15, 2023
Recommended for Children
Not typically without consultation
Yes, with pediatric formulations

Aimie Carlson
Oct 15, 2023
Unisom and Benadryl Definitions
Unisom
A product containing doxylamine or diphenhydramine.
The pharmacist recommended Unisom with doxylamine for my sleep issue.

Sumera Saeed
Oct 15, 2023
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Benadryl
A brand-name medication for allergy relief.
When pollen season starts, I stock up on Benadryl.

Sumera Saeed
Oct 15, 2023
Unisom
A non-prescription drug for sleeplessness.
He buys Unisom whenever he's facing jet lag.

Janet White
Oct 15, 2023
Benadryl
A drug commonly used for allergic reactions.
After the bee sting, he quickly took some Benadryl.

Sara Rehman
Oct 15, 2023
Unisom
An over-the-counter medication for insomnia.
She uses Unisom occasionally to combat her sleepless nights.

Huma Saeed
Oct 15, 2023
Benadryl
An over-the-counter antihistamine.
I always carry Benadryl for my sudden allergy attacks.

Huma Saeed
Oct 15, 2023
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Benadryl
A product containing diphenhydramine.
This itch relief cream has Benadryl in it.

Sara Rehman
Oct 15, 2023
Unisom
A remedy often suggested for occasional sleep problems.
My doctor said I could try Unisom for those nights I can't drift off.

Aimie Carlson
Oct 15, 2023
Benadryl
A remedy that can induce drowsiness.
I avoid taking Benadryl during the day because it makes me sleepy.

Sara Rehman
Oct 15, 2023
Benadryl
Antihistamine (trade name Benadryl) used to treat allergic reactions involving the nasal passages (hay fever) and also to treat motion sickness

Sumera Saeed
Aug 16, 2019
FAQs
What is the main ingredient in some Unisom products?
Doxylamine or diphenhydramine, depending on the formulation.

Sumera Saeed
Oct 15, 2023
Can Benadryl help with sleep?
Yes, drowsiness is a side effect, so some people use it for sleep.

Janet White
Oct 15, 2023
What is Benadryl primarily used for?
Benadryl is primarily used as an antihistamine for allergies.

Janet White
Oct 15, 2023
Can children take Benadryl?
Yes, there are pediatric formulations of Benadryl.

Harlon Moss
Oct 15, 2023
Can I develop a tolerance to Benadryl if I take it regularly?
There is a potential for tolerance with frequent use, which may reduce its effectiveness. Consult a doctor for long-term use.

Harlon Moss
Oct 15, 2023
Can elderly individuals take Unisom or Benadryl?
Elderly individuals may be more sensitive to side effects. It's crucial to consult with a healthcare professional regarding appropriate dosages.

Aimie Carlson
Oct 15, 2023
How long does the drowsy effect of Unisom typically last?
The drowsy effect of Unisom can last for several hours, and it's advised not to operate machinery or drive during this time.

Sumera Saeed
Oct 15, 2023
Can I take Benadryl for a cold or cough?
Benadryl is primarily an antihistamine for allergies, but it may help with cold symptoms. Consult a healthcare professional for appropriate treatments.

Harlon Moss
Oct 15, 2023
Are there any common side effects of Unisom besides drowsiness?
Some common side effects include dry mouth, dizziness, and headache. Always refer to the product label or consult a pharmacist.

Sumera Saeed
Oct 15, 2023
Can I take Unisom or Benadryl with alcohol?
Combining alcohol with either Unisom or Benadryl can intensify drowsiness and is not recommended.

Sumera Saeed
Oct 15, 2023
Are there any known drug interactions with Unisom or Benadryl?
Yes, both medications can interact with other drugs. Always consult with a healthcare professional before starting a new medication.

Janet White
Oct 15, 2023
Can I give my pet Benadryl for allergies?
While some veterinarians prescribe Benadryl for pets, always consult with them before giving any human medications to animals.

Aimie Carlson
Oct 15, 2023
Can Unisom help with allergies?
No, Unisom is not marketed as an allergy medication.

Huma Saeed
Oct 15, 2023
Are there non-drowsy versions of Benadryl?
While some antihistamines offer non-drowsy versions, traditional Benadryl can cause drowsiness.

Sumera Saeed
Oct 15, 2023
Are Unisom and Benadryl available over-the-counter?
Yes, both Unisom and Benadryl are available over-the-counter.

Harlon Moss
Oct 15, 2023
Is it safe to take Unisom and Benadryl together?
It's essential to consult with a healthcare professional before mixing medications.

Aimie Carlson
Oct 15, 2023
Why might someone choose Unisom over Benadryl for sleep?
Unisom is specifically marketed and formulated as a sleep aid.

Sumera Saeed
Oct 15, 2023
Can pregnant or breastfeeding women take Unisom or Benadryl?
It's essential to consult with a healthcare professional before taking any medication during pregnancy or breastfeeding.

Sumera Saeed
Oct 15, 2023
About Author
Written by
Sumera SaeedSumera is an experienced content writer and editor with a niche in comparative analysis. At Diffeence Wiki, she crafts clear and unbiased comparisons to guide readers in making informed decisions. With a dedication to thorough research and quality, Sumera's work stands out in the digital realm. Off the clock, she enjoys reading and exploring diverse cultures.

Edited by
Huma SaeedHuma is a renowned researcher acclaimed for her innovative work in Difference Wiki. Her dedication has led to key breakthroughs, establishing her prominence in academia. Her contributions continually inspire and guide her field.
