Rizatriptan vs. Sumatriptan: What's the Difference?
Edited by Huma Saeed || By Sumera Saeed || Updated on October 17, 2023
Rizatriptan and sumatriptan are both medications used to treat migraine attacks, but they differ in their chemical structure, onset of action, and side effects.
Key Differences
Rizatriptan and sumatriptan are both triptans, a class of medications specifically used to treat migraines. Rizatriptan, known under the brand name Maxalt, is praised for its quick onset of action, often relieving pain within 2 hours of ingestion. Sumatriptan, marketed as Imitrex among others, was the first triptan developed and has been a crucial medication in migraine management since the early 1990s. Both are selective serotonin receptor agonists, meaning they target serotonin receptors in the brain to alleviate migraine symptoms.
Sumera Saeed
Oct 17, 2023
When it comes to administration, rizatriptan is available in tablets and orally disintegrating tablets, making it versatile and convenient for different patient preferences. Sumatriptan offers more varied forms, including tablets, nasal spray, and subcutaneous injections. The diversity in sumatriptan's administration methods allows for flexibility in addressing varying degrees of migraine severity and patient comfort levels.
Sumera Saeed
Oct 17, 2023
The side effect profiles of rizatriptan and sumatriptan also warrant consideration. Common side effects for rizatriptan include dizziness, fatigue, and tightness in the chest or throat. Sumatriptan shares many of these side effects but is more frequently associated with sensations of tingling or warmth. Both medications can raise blood pressure and are contraindicated in patients with certain cardiovascular conditions.
Sumera Saeed
Oct 17, 2023
Speaking of efficacy, both rizatriptan and sumatriptan are effective for migraine relief, but individual responses can vary. Rizatriptan is often highlighted for its rapid relief, usually effective within 2 hours. Sumatriptan's effectiveness can depend on the form; for example, the injection can provide relief within 10-15 minutes, much faster than its oral form.
Sumera Saeed
Oct 17, 2023
Lastly, cost and accessibility are significant factors in choosing between rizatriptan and sumatriptan. Sumatriptan, being older, is typically more affordable and widely available as a generic. Rizatriptan is also available generically, but might sometimes be more expensive than sumatriptan. The choice often depends on individual health insurance coverage and specific patient medical history.
Sumera Saeed
Oct 17, 2023
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Comparison Chart
Word Origin
Derived from "triptan," signifying its class; "riza" offers no specific linguistic meaning.
"Suma-" lacks clear meaning, while "-triptan" denotes its drug class.
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Oct 17, 2023
Position in Alphabet
R is the 18th letter, earlier in the alphabet.
S is the 19th letter, following R.
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Oct 17, 2023
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Rizatriptan and Sumatriptan Definitions
Rizatriptan
Rizatriptan belongs to the triptan drug class, working by narrowing blood vessels around the brain.
Rizatriptan effectively eased his symptoms by restricting blood flow in the cranial vessels.
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Oct 17, 2023
Sumatriptan
Sumatriptan's availability in various forms—pills, nasal spray, and injection—accommodates diverse patient needs.
Her nausea during migraines made the sumatriptan nasal spray a preferable option.
Sumera Saeed
Oct 17, 2023
Rizatriptan
Rizatriptan is a medication prescribed for the treatment of acute migraine attacks.
The doctor recommended rizatriptan to manage her sudden migraine episodes.
Huma Saeed
Oct 17, 2023
Sumatriptan
Sumatriptan, a member of the triptan class, functions by constricting blood vessels in the brain.
The vascular constriction induced by sumatriptan alleviated his throbbing headache.
Sumera Saeed
Oct 17, 2023
Rizatriptan
Rizatriptan may induce side effects like dizziness, fatigue, or throat tightness in some patients.
Although rizatriptan relieved her migraines, she experienced noticeable drowsiness post-dosage.
Harlon Moss
Oct 17, 2023
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Sumatriptan
Sumatriptan's common side effects include sensations of warmth or tingling and dizziness.
After taking sumatriptan, she often felt a slight warmth spreading across her forehead.
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Oct 17, 2023
Rizatriptan
Rizatriptan can be administered orally, appealing to individuals who prefer not to use injections or nasal sprays.
Due to his aversion to needles, rizatriptan's oral tablets presented an ideal solution.
Harlon Moss
Oct 17, 2023
Sumatriptan
Sumatriptan is a medication used for treating migraines and cluster headaches.
Sumatriptan was her first line of defense against recurrent migraine attacks.
Huma Saeed
Oct 17, 2023
Rizatriptan
Rizatriptan is recognized for its rapid onset, often providing relief within 2 hours of consumption.
Her migraines, once debilitating, were quickly subdued with the prompt effectiveness of rizatriptan.
Sumera Saeed
Oct 17, 2023
Sumatriptan
Sumatriptan provides rapid relief, especially the injectable form, effective within 10-15 minutes.
