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Magnesium Glycinate vs. Magnesium Gluconate: What's the Difference?

Edited by Aimie Carlson || By Harlon Moss || Published on January 14, 2024
Magnesium glycinate is a magnesium salt bonded to glycine, known for better absorption and less digestive upset; magnesium gluconate is magnesium with gluconic acid, often used for mild deficiencies.

Key Differences

Magnesium glycinate is a compound where magnesium is bonded with glycine, an amino acid. This form is praised for its high bioavailability and gentle effect on the stomach. Conversely, magnesium gluconate involves magnesium and gluconic acid, recognized for its effective absorption and suitability for treating low magnesium levels.
Magnesium glycinate is often preferred for its superior absorption and minimal gastrointestinal side effects, making it suitable for long-term use. Magnesium gluconate, while also well-absorbed, is typically chosen for short-term treatment of magnesium deficiency due to its effective replenishment capabilities.
People choose magnesium glycinate for its calming effects on the brain and muscles, leveraging the benefits of glycine. In contrast, magnesium gluconate is commonly used in clinical settings to quickly correct magnesium deficits in the body.
Magnesium glycinate is often recommended for individuals with chronic conditions requiring consistent magnesium supplementation without gastrointestinal distress. Magnesium gluconate, due to its specific formulation, is more suitable for conditions where rapid correction of magnesium levels is necessary.
Magnesium glycinate is widely available in health stores and is popular among those seeking supplements for stress and anxiety relief. Magnesium gluconate is also commonly found but is often sought after for immediate magnesium replenishment purposes.

Comparison Chart

Chemical Bonding

Bonded with glycine
Bonded with gluconic acid


High bioavailability
Effectively absorbed

Digestive Effects

Gentle on the stomach
Generally well-tolerated

Primary Use

Long-term supplementation, stress relief
Short-term magnesium deficiency correction

Therapeutic Effect

Calming, beneficial for brain and muscles
Rapid magnesium replenishment

Magnesium Glycinate and Magnesium Gluconate Definitions

Magnesium Glycinate

Combines magnesium's benefits with the calming effect of glycine.
Magnesium glycinate helps me manage my muscle cramps.

Magnesium Gluconate

Used for treating mild magnesium deficiencies.
Magnesium gluconate quickly improved my magnesium levels.

Magnesium Glycinate

A magnesium salt combined with glycine.
I take magnesium glycinate at night for better sleep.

Magnesium Gluconate

A compound of magnesium and gluconic acid.
I was prescribed magnesium gluconate for my magnesium deficiency.

Magnesium Glycinate

Preferred for long-term magnesium supplementation.
My doctor recommended magnesium glycinate for my daily routine.

Magnesium Gluconate

Often used in clinical settings for rapid correction.
In the hospital, they gave me magnesium gluconate to replenish my levels.

Magnesium Glycinate

Known for high absorption and minimal gastrointestinal impact.
Magnesium glycinate is my choice due to its easy digestibility.

Magnesium Gluconate

Well-tolerated with effective absorption.
Magnesium gluconate didn't upset my stomach like other supplements.

Magnesium Glycinate

Often used for stress relief and muscle relaxation.
After starting magnesium glycinate, I feel less anxious.

Magnesium Gluconate

Suitable for short-term therapeutic use.
My doctor suggested magnesium gluconate for a few weeks only.


Is magnesium glycinate better absorbed than magnesium gluconate?

Yes, magnesium glycinate is known for its superior absorption.

What is magnesium glycinate?

A magnesium salt bonded with glycine, known for good absorption and minimal side effects.

What is magnesium gluconate?

A compound of magnesium and gluconic acid, used for correcting mild magnesium deficiencies.

Is magnesium glycinate good for sleep?

Yes, it's often used for its calming effects, which can aid sleep.

Is magnesium gluconate fast-acting for deficiency?

Yes, it's effective for rapid magnesium level correction.

Can I take magnesium glycinate daily?

Yes, it's suitable for long-term use due to its gentle nature.

Does magnesium gluconate interact with medications?

It can, so consult a doctor if you're on medication.

Can magnesium gluconate cause digestive issues?

It is generally well-tolerated, but individual responses may vary.

Is magnesium gluconate available over-the-counter?

Yes, it's commonly available in pharmacies.

Can magnesium glycinate improve muscle function?

Yes, it's beneficial for muscle relaxation and function.

Does magnesium glycinate help with anxiety?

Many users report reduced anxiety due to its calming properties.

Is magnesium gluconate good for heart health?

Yes, as correcting magnesium deficiency can benefit heart health.

Can magnesium glycinate cause diarrhea?

It's less likely to cause gastrointestinal issues compared to other forms.

Does magnesium glycinate aid in bone health?

Yes, magnesium is vital for bone health.

Is magnesium glycinate vegan-friendly?

Most products are, but check individual labels for confirmation.

Is magnesium gluconate safe for kidney disease?

Caution is advised; consult a healthcare provider.

Does magnesium glycinate interact with calcium absorption?

It can; balanced intake with calcium is recommended.

How quickly does magnesium gluconate work?

It can start working within hours, but full effects vary individually.

Can I take magnesium gluconate during pregnancy?

Consult a doctor, as individual needs may vary.

Is magnesium gluconate suitable for children?

It should be used under medical supervision for children.
About Author
Written by
Harlon Moss
Harlon is a seasoned quality moderator and accomplished content writer for Difference Wiki. An alumnus of the prestigious University of California, he earned his degree in Computer Science. Leveraging his academic background, Harlon brings a meticulous and informed perspective to his work, ensuring content accuracy and excellence.
Edited by
Aimie Carlson
Aimie Carlson, holding a master's degree in English literature, is a fervent English language enthusiast. She lends her writing talents to Difference Wiki, a prominent website that specializes in comparisons, offering readers insightful analyses that both captivate and inform.

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