Naproxen vs. Tramadol: What's the Difference?

Edited by Huma Saeed || By Sumera Saeed || Updated on October 30, 2023
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used for pain and inflammation relief. Tramadol is an opioid-like pain reliever primarily for moderate to severe pain.

Key Differences
Naproxen and tramadol are two distinct medications used primarily for pain management. Naproxen belongs to the nonsteroidal anti-inflammatory drug (NSAID) class. It works by reducing the production of hormones causing inflammation and pain in the body. In contrast, tramadol is an opioid-like pain reliever. It functions by altering the brain's perception and response to pain, acting on specific neurotransmitters.

Sumera Saeed
Oct 28, 2023
Though both naproxen and tramadol can be prescribed for pain, their specific use cases vary. Naproxen is often prescribed for conditions like arthritis, menstrual cramps, or other pain resulting from inflammation. Tramadol, on the other hand, is used for moderate to severe pain conditions. Its efficacy in addressing pain is higher compared to regular NSAIDs.

Sumera Saeed
Oct 28, 2023
When comparing side effects, naproxen, like other NSAIDs, can lead to stomach ulcers, heart problems, or kidney issues if taken for prolonged periods or in high doses. Tramadol, being an opioid-like substance, carries risks like respiratory depression, addiction, or overdose. Both drugs require monitoring by healthcare professionals to ensure safety.

Sumera Saeed
Oct 28, 2023
While naproxen can be found over-the-counter in lower doses, it's also available via prescription in higher doses. Tramadol, however, is strictly prescription-only due to its potential for misuse and dependence. When using either drug, it's essential to follow the recommended dosages and be aware of potential drug interactions.

Janet White
Oct 28, 2023
Comparison Chart
Drug Class
Nonsteroidal anti-inflammatory drug (NSAID)
Opioid-like pain reliever

Sumera Saeed
Oct 28, 2023
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Mechanism of Action
Reduces hormones causing pain and inflammation
Alters brain's perception and response to pain

Sumera Saeed
Oct 28, 2023
Risk of Side Effects
Stomach ulcers, heart problems, kidney issues
Respiratory depression, addiction, overdose

Janet White
Oct 28, 2023
Naproxen and Tramadol Definitions
Naproxen
An NSAID used to treat pain.
The doctor recommended naproxen for her arthritis pain.

Huma Saeed
Oct 28, 2023
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Tramadol
An opioid-like medication for pain relief.
Tramadol was prescribed after his surgery to manage pain.

Huma Saeed
Oct 28, 2023
Naproxen
A drug that reduces inflammation.
Naproxen helped reduce the swelling in his injured ankle.

Harlon Moss
Oct 28, 2023
Tramadol
Alters the brain's perception of pain.
Thanks to tramadol, he felt significantly less discomfort.

Harlon Moss
Oct 28, 2023
Naproxen
Available in both prescription and over-the-counter strengths.
For mild headaches, she takes over-the-counter naproxen.

Janet White
Oct 28, 2023
Tramadol
Used primarily for moderate to severe pain.
In cases where NSAIDs are ineffective, tramadol might be considered.

Sara Rehman
Oct 28, 2023
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Naproxen
Can be used for various pain-related conditions.
Naproxen is effective for menstrual cramps and muscle strains.

Janet White
Oct 28, 2023
Tramadol
Carries a risk of dependency and overdose.
Patients must strictly follow the prescribed tramadol dose.

Sara Rehman
Oct 28, 2023
Naproxen
Has potential gastrointestinal side effects.
Taking naproxen without food can upset the stomach.

Harlon Moss
Oct 28, 2023
Tramadol
Available strictly via prescription.
Due to its potential for misuse, tramadol isn't sold over-the-counter.

Aimie Carlson
Oct 28, 2023
Naproxen
A nonsteroidal anti-inflammatory drug, C14H14O3, used to treat fever and pain.

Sumera Saeed
Jul 30, 2019
Tramadol
A synthetic analgesic, C16H25NO2, used in its hydrochloride form to treat moderate to moderately severe pain. It is structurally similar to codeine and has both opioid and nonopioid effects.

