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NADH vs. NADPH: What's the Difference?

Edited by Huma Saeed || By Sumera Saeed || Updated on October 27, 2023
NADH is a coenzyme involved in cellular respiration and energy production; NADPH is crucial for biosynthesis and antioxidant defense.

Key Differences

NADH stands for nicotinamide adenine dinucleotide (NAD) + hydrogen (H). It plays a pivotal role in cellular respiration, particularly in the electron transport chain where it donates electrons.
Sumera Saeed
Oct 27, 2023
NADPH, which stands for nicotinamide adenine dinucleotide phosphate (NADP) + hydrogen (H), is vital in biosynthetic reactions, such as fatty acid and nucleotide synthesis. It also has a key role in antioxidant defense.
Sumera Saeed
Oct 27, 2023
Both NADH and NADPH are forms of the coenzyme NAD. NADH is predominantly involved in catabolic reactions, where it acts as an electron carrier and helps in generating ATP.
Sumera Saeed
Oct 27, 2023
NADPH, on the other hand, is primarily involved in anabolic reactions. It provides the reducing power needed for the synthesis of biomolecules.
Janet White
Oct 27, 2023
Despite their similarities, NADH and NADPH have different roles. NADH is central to energy production, while NADPH is crucial for building and maintaining cells and protecting them from oxidative damage.
Sumera Saeed
Oct 27, 2023
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Comparison Chart

Full Name

Nicotinamide Adenine Dinucleotide + Hydrogen
Nicotinamide Adenine Dinucleotide Phosphate + Hydrogen
Sumera Saeed
Oct 27, 2023

Main Function

Electron carrier in energy production
Provides reducing power for biosynthesis
Sumera Saeed
Oct 27, 2023

Role in Metabolism

Involved in catabolic reactions
Involved in anabolic reactions
Sumera Saeed
Oct 27, 2023

Location in Cells

Mitochondria (in eukaryotes)
Cytoplasm
Janet White
Oct 27, 2023

Electron Donor For

Electron transport chain
Biosynthetic reactions, antioxidant defense
Sara Rehman
Oct 27, 2023
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NADH and NADPH Definitions

NADH

NADH is crucial for ATP synthesis.
Cellular energy production relies heavily on NADH.
Huma Saeed
Oct 27, 2023

NADPH

NADPH stores energy in chemical bonds.
NADPH stores energy for anabolic reactions.
Sara Rehman
Oct 27, 2023

NADH

NADH carries electrons in cellular respiration.
NADH donates electrons to the electron transport chain.
Sumera Saeed
Oct 27, 2023

NADPH

NADPH helps in detoxifying reactive oxygen species.
NADPH is crucial in the regeneration of glutathione.
Sumera Saeed
Oct 27, 2023

NADH

NADH is involved in metabolism.
Various metabolic pathways generate NADH.
Sumera Saeed
Oct 27, 2023

NADPH

NADPH is essential for synthesizing fatty acids and nucleotides.
NADPH provides reducing power for biosynthesis.
Huma Saeed
Oct 27, 2023

NADH

NADH participates in redox reactions.
NADH gets oxidized during the production of ATP.
Sara Rehman
Oct 27, 2023

NADPH

NADPH participates in reduction reactions.
NADPH is reduced during fatty acid synthesis.
Aimie Carlson
Oct 27, 2023

NADH

NADH plays a role in breaking down glucose.
NADH is a byproduct of glycolysis and the Krebs cycle.
Harlon Moss
Oct 27, 2023

NADPH

NADPH is produced in the light reactions of photosynthesis.
In plants, NADPH is generated in the chloroplasts.
Harlon Moss
Oct 27, 2023

NADH

The reduced form of NAD.
Sumera Saeed
Jul 27, 2020

NADPH

The reduced form of NADP.
Sumera Saeed
Jul 27, 2020

FAQs

What does NADH stand for?

NADH stands for Nicotinamide Adenine Dinucleotide + Hydrogen.
Sumera Saeed
Oct 27, 2023

What is the primary role of NADPH?

NADPH provides reducing power for biosynthesis and antioxidant defense.
Aimie Carlson
Oct 27, 2023

Does NADPH participate in anabolic or catabolic processes?

NADPH participates in anabolic processes.
Sumera Saeed
Oct 27, 2023

Where is NADH mainly found in cells?

NADH is mainly found in mitochondria in eukaryotic cells.
Janet White
Oct 27, 2023

Is NADPH involved in energy production?

NADPH is not directly involved in ATP synthesis but provides energy for biosynthetic reactions.
Sumera Saeed
Oct 27, 2023

How is NADH produced?

NADH is produced in glycolysis, the Krebs cycle, and other metabolic pathways.
Janet White
Oct 27, 2023

Where does NADPH function in cells?

NADPH functions in the cytoplasm.
Harlon Moss
Oct 27, 2023

What happens to NADH during cellular respiration?

During cellular respiration, NADH is oxidized to NAD+ in the electron transport chain.
Sara Rehman
Oct 27, 2023

Are NADH and NADPH interchangeable in metabolic processes?

No, NADH and NADPH are not interchangeable; they have specific roles in different metabolic processes.
Sumera Saeed
Oct 27, 2023

What does NADPH stand for?

NADPH stands for Nicotinamide Adenine Dinucleotide Phosphate + Hydrogen.
Huma Saeed
Oct 27, 2023

What is the main function of NADH?

The main function of NADH is to carry electrons for ATP production.
Sumera Saeed
Oct 27, 2023

Is NADH involved in anabolic or catabolic reactions?

NADH is involved in catabolic reactions.
Sara Rehman
Oct 27, 2023

How is NADPH generated?

NADPH is generated in the pentose phosphate pathway and in photosynthesis in plants.
Janet White
Oct 27, 2023

Does NADH play a role in antioxidant defense?

NADH is not directly involved in antioxidant defense; that's more the role of NADPH.
Janet White
Oct 27, 2023

Can NADPH be used in the electron transport chain?

NADPH is not used in the electron transport chain; that's the role of NADH.
Sara Rehman
Oct 27, 2023

Is NADH found in chloroplasts?

NADH is not typically found in chloroplasts; it's mainly in mitochondria.
Sumera Saeed
Oct 27, 2023

What is the importance of NADPH in photosynthesis?

In photosynthesis, NADPH provides reducing power for the synthesis of glucose.
Aimie Carlson
Oct 27, 2023

Can NADH be used for biosynthesis?

NADH is primarily used in energy production, not biosynthesis.
Aimie Carlson
Oct 27, 2023

Is NADPH involved in detoxifying cells?

Yes, NADPH plays a crucial role in detoxifying cells by maintaining antioxidant systems.
Sumera Saeed
Oct 27, 2023

Can NADH be converted to NADPH?

NADH and NADPH are not directly interconvertible; they serve different functions.
Harlon Moss
Oct 27, 2023
About Author
Written by
Sumera Saeed
Sumera is an experienced content writer and editor with a niche in comparative analysis. At Diffeence Wiki, she crafts clear and unbiased comparisons to guide readers in making informed decisions. With a dedication to thorough research and quality, Sumera's work stands out in the digital realm. Off the clock, she enjoys reading and exploring diverse cultures.
Edited by
Huma Saeed
Huma is a renowned researcher acclaimed for her innovative work in Difference Wiki. Her dedication has led to key breakthroughs, establishing her prominence in academia. Her contributions continually inspire and guide her field.

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