Difference Between Rizatriptan and Sumatriptan

Main Difference

The main difference between Rizatriptan and Sumatriptan is that Rizatriptan has more advantages in the treatment of Acute migraine and Sumatriptan has relatively fewer advantages in the treatment of Acute Migraine

Rizatriptan vs. Sumatriptan

Rizatriptan is ist line treatment for the migraine headaches while Sumatriptan is an excellent choice for acute migraine headaches. Rizatriptan is available as Rizatriptan benzoate, on the other hand, Sumatriptan Sumatriptan succinate. Rizatriptan can be recommended for tension-type headaches, on the other hand, Sumatriptan is not used for tension-type headaches Rizatriptan achieves peak plasma concentration in 1-1.5 hrs when the drug is taken orally while Sumatriptan achieves peak plasma concentration in 1-2 hrs when the drug is taken orally. Rizatriptan has an oral bioavailability of 45%; on the other hand, Sumatriptan has an oral bioavailability of 14%-17%. Rizatriptan is administered orally whereas Sumatriptan is administered as oral, nasal and subcutaneous preparations.

Comparison Chart

RizatriptanSumatriptan
Rizatriptan is a triptan drug used to treat the migraine headaches and available as Rizatriptan benzoate.Sumatriptan is triptan which treats the migraine headaches and available as Sumatriptan succinate.
Mechanism
5HT receptor agonist5HT receptor agonist
Route of Administration
OralOral, Nasal, Subcutaneous
Rebound Headaches
If used excessively can cause rebound headachesIf used excessively can cause rebound headaches
Dose Frequency
The 2nd dose can be taken after 2hrs of ist dose.The 2nd dose can be taken after 1 hr of ist dose.
Adverse Effects
Asthenia, Fatigue, Flushing, Pain in Chest, Neck, and Jaw, DizzinessAsthenia, Bitter Taste, Fatigue, Flushing, Pain in Chest, Neck, and Jaw, Atrial and Ventricular Arrhythmias, Dizziness

What is Rizatriptan?

Rizatriptan is a triptan drug used to treat migraine headaches. Rizatriptan is taken orally. Rizatriptan acts at serotonin receptors and causes vasoconstriction. Rizatriptan inhibits the release of calcitonin gene-related peptide in the trigeminal nerve. Rizatriptan dose should be taken as soon as the headache starts. If Rizatriptan is used in excessive doses, then it leads to medication overuse headaches. The adverse effects of Rizatriptan are dizziness, dry mouth, tingling, and chest pain. Some other side effects are high blood pressure, stroke, myocardial infarction, serotonin syndrome, and anaphylaxis. Rizatriptan is not used in pregnancy and during breastfeeding is not allowed after 24 hrs of taking Rizatriptan. Rizatriptan does not reduce the number of attacks of the migraine. Rizatriptan is not recommended for headaches, which result due to tension. Rizatriptan can not be taken by the patients who have a problem with the heart. Rizatriptan should not be used before and after 24hrs of migraine. Rizatriptan should not be used within 14 days of the dose of MAO inhibitors. Rizatriptan can be taken with or without the food, but its absorption is fast in an empty stomach. If symptoms are still there after the use of Rizatriptan, then the medicine should not be taken further. If symptoms are relieved partly then headaches, come back, and in this case, the next dose is taken after the 2 hrs of ist dose. Rizatriptan is given in single dose to children or is given as 5mg in the 24hrs period. Rizatriptan should be given with caution to patients who are allergic to Rizatriptan. Rizatriptan can cause drowsiness or dizziness.

What is Sumatriptan?

Sumatriptan is an agonist at the 5-HT receptor, and it inhibits the calcitonin gene-related peptide. Sumatriptan decreases the activity of the trigeminal nerve. Sumatriptan being the member of triptans, treats the migraines and is used excessively in treatment of acute migraines. Sumatriptan is taken orally, topically through the nose and parenterally as injections under the skin. When Sumatriptan is given subcutaneously, the peak plasma concentration is reached after 12 minutes of dose, and Sumatriptan has a bioavailability of 97% after the subcutaneous dose. Bioavailability after nasal spray and oral administration of Sumatriptan is 14% -17%. Sumatriptan has an elimination half-life of 1-2 hrs. Sumatriptan is metabolized by MAO-A mostly, and its metabolites are excreted in the urine. Subcutaneous 6mg dose of Sumatriptan relieves a headache in 70% of patients. Oral and nasal doses of Sumatriptan are also effective; the onset of action after nasal doses are approximately 15 minutes. The oral dose of Sumatriptan is 25mg to 100mg, and after ist dose, the next oral dose can be taken after 2 hrs, and in the 24hrs period, the total 200mg oral dose can be taken. For nasal spray 5mg to 20mg of Sumatriptan is given and nasal dose can be repeated after 2hrs and in 24 hrs total nasal dose of 40mg can be given to patients. Sumatriptan causes rare but severe cardiac events like coronary artery vasospasm, atrial and ventricular arrhythmias, myocardial infarction, and transient myocardial ischemia. 80% of patients experience at least one side effect after a subcutaneous dose of Sumatriptan. Sumatriptan subcutaneous injections also cause mild pain and stinging sensation at the site of injection. The bitter taste is the most common adverse effect after a nasal dose of Sumatriptan. Sumatriptan is contraindicated in patients of ischemic and vasospastic coronary artery disease.

Key Differences

  1. Rizatriptan is available as Rizatriptan benzoate on the other hand Sumatriptan
  2. Rizatriptan finds its use in acute migraines and for tension-type headaches while Sumatriptan is preferably treated only acute migraines.
  3. Rizatriptan tablets are available, on the other hand, Sumatriptan is available as tablets, nasal sprays, and subcutaneous injections.
  4. Rizatriptan achieves peak plasma concentration in 1-1.5 hrs after oral dose while Sumatriptan achieves peak plasma concentration in 1-2 hrs after an oral dose.
  5. Rizatriptan attains oral bioavailability of 45%, on the other hand, Sumatriptan attains oral bioavailability of 14%-17%.

Conclusion

The main conclusion of the above discussion is that Rizatriptan and Sumatriptan belong to triptans and are used for the treatment of acute migraines.

Janet White

Janet White is a writer and blogger for Difference Wiki since 2015. She has a master's degree in science and medical journalism from Boston University. Apart from work, she enjoys exercising, reading, and spending time with her friends and family. Connect with her on Twitter @Janet__White

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