Difference Wiki

Duloxetine vs. Fluoxetine: What's the Difference?

Edited by Sawaira Riaz || By Sara Rehman || Published on January 13, 2024
Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) for depression, anxiety, and pain, while fluoxetine is a selective serotonin reuptake inhibitor (SSRI) mainly for depression and OCD.

Key Differences

Duloxetine, an SNRI, is used to treat major depressive disorder, general anxiety disorder, and chronic pain conditions. Fluoxetine, an SSRI, is primarily used for treating depression, obsessive-compulsive disorder, and panic attacks.
Sara Rehman
Jan 13, 2024
Duloxetine works by balancing serotonin and norepinephrine in the brain, helping alleviate pain and mood symptoms. Fluoxetine targets serotonin levels in the brain, aiding in mood improvement and anxiety reduction.
Sara Rehman
Jan 13, 2024
The side effects of duloxetine can include nausea, dry mouth, and dizziness. Fluoxetine's side effects often include sleep disturbances, sexual dysfunction, and nervousness.
Sara Rehman
Jan 13, 2024
Duloxetine is also prescribed for diabetic neuropathy and fibromyalgia pain management. Fluoxetine is additionally used for treating bulimia nervosa and premenstrual dysphoric disorder.
Sawaira Riaz
Jan 13, 2024
Both medications require careful dosage adjustment and monitoring, especially when starting or changing doses. Discontinuation of either duloxetine or fluoxetine should be gradual to prevent withdrawal symptoms.
Sara Rehman
Jan 13, 2024
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Comparison Chart

Class of Drug

Serotonin-norepinephrine reuptake inhibitor (SNRI).
Selective serotonin reuptake inhibitor (SSRI).
Sara Rehman
Jan 13, 2024

Primary Uses

Depression, anxiety, chronic pain.
Depression, OCD, panic disorder.
Sawaira Riaz
Jan 13, 2024

Side Effects

Nausea, dry mouth, dizziness.
Sleep disturbances, sexual dysfunction.
Sara Rehman
Jan 13, 2024

Additional Uses

Diabetic neuropathy, fibromyalgia.
Bulimia nervosa, premenstrual dysphoric disorder.
Harlon Moss
Jan 13, 2024

Withdrawal Management

Gradual dose reduction recommended.
Gradual discontinuation to avoid withdrawal symptoms.
Aimie Carlson
Jan 13, 2024
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Duloxetine and Fluoxetine Definitions

Duloxetine

A drug used for chronic pain relief.
Duloxetine helped alleviate his diabetic neuropathy pain.
Sara Rehman
Dec 22, 2023

Fluoxetine

An SSRI for mood disorders.
Fluoxetine regulates serotonin levels in the brain.
Aimie Carlson
Dec 22, 2023

Duloxetine

An SNRI affecting brain chemicals.
Duloxetine balances serotonin and norepinephrine.
Aimie Carlson
Dec 22, 2023

Fluoxetine

A medication for treating depression.
Fluoxetine was effective in managing his depression.
Sawaira Riaz
Dec 22, 2023

Duloxetine

An antidepressant medication.
Duloxetine was prescribed to her for depression.
Sara Rehman
Dec 22, 2023

Fluoxetine

A treatment for panic attacks.
Fluoxetine helped reduce the frequency of his panic attacks.
Sara Rehman
Dec 22, 2023

Duloxetine

Used in fibromyalgia management.
Duloxetine is part of her fibromyalgia treatment plan.
Harlon Moss
Dec 22, 2023

Fluoxetine

Used for obsessive-compulsive disorder.
Her OCD symptoms lessened with fluoxetine.
Sara Rehman
Dec 22, 2023

Duloxetine

A treatment for anxiety disorders.
Her anxiety symptoms improved with duloxetine.
Aimie Carlson
Dec 22, 2023

Fluoxetine

Prescribed for bulimia nervosa.
Fluoxetine is part of her treatment for bulimia.
Janet White
Dec 22, 2023

Duloxetine

A drug of the SNRI class, C18H19NOS, used in its hydrochloride form to treat depression, anxiety, fibromyalgia, and diabetic neuropathy.
Sara Rehman
Dec 20, 2023

