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Lidocaine vs. Septocaine: What's the Difference?

Edited by Janet White || By Harlon Moss || Published on January 30, 2024
Lidocaine is a local anesthetic commonly used in minor surgeries and dental procedures. Septocaine is a local anesthetic, known as articaine, used primarily in dentistry for its potent and long-lasting effects.

Key Differences

Lidocaine is a widely used local anesthetic in various medical procedures, known for its effectiveness in numbing targeted areas. Septocaine, which is a brand name for articaine, is also used as a local anesthetic, primarily in dental procedures, and is known for its rapid onset and potency.
Lidocaine has a range of applications beyond anesthesia, such as in treating heart rhythm disturbances. In contrast, Septocaine is more specifically used in dental settings, providing profound anesthesia for procedures like tooth extractions.
Both lidocaine and septocaine are effective in blocking nerve impulses to ensure painless procedures, septocaine is often preferred in dentistry due to its stronger and longer-lasting effects. Lidocaine, however, is more versatile in its application.
Lidocaine is also available in various forms, including gels, creams, and injections, making it suitable for different types of medical and cosmetic procedures. Septocaine, however, is mainly available as an injectable solution in dentistry.
In terms of molecular structure, lidocaine and septocaine differ slightly, influencing their pharmacokinetic properties. Lidocaine is metabolized primarily in the liver, while septocaine has a unique metabolism pathway, partially in the blood and liver, contributing to its rapid onset.

Comparison Chart

Primary Use

Various medical and dental procedures
Primarily in dental procedures


Anesthesia, heart rhythm disturbances, topical use
Profound dental anesthesia

Form Available

Gels, creams, injections
Mainly injectable solutions

Effect Duration

Moderate duration
Longer-lasting effects


Primarily in the liver
Partially in the blood and liver, rapid onset

Lidocaine and Septocaine Definitions


Often used in dental procedures to numb the area.
Lidocaine was injected to numb the tooth before extraction.


Effective in blocking nerve impulses in dental procedures.
Septocaine ensured the patient felt no pain during the tooth extraction.


A local anesthetic for minor surgeries.
Lidocaine was applied to numb the area before stitching the wound.


Has a unique metabolism, partly in the blood.
The rapid action of septocaine is due to its unique metabolic pathway.


Used in treating heart rhythm disturbances.
The patient was administered lidocaine for their arrhythmia.


A potent local anesthetic used in dentistry.
Septocaine was administered for a pain-free root canal procedure.


Can be used for nerve block injections.
A lidocaine nerve block was given to alleviate chronic pain.


Known for its rapid onset of action.
The dentist chose septocaine for its quick numbing effect.


Available as a topical gel for numbing skin.
The lidocaine gel was used before the laser hair removal procedure.


Articaine hydrochloride used in dental anesthesia.
Septocaine is preferred for longer dental surgeries for its lasting effect.


A synthetic amide, C14H22N2O, used chiefly in the form of its hydrochloride as a local anesthetic and antiarrhythmic agent.


(pharmaceutical drug) A crystalline compound C14H22N2O that is used in the form of its hydrochloride as a local anesthetic and as an antiarrhythmic agent.


A local anesthetic (trade names Lidocaine and Xylocaine) used topically on the skin and mucous membranes


What is lidocaine commonly used for?

Lidocaine is commonly used as a local anesthetic in various medical procedures.

How does lidocaine help with heart issues?

Lidocaine can treat certain types of heart rhythm disturbances.

What sets septocaine apart in dentistry?

Septocaine is known for its potency and long-lasting effects in dental anesthesia.

Can lidocaine be used topically?

Yes, lidocaine is available in topical forms like gels and creams.

Can lidocaine be used for nerve blocks?

Yes, lidocaine is effective for nerve block injections to manage pain.

Is septocaine better than lidocaine for dental work?

Septocaine is often preferred in dentistry for its stronger and longer-lasting effects.

What is the main form in which septocaine is available?

Septocaine is primarily available as an injectable solution.

How quickly does septocaine take effect?

Septocaine has a rapid onset, making it effective soon after administration.

Is lidocaine safe for all ages?

Lidocaine is generally safe but should be used cautiously in certain age groups and conditions.

Is septocaine effective for all dental procedures?

Septocaine is effective for most dental procedures, especially where deep anesthesia is needed.

Can lidocaine be used in cosmetic procedures?

Yes, lidocaine is often used in cosmetic procedures for numbing.

Can lidocaine be used in emergency medicine?

Yes, lidocaine is used in emergency medicine for its anesthetic and antiarrhythmic properties.

What are the precautions for using lidocaine?

Precautions include considering allergies, heart conditions, and liver function.

Can septocaine be used for children in dentistry?

Septocaine can be used in pediatric dentistry, but dosage must be carefully adjusted.

Why is septocaine preferred for longer dental surgeries?

Its longer-lasting effects make septocaine suitable for prolonged dental procedures.

How is lidocaine metabolized in the body?

Lidocaine is primarily metabolized in the liver.

What type of drug is septocaine?

Septocaine is a local anesthetic, specifically articaine hydrochloride.

Does lidocaine have any side effects?

Like any drug, lidocaine can have side effects, but they are generally mild.

What is the metabolic pathway of septocaine?

Septocaine is metabolized partially in the blood and liver.

Does septocaine numb immediately?

Septocaine acts quickly, providing numbing effects shortly after administration.
About Author
Written by
Harlon Moss
Harlon is a seasoned quality moderator and accomplished content writer for Difference Wiki. An alumnus of the prestigious University of California, he earned his degree in Computer Science. Leveraging his academic background, Harlon brings a meticulous and informed perspective to his work, ensuring content accuracy and excellence.
Edited by
Janet White
Janet White has been an esteemed writer and blogger for Difference Wiki. Holding a Master's degree in Science and Medical Journalism from the prestigious Boston University, she has consistently demonstrated her expertise and passion for her field. When she's not immersed in her work, Janet relishes her time exercising, delving into a good book, and cherishing moments with friends and family.

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