Difference Between Zantac and Pepcid

Main Difference

The main difference between Zantac and Pepcid is that Zantac contains the ranitidine as therapeutic moiety and Pepcid contains the famotidine as a therapeutic moiety.

Zantac vs. Pepcid

Zantac is the brand name of ranitidine; on the other hand, Pepcid is the brand name of Famotidine. Zantac salt is ranitidine hydrochloride while Pepcid salt is famotidine. Zantac lowers the levels of vitamin B12 if used for a long time; on the other hand, Pepcid does not lower the levels of vitamin B12 if used for a long time. Zantac is available as a pill, oral solution, oral syrup, and injection, on the other hand, Pepcid is available as the pill, chewable tablet, and liquid. Zantac is of low cost relatively; on the other hand, Pepcid is of high price relatively. Zantac causes swollen or tender breasts in women; on the other hand, Pepcid does not causes swollen or tender breasts in women.

Comparison Chart

ZantacPepcid
Zantac is the brand containing ranitidine.Pepcid is the brand containing the famotidine.
Drug Group
H2 Receptor antagonistH2 Receptor antagonist
Active Therapeutic Agent
Ranitidine hydrochlorideFamotidine
On the set of Action
Fast in actionSlow in action
Mechanism of Action
Inhibits acid production by blocking the H2 receptors.Inhibits acid production by blocking the H2 receptors.
Side Effects
Diarrhea, Constipation, Fatigue, Headache, Importance, Muscle pain, Stomach pain, Swollen or tender breasts, etcMood changes, Insomnia, Joint pain, Diarrhea, Constipation, Muscle pain, Dry mouth, etc
Therapeutic uses
Zollinger Ellison syndrome, erosive esophagitis, and gastroesophageal reflux disease, Stomach, and Duodenal ulcersIndigestion, Zollinger Ellison syndrome, erosive esophagitis, and gastroesophageal reflux disease, Stomach, and Duodenal ulcers

What is Zantac?

Zantac Contains the ranitidine. Zantac blocks acid production by blocking the H2 receptors. Zantac relieves the symptoms of the sour stomach, acid indigestion, and heartburn. Zantac also used in Zollinger Ellison syndrome, erosive esophagitis and gastroesophageal reflux disease Zantac can be taken for both the treatment and prevention of the symptoms of excess acid. To relieve the symptoms in adults and children of age 12 or above Zantac single tablet can be taken with a glass of water and to prevent the symptoms Zantac single tablet can be taken 30-60 minutes before the food. The maximum number of tablets that can be used by adults and children of age 12 and above is 2. It is strongly recommended that do not use more than two tablets of the Zantac. For the dose of children who are under the age of 12 consults a doctor or prescriber who will calculate the dose according to symptoms of child and his age or gender. Zantac is stored at a temperature of 20-25 degree. Zantac exposure to heat or humidity is avoided. Zantac is sodium and sugar-free. Zantac and its metabolites are excreted by the liver and kidney so in case of any disease of liver and kidney the dose of Zantac is adjusted. Zantac absorption is enhanced by food and is decreased in the presence of the antacid.

What is Pepcid?

Pepcid contains the famotidine, which is H2 receptor blocker. Pepcid blocks the acid production because it competes with the histamine for H2 receptors binding on membranes of parietal cells. Pepcid is used to treat the stomach and intestine ulcers. Pepcid also prevents the intestine ulcers once they have healed. Pepcid also treats some other medical conditions like the Zollinger Ellison syndrome, erosive esophagitis, and gastroesophageal reflux disease. Pepcid decreases stomach acid production. Pepcid relieves the persistent cough. Pepcid treats stomach pain, heartburn, and difficulty in swallowing. Pepcid is over the counter drug. Pepcid is used for the self-treatment then the patient must check the manufacture,s package instructions completely and carefully before its use. Pepcid can be taken with or without food. Pepcid can be taken once or twice depending upon the worsening of symptoms of the disease. Incase if the Pepcid is taken once daily, then the patient must take it at the bedtime. The total dose of Pepcid is calculated keeping in mind the medical situations of the patient, its gender and in case of the children body weight is also an important factor for the calculation of the dose of the Pepcid. Pepcid intake regularly increases its benefits and take this drug regularly at the same time. Pepcid intake should not be stopped without the recommendation of the prescriber. For the treatment of heartburn take this medication with one glass of water but for the prevention of the heartburn take this medicine 15-60 minutes before taking food. Patients should not use more than two tablets in 24 hrs.

Key Differences

  1. Zantac is the trade name of the ranitidine; on the other hand, Pepcid is the trade name of the famotidine.
  2. Zantac is ranitidine hydrochloride while Pepcid is famotidine.
  3. Zantac uses leads to lower levels of vitamin B12 other hand Pepcid use does not lead to lower levels of vitamin B12.
  4. Zantac use in women causes swollen and tender breasts whereas Pepcid use in women does not cause swollen and tender breasts
  5. Zantac pill, oral solution, oral syrup, and injection are available other hand Pepcid pill, chewable tablet, and liquid are available.
  6. Zantac is comparatively of a low price, on the other hand, Pepcid is comparatively of the high price.

Conclusion

The main conclusion of the above discussion is that both Zantac and Pepcid are H2 receptor blockers and are used to treat the stomach, duodenal ulcers and all those medical conditions which are due to high stomach acid production.

Janet White

Janet White is a writer and blogger for Difference Wiki since 2015. She has a master's degree in science and medical journalism from Boston University. Apart from work, she enjoys exercising, reading, and spending time with her friends and family. Connect with her on Twitter @Janet__White

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