Zyrtec vs. Benadryl: What's the Difference?

Edited by Sawaira Riaz || By Sumera Saeed || Updated on October 20, 2023

Zyrtec (cetirizine) and Benadryl (diphenhydramine) are antihistamines, but Zyrtec is a second-generation antihistamine while Benadryl is a first-generation antihistamine.

Key Differences

Zyrtec and Benadryl are both common antihistamine medications, but they belong to different generations. Zyrtec, whose generic name is cetirizine, is categorized as a second-generation antihistamine. This generation is known for its reduced tendency to cause drowsiness compared to its predecessors. On the flip side, Benadryl, with its generic name being diphenhydramine, is a first-generation antihistamine. These antihistamines easily cross the blood-brain barrier, which can often lead to drowsiness in users.

Oct 20, 2023

Another distinction between Zyrtec and Benadryl is their duration of action. While Zyrtec can offer up to 24 hours of relief from symptoms, Benadryl's effects typically last between 4 to 6 hours. This means that individuals using Benadryl might need to take it more frequently than those using Zyrtec. However, due to its sedative effects, Benadryl is sometimes used as a sleep aid in addition to its use for allergy relief.

Oct 20, 2023

Zyrtec's formulation primarily targets allergic reactions and provides consistent relief over an extended period. This makes it a preferred option for many with persistent allergies. In contrast, Benadryl is more than just an allergy medication; its diverse applications include aiding with insomnia, motion sickness, and even symptoms of Parkinson's disease.

Oct 20, 2023

While both Zyrtec and Benadryl are effective in combating allergy symptoms, they each have different side effects and drug interactions. It's always essential for individuals to consult with a healthcare professional to determine which medication is most suitable for their specific needs and conditions.

Oct 20, 2023

Comparison Chart

Generational Category

Second-generation antihistamine

First-generation antihistamine

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Generic Name

Cetirizine

Diphenhydramine

Oct 20, 2023

Duration of Effect

Up to 24 hours

4 to 6 hours

Oct 20, 2023

Common Side Effects

Less likely to cause drowsiness

Often causes drowsiness

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Other Uses

Primarily for allergies

Allergies, sleep aid, motion sickness

Oct 20, 2023

Zyrtec and Benadryl Definitions

Zyrtec

An over-the-counter antihistamine used to treat allergy symptoms.

She took Zyrtec to alleviate her springtime hay fever.

Oct 20, 2023

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Benadryl

A brand-name drug with the active ingredient diphenhydramine.

He found Benadryl effective against his seasonal allergies.

Oct 20, 2023

Zyrtec

A medication often prescribed for perennial allergic rhinitis.

Her doctor recommended Zyrtec for her year-round allergies.

Oct 20, 2023

Benadryl

A medication commonly used for allergies, motion sickness, and sleep aid.

Before their road trip, she packed Benadryl to prevent motion sickness.

Oct 20, 2023

Zyrtec

A popular brand-name drug with the active ingredient cetirizine.

He replaced his generic allergy pills with Zyrtec for consistent relief.

Oct 20, 2023

Benadryl

A versatile medicine also used to treat symptoms of Parkinson's disease.

In addition to allergies, Benadryl can also aid Parkinson's patients.

Oct 20, 2023

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Zyrtec

A non-sedating antihistamine that targets allergic reactions.

For her cat allergies, she always chooses Zyrtec.

Oct 20, 2023

Benadryl

A first-generation antihistamine known to cause drowsiness.

Benadryl helps her sleep when her allergies flare up at night.

Oct 20, 2023

Zyrtec

A second-generation allergy medication known for its long-lasting effects.

Zyrtec provides her with relief throughout the day.

Oct 20, 2023

Benadryl

An over-the-counter antihistamine used to relieve allergic symptoms.

He took Benadryl after a bee sting to prevent severe reactions.

Oct 20, 2023

Benadryl

Antihistamine (trade name Benadryl) used to treat allergic reactions involving the nasal passages (hay fever) and also to treat motion sickness

Aug 01, 2019

FAQs

Is Zyrtec less sedating than Benadryl?

Yes, Zyrtec is less likely to cause drowsiness compared to Benadryl.

Oct 20, 2023

Which lasts longer, Zyrtec or Benadryl?

Zyrtec generally lasts up to 24 hours, while Benadryl lasts 4 to 6 hours.

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What's the generic name for Zyrtec?

The generic name for Zyrtec is cetirizine.

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Can I take Zyrtec and Benadryl together?

It's not typically recommended due to potential side effects. Always consult a healthcare professional.

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Are Zyrtec and Benadryl the same?

No, Zyrtec is a second-generation antihistamine, while Benadryl is a first-generation antihistamine.

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Is Zyrtec safe for daily use?

Zyrtec is typically safe for daily use, but one should consult with a healthcare professional.

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Can I take Zyrtec for skin allergies?

Yes, Zyrtec can be effective against skin allergies like hives.

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Can I use Benadryl as a sleep aid?

Yes, Benadryl's sedative effects make it a common choice for a sleep aid.

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What other uses does Benadryl have besides treating allergies?

Benadryl is also used for insomnia, motion sickness, and symptoms of Parkinson's.

Oct 20, 2023

Can children take Zyrtec?

Yes, but always consult with a healthcare professional for appropriate dosing.

Oct 20, 2023

What type of allergies is Zyrtec most effective against?

Zyrtec effectively treats indoor and outdoor allergies.

Oct 20, 2023

Are there non-drowsy versions of Benadryl?

Traditional Benadryl is known for its sedative effects, but there are other antihistamines available that are non-drowsy.

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How should I store Benadryl?

Benadryl should be stored at room temperature, away from light and moisture.

Oct 20, 2023

How often should I take Benadryl?

Benadryl typically lasts 4 to 6 hours, but always follow dosing recommendations.

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Are there side effects to Zyrtec?

Zyrtec can have side effects, including headache, stomach pain, and dry mouth.

Oct 20, 2023

Is it safe to drive after taking Benadryl?

Due to its sedative effects, one should avoid activities requiring alertness after taking Benadryl.

Oct 20, 2023

How does Zyrtec reduce allergy symptoms?

Zyrtec works by blocking histamine, a substance in the body responsible for allergic reactions.

Oct 20, 2023

What's the difference between children's Benadryl and regular Benadryl?

The primary difference is the dosing amount and sometimes the formulation.

Oct 20, 2023

How soon does Zyrtec start working?

Zyrtec typically starts working within an hour of ingestion.

Oct 20, 2023

What's the primary active ingredient in Benadryl?

The primary active ingredient in Benadryl is diphenhydramine.

Oct 20, 2023

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About Author

Written by

Sumera is an experienced content writer and editor with a niche in comparative analysis. At Diffeence Wiki, she crafts clear and unbiased comparisons to guide readers in making informed decisions. With a dedication to thorough research and quality, Sumera's work stands out in the digital realm. Off the clock, she enjoys reading and exploring diverse cultures.

Edited by

Sawaira is a dedicated content editor at difference.wiki, where she meticulously refines articles to ensure clarity and accuracy. With a keen eye for detail, she upholds the site's commitment to delivering insightful and precise content.