Sumera Saeed
Jul 30, 2019
Naproxen
(pharmacology) A certain non-steroidal anti-inflammatory drug that inhibits the COX-1 and COX-2 enzymes and thereby reduces pain, fever, inflammation, and stiffness.

Sumera Saeed
Jul 30, 2019
Tramadol
(pharmaceutical drug) A synthetic opioid analgesic administered orally in the form of its hydrochloride C16H25NO2·HCl to treat moderate to severe pain.

Sumera Saeed
Jul 30, 2019
Naproxen
A nonsteroidal anti-inflammatory drug (trade name Naprosyn) used in the treatment of arthritis and musculoskeletal inflammation and moderate pain

Sumera Saeed
Jul 30, 2019
FAQs
Can naproxen be taken for headaches?
Yes, naproxen can be effective for tension headaches and migraines.

Sumera Saeed
Oct 28, 2023
Does naproxen raise blood pressure?
Yes, naproxen, like other NSAIDs, can potentially raise blood pressure.

Harlon Moss
Oct 28, 2023
What type of drug is naproxen?
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID).

Sumera Saeed
Oct 28, 2023
Can I buy naproxen without a prescription?
Yes, lower doses of naproxen are available over-the-counter.

Janet White
Oct 28, 2023
Can tramadol cause drowsiness?
Yes, drowsiness is a potential side effect of tramadol.

Aimie Carlson
Oct 28, 2023
Is it safe to drink alcohol with naproxen?
Mixing alcohol with naproxen can increase the risk of stomach bleeding.

Harlon Moss
Oct 28, 2023
Is tramadol safe for long-term use?
Long-term use of tramadol requires monitoring due to risks of dependency and side effects.

Sara Rehman
Oct 28, 2023
Can I become addicted to tramadol?
Yes, there's a potential for misuse and dependency with tramadol.

Sumera Saeed
Oct 28, 2023
Is naproxen safe for kids?
Consult a pediatrician before giving naproxen to children.

Sara Rehman
Oct 28, 2023
How long does the effect of tramadol last?
The duration varies but usually lasts between 4 to 6 hours for immediate-release versions.

Janet White
Oct 28, 2023
What are common uses for naproxen?
Arthritis, menstrual cramps, and headaches are among its uses.

Sumera Saeed
Oct 28, 2023
Is tramadol effective for nerve pain?
Tramadol can be prescribed for various pain types, including neuropathic pain, but consult a doctor.

Aimie Carlson
Oct 28, 2023
Is tramadol an opioid?
Tramadol is an opioid-like pain reliever but is distinct from traditional opioids.

Huma Saeed
Oct 28, 2023
Is tramadol stronger than regular painkillers?
Tramadol is generally stronger than many over-the-counter painkillers.

Aimie Carlson
Oct 28, 2023
Can naproxen cause an upset stomach?
Yes, gastrointestinal issues are common side effects of NSAIDs like naproxen.

Sumera Saeed
Oct 28, 2023
Does tramadol interact with other medications?
Yes, especially with other central nervous system depressants. Always check with a doctor.

Aimie Carlson
Oct 28, 2023
Can I take naproxen if I'm pregnant?
Always consult with a healthcare professional before taking medications during pregnancy.

Aimie Carlson
Oct 28, 2023
What's the risk of overdose with tramadol?
Overdose can result in respiratory depression, which can be life-threatening.

Sumera Saeed
Oct 28, 2023
How often should I take tramadol?
Dosage varies; always follow the prescribing physician's instructions.

Aimie Carlson
Oct 28, 2023
About Author
Written by
Sumera SaeedSumera is an experienced content writer and editor with a niche in comparative analysis. At Diffeence Wiki, she crafts clear and unbiased comparisons to guide readers in making informed decisions. With a dedication to thorough research and quality, Sumera's work stands out in the digital realm. Off the clock, she enjoys reading and exploring diverse cultures.

Edited by
Huma SaeedHuma is a renowned researcher acclaimed for her innovative work in Difference Wiki. Her dedication has led to key breakthroughs, establishing her prominence in academia. Her contributions continually inspire and guide her field.
