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Cetirizine Hydrochloride vs. Cetirizine Dihydrochloride: What's the Difference?

Edited by Janet White || By Harlon Moss || Published on December 3, 2023
Cetirizine hydrochloride and cetirizine dihydrochloride are two salt forms of cetirizine, differing mainly in their chemical composition.

Key Differences

Cetirizine hydrochloride is a salt form of cetirizine, an antihistamine used to treat allergy symptoms. Cetirizine dihydrochloride, also an antihistamine, is a different salt form of the same active ingredient, cetirizine.
Both cetirizine hydrochloride and cetirizine dihydrochloride are effective in relieving symptoms such as sneezing, itching, and runny nose. However, their chemical structure differs slightly due to the presence of one (hydrochloride) versus two (dihydrochloride) chloride ions.
Cetirizine hydrochloride is commonly found in various allergy medications and is widely used. Cetirizine dihydrochloride, while similar in effect, may be found in different formulations or brands.
The efficacy of cetirizine hydrochloride and cetirizine dihydrochloride in treating allergic reactions is generally comparable. The choice between the two may depend on availability, brand preference, or specific formulations.
Both forms are typically administered orally and have similar side effects, such as drowsiness or dry mouth, but individual response can vary slightly due to the different salt forms.

Comparison Chart

Chemical Composition

Contains one chloride ion
Contains two chloride ions

Common Availability

Widely used in many allergy medications
Available in specific formulations or brands


Effective for allergy symptoms
Similarly effective for allergy symptoms


Found in various branded and generic medications
May differ in certain brands or formulations

Side Effects

Similar side effects like drowsiness
Comparable side effects, individual variations

Cetirizine Hydrochloride and Cetirizine Dihydrochloride Definitions

Cetirizine Hydrochloride

Often used in generic and branded allergy medications.
I prefer the generic version of cetirizine hydrochloride for cost-effectiveness.

Cetirizine Dihydrochloride

Similar in function to cetirizine hydrochloride but with a slightly different chemical structure.
The doctor prescribed cetirizine dihydrochloride for my allergic rhinitis.

Cetirizine Hydrochloride

Known for its antihistamine properties with minimal sedative effects.
Cetirizine hydrochloride is less likely to cause drowsiness compared to other antihistamines.

Cetirizine Dihydrochloride

Available in certain brands or formulations distinct from cetirizine hydrochloride.
This specific brand uses cetirizine dihydrochloride in its allergy medication.

Cetirizine Hydrochloride

Effective in reducing symptoms of allergic rhinitis and urticaria.
Cetirizine hydrochloride helped relieve his symptoms of hives.

Cetirizine Dihydrochloride

A safe and effective treatment for chronic urticaria and seasonal allergies.
For chronic hives, cetirizine dihydrochloride can be a good treatment option.

Cetirizine Hydrochloride

An antihistamine used to treat allergy symptoms like sneezing and itching.
She took cetirizine hydrochloride for her seasonal allergies.

Cetirizine Dihydrochloride

An antihistamine variant used for treating allergies, with two chloride ions.
Cetirizine dihydrochloride is effective for my pet allergies.

Cetirizine Hydrochloride

A widely available medication for allergic reactions and hay fever.
Cetirizine hydrochloride is a common ingredient in over-the-counter allergy pills.

Cetirizine Dihydrochloride

Provides relief from sneezing, watery eyes, and runny nose due to allergies.
After taking cetirizine dihydrochloride, her hay fever symptoms improved.


Is cetirizine hydrochloride available over-the-counter?

Yes, it's commonly found in OTC allergy medications.

What is cetirizine hydrochloride?

An antihistamine used for treating allergy symptoms.

How quickly does cetirizine hydrochloride work?

It usually starts working within an hour of ingestion.

What is cetirizine dihydrochloride?

A salt form of cetirizine, an antihistamine for allergies.

Can both forms cause drowsiness?

Yes, but they are generally less sedating than older antihistamines.

Can cetirizine dihydrochloride treat all types of allergies?

It's effective for common allergies, but efficacy may vary.

Is cetirizine dihydrochloride safe for pregnant women?

It's best to consult a doctor before using during pregnancy.

Does cetirizine dihydrochloride interact with other medications?

It can, so it's important to check with a healthcare provider.

Can cetirizine hydrochloride be taken with food?

Yes, it can be taken with or without food.

Can cetirizine hydrochloride be used for children?

Yes, but dosage should be adjusted for age and weight.

Are cetirizine hydrochloride and dihydrochloride equally effective?

Yes, both are effective in treating allergy symptoms.

Are the side effects of cetirizine dihydrochloride significant?

Side effects are usually mild, like dry mouth or drowsiness.

Is cetirizine hydrochloride suitable for daily use?

Yes, it can be used daily for chronic allergies.

Can I drive after taking cetirizine hydrochloride?

Caution is advised as it can cause drowsiness in some individuals.

Is cetirizine dihydrochloride a prescription drug?

It depends on the formulation and country regulations.

Is cetirizine dihydrochloride alcohol-free?

Yes, the medication itself does not contain alcohol.

Is cetirizine dihydrochloride effective for skin allergies?

Yes, it can be used to treat skin allergies like urticaria.

Does cetirizine dihydrochloride cause dry mouth?

Dry mouth is a possible side effect but not very common.

How long can one take cetirizine hydrochloride?

It's generally safe for long-term use, but consult a doctor for extended use.

Can cetirizine hydrochloride be used for pet allergies?

Yes, it's effective for pet allergies.
About Author
Written by
Harlon Moss
Harlon is a seasoned quality moderator and accomplished content writer for Difference Wiki. An alumnus of the prestigious University of California, he earned his degree in Computer Science. Leveraging his academic background, Harlon brings a meticulous and informed perspective to his work, ensuring content accuracy and excellence.
Edited by
Janet White
Janet White has been an esteemed writer and blogger for Difference Wiki. Holding a Master's degree in Science and Medical Journalism from the prestigious Boston University, she has consistently demonstrated her expertise and passion for her field. When she's not immersed in her work, Janet relishes her time exercising, delving into a good book, and cherishing moments with friends and family.

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