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DNA Polymerase 1 vs. DNA Polymerase 3: What's the Difference?

Edited by Huma Saeed || By Sumera Saeed || Updated on October 30, 2023
DNA polymerase 1 replaces RNA primers with DNA; DNA polymerase 3 synthesizes the leading and lagging DNA strands.

Key Differences

DNA polymerase 1 is an enzyme that plays a crucial role in the process of DNA replication, where it is responsible for replacing RNA primers with DNA nucleotides. In contrast, DNA polymerase 3 is another enzyme that plays a different role in DNA replication, where it is responsible for synthesizing the leading and lagging DNA strands during replication.
Sumera Saeed
Oct 30, 2023
The main function of DNA polymerase 1 is to remove the RNA primers and replace them with DNA nucleotides, ensuring that the newly synthesized DNA strand is entirely composed of DNA. On the other hand, DNA polymerase 3's primary function is to synthesize the new DNA strands by adding DNA nucleotides to the growing DNA chain during replication.
Sumera Saeed
Oct 30, 2023
While both DNA polymerase 1 and DNA polymerase 3 are involved in the process of DNA replication, they have different functions and work at different stages of replication. DNA polymerase 1 acts later in the replication process to replace RNA primers with DNA, while DNA polymerase 3 acts earlier in the process to synthesize the new DNA strands.
Sumera Saeed
Oct 30, 2023
In summary, DNA polymerase 1 and DNA polymerase 3 are both essential enzymes involved in the process of DNA replication, but they have distinct roles. DNA polymerase 1 is responsible for replacing RNA primers with DNA, while DNA polymerase 3 is responsible for synthesizing the leading and lagging DNA strands during replication.
Harlon Moss
Oct 30, 2023

Comparison Chart

Main Function

Replaces RNA primers with DNA
Synthesizes leading and lagging strands
Sumera Saeed
Oct 30, 2023
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Role in DNA Replication

Acts later in the process
Acts earlier in the process
Sumera Saeed
Oct 30, 2023

Type of Strands Affected

Affects newly synthesized DNA strand
Affects leading and lagging strands
Sumera Saeed
Oct 30, 2023

Interaction with Primers

Removes RNA primers
Does not interact directly with primers
Sara Rehman
Oct 30, 2023

Enzyme Activity

5' to 3' polymerase and 5' to 3' exonuclease activity
5' to 3' polymerase activity
Janet White
Oct 30, 2023

DNA Polymerase 1 and DNA Polymerase 3 Definitions

DNA Polymerase 1

DNA polymerase 1 acts later in the process of DNA replication.
After DNA polymerase 3 has synthesized the new DNA strands, DNA polymerase 1 replaces the RNA primers with DNA.
Aimie Carlson
Oct 30, 2023
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DNA Polymerase 3

DNA polymerase 3 acts earlier in the process of DNA replication.
DNA polymerase 3 is one of the first enzymes to act during DNA replication, synthesizing the new DNA strands.
Sumera Saeed
Oct 30, 2023

DNA Polymerase 1

DNA polymerase 1 is essential for DNA replication.
Without DNA polymerase 1, the newly synthesized DNA strand would contain RNA primers, which is not desirable.
Aimie Carlson
Oct 30, 2023

DNA Polymerase 3

DNA polymerase 3 is essential for DNA replication.
Without DNA polymerase 3, the new DNA strands could not be synthesized, and replication would not occur.
Sumera Saeed
Oct 30, 2023

DNA Polymerase 1

DNA polymerase 1 has 5' to 3' polymerase activity.
The 5' to 3' polymerase activity of DNA polymerase 1 adds DNA nucleotides to the growing DNA chain.
Sumera Saeed
Oct 30, 2023

DNA Polymerase 3

DNA polymerase 3 is a highly processive enzyme.
The high processivity of DNA polymerase 3 allows it to synthesize long stretches of DNA without dissociating from the template strand.
Sumera Saeed
Oct 30, 2023

DNA Polymerase 1

DNA polymerase 1 is an enzyme that replaces RNA primers with DNA nucleotides.
DNA polymerase 1 ensures that the newly synthesized DNA strand is entirely composed of DNA.
Huma Saeed
Oct 30, 2023

DNA Polymerase 3

DNA polymerase 3 has 5' to 3' polymerase activity.
The 5' to 3' polymerase activity of DNA polymerase 3 is essential for synthesizing the new DNA strands.
Sumera Saeed
Oct 30, 2023

DNA Polymerase 1

DNA polymerase 1 has 5' to 3' exonuclease activity.
The 5' to 3' exonuclease activity of DNA polymerase 1 removes the RNA primers.
Sumera Saeed
Oct 30, 2023

DNA Polymerase 3

DNA polymerase 3 is an enzyme that synthesizes the leading and lagging strands of DNA during replication.
DNA polymerase 3 adds DNA nucleotides to the growing DNA chain during replication.
Huma Saeed
Oct 30, 2023

FAQs

What is DNA polymerase 3?

