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Vaccinate vs. Inoculate: What's the Difference?

Vaccinate and Inoculate Definitions

Vaccinate

To inoculate with a vaccine in order to produce immunity to an infectious disease, such as diphtheria or typhus.

Inoculate

To introduce a serum, vaccine, or antigenic substance into (the body of a person or animal), especially to produce or boost immunity to a specific disease.

Vaccinate

To perform vaccinations or a vaccination.

Inoculate

To communicate a disease to (a living organism) by transferring its causative agent into the organism.

Vaccinate

(transitive) To treat (a person or an animal) with a vaccine to produce immunity against a disease.
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Inoculate

To implant microorganisms or infectious material into (a culture medium).

Vaccinate

To inoculate with the cowpox by means of a virus, called vaccine, taken either directly or indirectly from cows; now, generally, to administer (by injection or otherwise) any vaccine with the objective of rendering the recipient immune to an infectious disease. One who has been thus immunized by vaccination is said to be vaccinated against a particular disease. One may be thus immunized (vaccinated) also by oral ingestion or inhalation of a vaccine.

Inoculate

To safeguard as if by inoculation; protect
"A lapsed idealist, [she] has been inoculated against life's disappointments by her own skepticism" (John Lahr).

Vaccinate

Perform vaccinations or produce immunity in by inoculation;
We vaccinate against scarlet fever
The nurse vaccinated the children in the school

Inoculate

To introduce an idea or attitude into the mind of
"Young people ... are inoculated with the fervor, and are heard about the streets, singing the temperance songs" (Walt Whitman).
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Inoculate

To introduce an antigenic substance or vaccine into something (e.g. the body) or someone, such as to produce immunity to a specific disease.

Inoculate

To safeguard or protect something as if by inoculation.

Inoculate

To add one substance to another.
The culture medium was inoculated with selenium to investigate the rate of uptake.

Inoculate

To graft by inserting buds.
To inoculate the bud of one tree or plant into another
To inoculate a tree

Inoculate

(figurative) To introduce into the mind (used especially of harmful ideas or principles).
To inoculate someone with treason or infidelity

Inoculate

To bud; to insert, or graft, as the bud of a tree or plant in another tree or plant.

Inoculate

To insert a foreign bud into; as, to inoculate a tree.

Inoculate

To communicate a disease to (a person) by inserting infectious matter in the skin or flesh, especially as a means of inducing immunological resistance to that or related diseases; as, to inoculate a person with the virus of smallpox, rabies, etc. See Vaccinate.

Inoculate

Fig.: To introduce into the mind; - used especially of harmful ideas or principles; to imbue; as, to inoculate one with treason or infidelity.

Inoculate

To introduce microorganisms into (a growth medium), to cause the growth and multiplication of the microorganisms; as, to inoculate a fermentation vat with an actinomycete culture in order to produce streptomycin.

Inoculate

To graft by inserting buds.

Inoculate

To communicate disease by inoculation.

Inoculate

Introduce an idea or attitude into the mind of;
My teachers inoculated me with their beliefs

Inoculate

Introduce a micro-organism into

Inoculate

Perform vaccinations or produce immunity in by inoculation;
We vaccinate against scarlet fever
The nurse vaccinated the children in the school

Inoculate

Insert a bud for propagation

Inoculate

Impregnate with the virus or germ of a disease in order to render immune

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