Faced with sudden, severe migraines, he found solace in sumatriptan's quick-acting injection.
Sara Rehman
Oct 17, 2023
Rizatriptan
An oral drug of the triptan class, C15H19N5, used in its benzoate form to treat migraine headaches.
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Jul 04, 2019
Sumatriptan
A triptan drug, C14H21N3O2S, used also in the form of its succinate to treat migraine headache and cluster headache.
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Jul 04, 2019
FAQs
What are rizatriptan and sumatriptan?
Both rizatriptan and sumatriptan are medications used primarily for treating acute migraine headaches.
Sumera Saeed
Oct 17, 2023
Can rizatriptan and sumatriptan be taken daily?
Both rizatriptan and sumatriptan are intended for acute migraine attacks, not daily preventative use.
Harlon Moss
Oct 17, 2023
What are the common side effects of rizatriptan and sumatriptan?
Rizatriptan can cause dizziness and fatigue, while sumatriptan may cause tingling, warmth, or dizziness.
Sara Rehman
Oct 17, 2023
How do rizatriptan and sumatriptan work?
Rizatriptan and sumatriptan work by constricting blood vessels in the brain and blocking certain pain pathways.
Huma Saeed
Oct 17, 2023
Are there people who shouldn't take rizatriptan or sumatriptan?
Individuals with certain cardiovascular conditions should avoid both rizatriptan and sumatriptan.
Harlon Moss
Oct 17, 2023
Are rizatriptan and sumatriptan available in multiple forms?
Rizatriptan is generally available in tablet form, while sumatriptan comes in tablets, nasal sprays, and injections.
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Oct 17, 2023
Can I use rizatriptan or sumatriptan for tension headaches?
Rizatriptan and sumatriptan are specifically designed for migraines, not tension headaches.
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Oct 17, 2023
Are rizatriptan and sumatriptan over-the-counter drugs?
Both rizatriptan and sumatriptan require a prescription in the United States.
Sara Rehman
Oct 17, 2023
Can I take rizatriptan or sumatriptan during pregnancy?
The safety of rizatriptan and sumatriptan during pregnancy is uncertain; consult your healthcare provider.
Harlon Moss
Oct 17, 2023
Can I drink alcohol while taking rizatriptan or sumatriptan?
Alcohol may exacerbate the side effects of both rizatriptan and sumatriptan; it's best to avoid it.
Sara Rehman
Oct 17, 2023
How fast do rizatriptan and sumatriptan work?
Rizatriptan typically works within 2 hours; sumatriptan's effect time varies by form, with injections being the fastest.
Aimie Carlson
Oct 17, 2023
Do rizatriptan and sumatriptan have generic versions?
Yes, both medications are available in generic form.
Janet White
Oct 17, 2023
Can I take rizatriptan and sumatriptan together?
Combining rizatriptan and sumatriptan is not recommended due to increased risk of side effects.
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Oct 17, 2023
Will rizatriptan or sumatriptan affect my birth control?
There's no evidence that rizatriptan or sumatriptan interferes with hormonal birth control.
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Oct 17, 2023
Is it safe to drive after taking rizatriptan or sumatriptan?
Dizziness is a side effect of both rizatriptan and sumatriptan, so driving may be unsafe after taking them.
Sumera Saeed
Oct 17, 2023
Do rizatriptan and sumatriptan interact with other drugs?
Yes, both can interact with certain antidepressants and other medications; provide your doctor with a full medical history before use.
Harlon Moss
Oct 17, 2023
What should I do if I miss a dose of rizatriptan or sumatriptan?
Both rizatriptan and sumatriptan are taken as needed for migraines, so there's no issue with "missing" a dose.
Sumera Saeed
Oct 17, 2023
Are rizatriptan and sumatriptan addictive?
Neither rizatriptan nor sumatriptan is known to be addictive, but they should be used as directed by a physician.
Sara Rehman
Oct 17, 2023
Can rizatriptan or sumatriptan cause weight gain?
Weight gain is not a commonly reported side effect of either rizatriptan or sumatriptan.
Harlon Moss
Oct 17, 2023
How are rizatriptan and sumatriptan metabolized in the body?
Both rizatriptan and sumatriptan are primarily metabolized by the liver.
Sumera Saeed
Oct 17, 2023
About Author
Written by
Sumera SaeedSumera is an experienced content writer and editor with a niche in comparative analysis. At Diffeence Wiki, she crafts clear and unbiased comparisons to guide readers in making informed decisions. With a dedication to thorough research and quality, Sumera's work stands out in the digital realm. Off the clock, she enjoys reading and exploring diverse cultures.
Edited by
Huma SaeedHuma is a renowned researcher acclaimed for her innovative work in Difference Wiki. Her dedication has led to key breakthroughs, establishing her prominence in academia. Her contributions continually inspire and guide her field.
