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Magnesium Glycinate vs. Magnesium Bisglycinate: What's the Difference?

Edited by Aimie Carlson || By Janet White || Published on December 3, 2023
Magnesium glycinate and magnesium bisglycinate are often used interchangeably, both being forms of magnesium bound to the amino acid glycine, known for high bioavailability and gentle effects on the stomach.

Key Differences

Magnesium glycinate is a compound where magnesium is bound to glycine. Magnesium bisglycinate is essentially the same, with "bis" indicating two glycine molecules, but in practical usage, they are often considered identical.
Both magnesium glycinate and magnesium bisglycinate are highly bioavailable, meaning the body easily absorbs the magnesium from these compounds.
Both forms are known for being gentle on the stomach, making them preferred choices for people with sensitive digestive systems.
They are both used for similar health benefits, including supporting muscle and nerve function, and promoting relaxation and better sleep.
In supplements, magnesium glycinate and magnesium bisglycinate might be labeled interchangeably due to their similar composition and effects.

Comparison Chart

Chemical Structure

Magnesium bound to glycine
Magnesium bound to two glycine molecules



Gastrointestinal Impact

Gentle on the stomach
Gentle on the stomach

Health Benefits

Muscle, nerve support; relaxation
Muscle, nerve support; relaxation

Labeling in Supplements

Often used interchangeably with bisglycinate
Often used interchangeably with glycinate

Magnesium Glycinate and Magnesium Bisglycinate Definitions

Magnesium Glycinate

A magnesium supplement bound to the amino acid glycine.
Magnesium glycinate is recommended for its high absorption and minimal gastrointestinal side effects.

Magnesium Bisglycinate

Beneficial for muscle relaxation and nerve health.
Magnesium bisglycinate can be effective in managing muscle stiffness.

Magnesium Glycinate

A preferred magnesium supplement for its gentle effects on the stomach.
Doctors often suggest magnesium glycinate for patients with sensitive digestion.

Magnesium Bisglycinate

A form of magnesium bound to two molecules of the amino acid glycine.
Magnesium bisglycinate is often selected for its enhanced absorption.

Magnesium Glycinate

Used to improve magnesium levels in the body.
After experiencing leg cramps, she started taking magnesium glycinate.

Magnesium Bisglycinate

Used for similar purposes as magnesium glycinate, like improving magnesium levels.
She switched to magnesium bisglycinate for better magnesium supplementation.

Magnesium Glycinate

Known for supporting muscle and nerve function.
Athletes often use magnesium glycinate for muscle recovery.

Magnesium Bisglycinate

Aids in relaxation and may improve sleep patterns.
Many find magnesium bisglycinate helpful in achieving more restful sleep.

Magnesium Glycinate

Helps in promoting relaxation and better sleep.
He found that magnesium glycinate improved his sleep quality.

Magnesium Bisglycinate

Known for being easy on the digestive system.
For those with gastrointestinal issues, magnesium bisglycinate is a suitable option.


Is magnesium bisglycinate good for sleep?

Yes, it's often used to promote relaxation and improve sleep quality.

Can magnesium glycinate cause stomach issues?

It's generally gentle on the stomach compared to other forms of magnesium.

Is magnesium bisglycinate better absorbed than other forms?

Yes, it's highly bioavailable, meaning it's well absorbed.

Is magnesium glycinate suitable for daily use?

Yes, when taken as directed, it's suitable for daily supplementation.

Are magnesium glycinate and bisglycinate the same?

They are very similar and often used interchangeably in supplements.

Can magnesium bisglycinate help with stress?

Yes, it's known for its calming effects and can aid in stress management.

How does magnesium glycinate affect muscle function?

It supports muscle relaxation and can help in reducing cramps.

Does magnesium glycinate aid in bone health?

Magnesium plays a role in bone health, so it can be beneficial as part of a balanced diet.

Can magnesium glycinate improve heart health?

Magnesium is important for heart health, but specific effects depend on individual health conditions.

What is magnesium glycinate used for?

It's used for magnesium supplementation, muscle and nerve support, and relaxation.

Can magnesium glycinate help with anxiety?

It may have calming effects, but it's not a substitute for professional medical treatment for anxiety.

How much magnesium glycinate should one take?

Dosage varies based on individual needs; it's best to follow label directions or a healthcare provider's advice.

Can children take magnesium bisglycinate?

It's advisable to consult a pediatrician before giving any supplements to children.

Does magnesium bisglycinate interact with medications?

It can interact with certain medications, so it's best to consult a healthcare provider.

Are there any side effects of magnesium bisglycinate?

It's generally well-tolerated, but high doses can lead to digestive issues.

Can magnesium glycinate cause drowsiness?

It may promote relaxation, but it shouldn't cause significant drowsiness.

Is magnesium bisglycinate natural?

It's a synthesized compound, but the magnesium and glycine are naturally occurring elements.

Can magnesium glycinate be taken with food?

Yes, it can be taken with or without food, though some may find it gentler on the stomach when taken with meals.

Is magnesium bisglycinate vegan-friendly?

Many magnesium bisglycinate supplements are vegan, but it's important to check the label.

Does magnesium bisglycinate aid digestion?

While it's gentle on the stomach, its primary role isn't in aiding digestion.
About Author
Written by
Janet White
Janet White has been an esteemed writer and blogger for Difference Wiki. Holding a Master's degree in Science and Medical Journalism from the prestigious Boston University, she has consistently demonstrated her expertise and passion for her field. When she's not immersed in her work, Janet relishes her time exercising, delving into a good book, and cherishing moments with friends and family.
Edited by
Aimie Carlson
Aimie Carlson, holding a master's degree in English literature, is a fervent English language enthusiast. She lends her writing talents to Difference Wiki, a prominent website that specializes in comparisons, offering readers insightful analyses that both captivate and inform.

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