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Difference Between Bactericidal and Bacteriostatic

Main Difference

The main difference between Bactericidal and Bacteriostatic is that the Bactericidal is the type of antibiotic that kills the bacteria, whereas the Bacteriostatic is the type of antibiotic that prevents the further growth of the bacteria.

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Bactericidal vs. Bacteriostatic

Bactericidal destroys the bacteria; on the other hand, bacteriostatic inhibits the growth of bacteria. The work of bactericidal is irreversible; on the flip side, the work of bacteriostatic is reversible. Bactericidal causes a decrease in several bacterial cells; on the other hand, bacteriostatic does not cause a decrease in the number of bacterial cells.

Bactericidal antibiotics disrupt the bacterial cell wall; on the other hand, bacteriostatic causes the inhibition of growth of bacteria by preventing DNA replication and other metabolic activities. Bactericidal may cause toxic shock syndromes; on the flip side, bacteriostatic has no little side effects. Bactericidal does not work with the immune system of the host; on the other hand, bacteriostatic causes the immune system of the host to prevent the growth of the bacterial cells.

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Bactericidal mainly use in diseases like meningitis and endocarditis; on the flip side, bacteriostatic usually use in diseases of the urinary tract and gangrene wound infections. The examples of bactericidal are penicillin, vancomycin, monoglycosidic antibiotics, whereas the examples of bacteriostatic are streptomycin, tetracycline, chloramphenicol.

Comparison Chart

BactericidalBacteriostatic
Bactericidal refers to the destruction of the bacterial cellBacteriostatic refers to the inhibition of the bacterial cell
Action
Its action is irreversibleIts action is reversible
Working
It works by interacting with the cell wall of the bacterial cellIt works by causing the prevention of DNA replication and protein synthesis
Immune System of Host
It does not work with the immune system of the hostIt works with the immune system of the host
Side Effects
Causes the toxic shock syndromeHave little or no side effect
Amount of Doses
A little dose can cause its effectOnly a high dose has its effect
Specificity
It is specific for only diseases like endocarditis and meningitis, etcIt is specific for urinary infections, and gangrene wound infections, etc
Examples
It includes Penicillin derivatives, vancomycin, monoglycosidic antibiotics, etcIt includes Tetracycline, spectinomycin, sulfonamides, etc
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What is Bactericidal?

Bactericidal is the special type of antibiotic that works by killing the bacterial cells. As it involves the destruction of bacterial cells, it causes a decrease in the number of bacterial cells. That’s why the function of bactericidal antibiotics is not reversible. It destroys bacterial cells.

This destruction of bacterial cells causes toxic shock syndromes in the host cell. It usually does not work with the immune system of the host cell. This antibiotic is useful even in its little amount. The concentration of the bactericidal antibiotic drug to kill the bacterial cell is express in the MBC term. This type of drug is specific for some diseases like meningitis, etc.

It destroys bacterial cells by interfering and penetrating the cell wall of bacteria. This type of drug has a little preference because of its side effects, and bacteriostatic more commonly used in this process. Bactericidal contributes or causes the irreversible death of bacterial cells. It not only affects the cell wall of bacteria but also interacts with the proteins, lipids, carbohydrates, and enzymes of bacterial cells.

Bactericidal does not cause any other effects on bacterial cells rather than the direct treatment of bacterial cell death. The examples of bactericidal include derivatives of the penicillin, vancomycin, and monoglycosidic antibiotics.

What is Bacteriostatic?

Bacteriostatic is a special type of antibiotic that deals with the inhibition of bacterial cell growth. As it is only involved in the prevention of bacterial cell growth, it does not cause a decrease in the number of individual bacterial cells. That’s why the function of bacteriostatic is reversible. It does not destroy the cell.

This type of antibiotic has little or no side effects in the host cells. It completes its work by working with the immune system of the host cells. Bacteriostatic drugs are useful in the function when there is a large number of drugs used. The concentration of bacteriostatic drugs to stop the growth of bacterial cells is expressed in the MIC term.

It is specific for urinary tract infections and gangrene wound infections. It performs its function by preventing DNA replication and protein synthesis. Bacteriostatic because of its little side effects are more commonly used. It causes reversible actions that can get to its normal functions after the conditions removed.

It not only prevents the growth of bacterial cells but also causes the prevention of the reproduction of the bacterial cells. It used to prevent the bacterial cells from dividing into daughter cells by binary fission. The most common examples of bacteriostatic drugs are tetracycline, spectinomycin, chloramphenicol, and sulfonamides, etc.

Key Differences

  1. Bactericidal works for the destruction of bacterial cells, whereas the Bacteriostatic works for the growth prevention of bacterial cells.
  2. The action of Bactericidal is not reversible; on the other hand, the action of Bacteriostatic is reversible.
  3. Bactericidal does not work with the immune system of the host; on the flip side, Bacteriostatic works with the immune system of the host.
  4. Bactericidal causes toxic shock syndrome; Bacteriostatic has a little or no toxic effect.
  5. Bactericidal antibiotics mainly work by interfering with the cell wall of bacterial cells; on the other hand, Bacteriostatic works by inhibiting DNA replication and protein synthesis.
  6. Bactericidal causes a decrease in the number of bacterial cells; on the flip side, Bacteriostatic does not cause a decrease in the number of bacterial cells.
  7. Bactericidal can perform its function by a little number of doses; on the other hand, Bacteriostatic can perform its function only with its high amount of doses.
  8. Bactericidal is specific only for diseases like endocarditis, and meningitis; on the flip side, Bacteriostatic is specific for the urinary tract infections and gangrene wound infections.
  9. The examples of bactericidal are vancomycin and monoglycosidic; on the other hand, the examples of Bacteriostatic are spectinomycin, sulfonamides, etc.

Conclusion

The above discussion concludes that Bactericidal refers to the destruction of the bacterial cell; on the other hand, Bacteriostatic refers to the inhibition of growth of the bacterial cells.

Janet White

Janet White is a writer and blogger for Difference Wiki since 2015. She has a master's degree in science and medical journalism from Boston University. Apart from work, she enjoys exercising, reading, and spending time with her friends and family. Connect with her on Twitter @Janet__White