Fluoxetine

A drug of the SSRI class, C17H18F3NO, used in its hydrochloride form to treat depression, obsessive-compulsive disorder, panic disorder, premenstrual dysphoric disorder, and certain eating disorders.
Sara Rehman
Dec 20, 2023

Duloxetine

(pharmaceutical drug) A drug that functions as an SNRI and is administered orally in the form of its hydrochloride C18H19NOS·HCl especially to treat depression, anxiety, and chronic pain (such as that associated with fibromyalgia and peripheral neuropathy). It is marketed under the trademark Cymbalta.
Sara Rehman
Dec 20, 2023

Fluoxetine

(pharmaceutical drug) A synthetic compound which inhibits the uptake of serotonin in the brain and is taken to treat depression.
Sara Rehman
Dec 20, 2023

Fluoxetine

A selective-serotonin reuptake inhibitor commonly prescribed as an antidepressant (trade name Prozac)
Sara Rehman
Dec 20, 2023

FAQs

Are there common side effects of duloxetine?

Yes, like nausea and dry mouth.
Sara Rehman
Jan 13, 2024

Is duloxetine safe for everyone?

It requires a doctor's assessment, as it's not suitable for everyone.
Sara Rehman
Jan 13, 2024

Are there side effects to fluoxetine?

Yes, including sleep disturbances and sexual dysfunction.
Sara Rehman
Jan 13, 2024

What is duloxetine used for?

Treating depression, anxiety, and chronic pain.
Sara Rehman
Jan 13, 2024

Can duloxetine treat fibromyalgia?

Yes, it's often prescribed for this condition.
Aimie Carlson
Jan 13, 2024

How does fluoxetine function?

By increasing serotonin levels in the brain.
Aimie Carlson
Jan 13, 2024

Is fluoxetine safe for long-term use?

It can be, under medical supervision.
Harlon Moss
Jan 13, 2024

How long does it take for fluoxetine to work?

Effects can be seen in 4-6 weeks.
Aimie Carlson
Jan 13, 2024

Can fluoxetine help with eating disorders?

Yes, it's used for treating bulimia nervosa.
Sara Rehman
Jan 13, 2024

How does duloxetine work?

It balances serotonin and norepinephrine in the brain.
Sawaira Riaz
Jan 13, 2024

What does fluoxetine treat?

Depression, OCD, and panic disorder.
Janet White
Jan 13, 2024

Is duloxetine addictive?

No, but it should be used as prescribed.
Sara Rehman
Jan 13, 2024

Can duloxetine and fluoxetine be taken together?

Only under a doctor's advice.
Janet White
Jan 13, 2024

Is alcohol safe with duloxetine?

Alcohol can increase certain side effects.
Aimie Carlson
Jan 13, 2024

Can fluoxetine affect sleep?

Yes, it can cause sleep disturbances.
Aimie Carlson
Jan 13, 2024

Can fluoxetine be used in children?

Yes, but under strict medical guidance.
Harlon Moss
Jan 13, 2024

How is duloxetine dosed?

It varies, based on the condition and patient.
Sara Rehman
Jan 13, 2024

Can fluoxetine cause weight changes?

Yes, it can cause weight loss or gain.
Sara Rehman
Jan 13, 2024

Does duloxetine cause withdrawal symptoms?

Yes, if stopped abruptly.
Aimie Carlson
Jan 13, 2024

Are duloxetine and fluoxetine safe during pregnancy?

They require a doctor's evaluation for use during pregnancy.
Sara Rehman
Jan 13, 2024
About Author
Written by
Sara Rehman
Sara Rehman is a seasoned writer and editor with extensive experience at Difference Wiki. Holding a Master's degree in Information Technology, she combines her academic prowess with her passion for writing to deliver insightful and well-researched content.
Edited by
Sawaira Riaz
Sawaira is a dedicated content editor at difference.wiki, where she meticulously refines articles to ensure clarity and accuracy. With a keen eye for detail, she upholds the site's commitment to delivering insightful and precise content.

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