DNA polymerase 3 is an enzyme that synthesizes the leading and lagging strands of DNA during replication.
Huma Saeed
Oct 30, 2023

Does DNA polymerase 1 have exonuclease activity?

Yes, DNA polymerase 1 has 5' to 3' exonuclease activity.
Sumera Saeed
Oct 30, 2023

What is the main function of DNA polymerase 1?

The main function of DNA polymerase 1 is to replace RNA primers with DNA.
Sumera Saeed
Oct 30, 2023

What is the role of DNA polymerase 3 in DNA replication?

DNA polymerase 3 acts earlier in the process of DNA replication to synthesize the leading and lagging strands.
Sumera Saeed
Oct 30, 2023

What type of activity does DNA polymerase 3 have?

DNA polymerase 3 has 5' to 3' polymerase activity.
Sara Rehman
Oct 30, 2023

Does DNA polymerase 3 have exonuclease activity?

No, DNA polymerase 3 does not have exonuclease activity.
Sumera Saeed
Oct 30, 2023

What is the difference between DNA polymerase 1 and DNA polymerase 3?

The main difference is that DNA polymerase 1 replaces RNA primers with DNA, while DNA polymerase 3 synthesizes the new strands.
Harlon Moss
Oct 30, 2023

What is the main function of DNA polymerase 3?

The main function of DNA polymerase 3 is to synthesize the leading and lagging strands of DNA.
Sara Rehman
Oct 30, 2023

How does DNA polymerase 3 interact with primers?

DNA polymerase 3 does not interact directly with primers.
Sumera Saeed
Oct 30, 2023

Does DNA polymerase 3 act on the leading or lagging strand?

DNA polymerase 3 acts on both the leading and lagging strands during replication.
Sara Rehman
Oct 30, 2023

Is DNA polymerase 1 essential for DNA replication?

Yes, DNA polymerase 1 is essential for DNA replication.
Harlon Moss
Oct 30, 2023

What type of activity does DNA polymerase 1 have?

DNA polymerase 1 has 5' to 3' polymerase and 5' to 3' exonuclease activity.
Janet White
Oct 30, 2023

How does DNA polymerase 1 interact with primers?

DNA polymerase 1 removes RNA primers during DNA replication.
Sumera Saeed
Oct 30, 2023

Does DNA polymerase 1 act on the leading or lagging strand?

DNA polymerase 1 acts on both the leading and lagging strands to replace RNA primers with DNA.
Sumera Saeed
Oct 30, 2023

What are some common misconceptions about DNA polymerase 1?

A common misconception is that DNA polymerase 1 is not as important as DNA polymerase 3, but it is essential for replication.
Sumera Saeed
Oct 30, 2023

What are some common misconceptions about DNA polymerase 3?

A common misconception is that DNA polymerase 3 is the only enzyme involved in DNA replication.
Sumera Saeed
Oct 30, 2023

How are DNA polymerase 1 and DNA polymerase 3 similar?

Both are essential enzymes involved in DNA replication.
Sara Rehman
Oct 30, 2023

What is the role of DNA polymerase 1 in DNA replication?

DNA polymerase 1 acts later in the process of DNA replication to replace RNA primers with DNA.
Janet White
Oct 30, 2023

What is DNA polymerase 1?

DNA polymerase 1 is an enzyme that replaces RNA primers with DNA nucleotides during DNA replication.
Sumera Saeed
Oct 30, 2023

Is DNA polymerase 3 essential for DNA replication?

Yes, DNA polymerase 3 is essential for DNA replication.
Janet White
Oct 30, 2023
About Author
Written by
Sumera Saeed
Sumera is an experienced content writer and editor with a niche in comparative analysis. At Diffeence Wiki, she crafts clear and unbiased comparisons to guide readers in making informed decisions. With a dedication to thorough research and quality, Sumera's work stands out in the digital realm. Off the clock, she enjoys reading and exploring diverse cultures.
Edited by
Huma Saeed
Huma is a renowned researcher acclaimed for her innovative work in Difference Wiki. Her dedication has led to key breakthroughs, establishing her prominence in academia. Her contributions continually inspire and guide her field.

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