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Prilosec vs. Prevacid: What's the Difference?

Edited by Aimie Carlson || By Janet White || Published on February 1, 2024
Prilosec (omeprazole) and Prevacid (lansoprazole) are both proton pump inhibitors (PPIs) used to treat acid-related stomach issues, differing mainly in chemical composition and dosage requirements.

Key Differences

Prilosec, known generically as omeprazole, and Prevacid, whose generic name is lansoprazole, are medications used in the treatment of gastroesophageal reflux disease (GERD) and other acid-related gastrointestinal conditions. While both are proton pump inhibitors, their chemical structures differ slightly, impacting how they are metabolized in the body.
In terms of effectiveness, both Prilosec and Prevacid are designed to reduce stomach acid production. However, the onset of action can differ, with Prevacid often taking effect more quickly than Prilosec. This difference can influence the choice of treatment in acute cases of acid reflux or heartburn.
Regarding side effects, Prilosec and Prevacid share common ones like headache, nausea, and diarrhea, but individual reactions can vary. Some patients may tolerate Prilosec better than Prevacid, or vice versa, due to the variations in their molecular formulations.
The dosage and duration of treatment with Prilosec and Prevacid can vary. Prilosec is often available in 20 mg capsules, while Prevacid is commonly found in 15 mg and 30 mg strengths. Physicians decide the appropriate dosage based on the patient's specific condition and response to the medication.
Both Prilosec and Prevacid are available over the counter, it's essential for patients to consult a healthcare provider for proper diagnosis and treatment recommendations. The choice between Prilosec and Prevacid depends on individual health profiles and specific medical needs.

Comparison Chart

Word Length

8 letters
8 letters


3 syllables (Pri-lo-sec)
3 syllables (Pre-va-cid)



Part of Speech

Noun (Brand name)
Noun (Brand name)

Origin of Name

Derived from its chemical name 'omeprazole'
Derived from its chemical name 'lansoprazole'

Prilosec and Prevacid Definitions


Prilosec acts as a proton pump inhibitor, reducing stomach acid.
Taking Prilosec has lessened my stomach discomfort.


Prevacid, a proton pump inhibitor, reduces the production of stomach acid.
My doctor recommended Prevacid to manage my acid production.


Prilosec is a brand name for the drug omeprazole.
My doctor prescribed Prilosec for my acid reflux.


Prevacid is also used in the treatment of peptic ulcers.
Since taking Prevacid, my ulcer symptoms have decreased.


Prilosec can be used for long-term management of Zollinger-Ellison Syndrome.
Prilosec is part of my treatment plan for Zollinger-Ellison Syndrome.


Prevacid is a brand name for the drug lansoprazole.
I switched from Prilosec to Prevacid for my GERD.


Prilosec is used to treat symptoms of gastroesophageal reflux disease (GERD).
Prilosec has helped reduce my heartburn significantly.


Prevacid is used to treat conditions like acid reflux and heartburn.
Prevacid has been effective in controlling my heartburn.


Prilosec is effective in treating peptic ulcers.
After starting Prilosec, my peptic ulcer symptoms improved.


Prevacid can be prescribed for erosive esophagitis.
My erosive esophagitis is being treated with Prevacid.


Antacid (trade name Prilosec) that suppresses acid secretion in the stomach


Antacid (trade name Prevacid) that suppresses acid secretion in the stomach


How long does it take for Prilosec and Prevacid to work?

They start working within one to four days, but full effect may take longer.

How do Prilosec and Prevacid work?

They reduce stomach acid by blocking the enzyme in the stomach wall.

Are Prilosec and Prevacid safe during pregnancy?

Consult a healthcare provider as risks may vary.

Can I buy Prilosec and Prevacid over the counter?

Yes, both are available OTC but should be used as directed.

Can children take Prilosec or Prevacid?

Yes, in specific doses prescribed by a pediatrician.

Can I take Prilosec or Prevacid with other medications?

Check with a doctor as they can interact with other drugs.

Is Prilosec or Prevacid better for GERD?

Effectiveness can vary; consult a doctor for a personal recommendation.

Are there any common side effects of Prilosec and Prevacid?

Common side effects include headache, nausea, and diarrhea.

What are Prilosec and Prevacid?

Both are proton pump inhibitors used to treat acid-related conditions.

Can Prilosec and Prevacid be used interchangeably?

While similar, they should only be swapped under medical advice.

Do Prilosec and Prevacid cure acid reflux?

They manage symptoms but don't cure the underlying cause.

What should I do if I miss a dose of Prilosec or Prevacid?

Take it as soon as you remember, but don't double up doses.

Is it safe to drink alcohol while taking Prilosec or Prevacid?

Alcohol can exacerbate acid reflux; moderation is key.

Are generic versions of Prilosec and Prevacid available?

Yes, generic forms omeprazole and lansoprazole are available.

How should Prilosec and Prevacid be stored?

Store in a cool, dry place away from direct sunlight.

Can Prilosec or Prevacid cause dependency?

Long-term use may lead to dependency; consult a doctor for guidance.

Do Prilosec and Prevacid have withdrawal symptoms?

Suddenly stopping them can lead to rebound acid hypersecretion.

How long can I take Prilosec or Prevacid?

Duration varies; long-term use should be monitored by a doctor.

Can Prilosec or Prevacid help with gas and bloating?

They're not primarily for gas and bloating but may indirectly help.

Can Prilosec or Prevacid cause weight gain?

Weight gain is not a common side effect but consult a doctor if concerned.
About Author
Written by
Janet White
Janet White has been an esteemed writer and blogger for Difference Wiki. Holding a Master's degree in Science and Medical Journalism from the prestigious Boston University, she has consistently demonstrated her expertise and passion for her field. When she's not immersed in her work, Janet relishes her time exercising, delving into a good book, and cherishing moments with friends and family.
Edited by
Aimie Carlson
Aimie Carlson, holding a master's degree in English literature, is a fervent English language enthusiast. She lends her writing talents to Difference Wiki, a prominent website that specializes in comparisons, offering readers insightful analyses that both captivate and inform.

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