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L Glutamine vs. Glutathione: What's the Difference?

Edited by Aimie Carlson || By Janet White || Published on December 28, 2023
L-Glutamine is an amino acid important for muscle function and gut health, while glutathione is a powerful antioxidant that protects cells from oxidative stress.

Key Differences

L-Glutamine, an amino acid, is a building block for proteins and crucial in muscle repair. Glutathione, a tripeptide, acts primarily as an antioxidant, protecting cells from damage.
L-Glutamine supports intestinal health and immune function. Glutathione contributes to detoxification processes and immune defense.
The body synthesizes L-Glutamine, and it's also found in foods. Glutathione, synthesized in cells, relies on precursor amino acids for its production.
Supplemental L-Glutamine is used for muscle recovery and gut health. Glutathione supplements are taken for liver health and anti-aging effects.
L-Glutamine plays a role in energy production. Glutathione helps in regenerating vitamins C and E, enhancing their antioxidant properties.

Comparison Chart


Amino acid for protein synthesis and muscle repair
Antioxidant for cellular protection

Role in Body

Supports gut and immune health
Aids in detoxification and immune defense


Body synthesis and diet
Synthesized in cells from amino acids

Supplemental Use

For muscle recovery, gut health
For liver health, anti-aging

Biological Importance

Crucial in energy production
Regenerates other antioxidants

L Glutamine and Glutathione Definitions

L Glutamine

It helps in protein synthesis and energy production.
L-Glutamine is added to some nutritional supplements for its energy-boosting properties.


Glutathione is a key antioxidant protecting cells from damage.
Glutathione levels decrease with age, impacting cellular health.

L Glutamine

L-Glutamine is a fuel source for immune and intestinal cells.
During illness, the body's demand for L-Glutamine increases.


It aids in detoxifying harmful substances.
Glutathione plays a critical role in liver detoxification processes.

L Glutamine

L-Glutamine is a vital amino acid for muscle repair.
Athletes often take L-Glutamine supplements for quicker muscle recovery.


It helps regenerate other antioxidants.
Glutathione reactivates vitamins C and E to their active forms.

L Glutamine

It supports gut health and immune function.
L-Glutamine is essential for maintaining intestinal barrier function.


Glutathione supports the immune system.
Adequate glutathione levels are crucial for optimal immune function.

L Glutamine

L-Glutamine can be synthesized in the body.
The body produces L-Glutamine, but levels can be depleted during intense exercise.


Glutathione is made from three amino acids.
Cysteine, glutamic acid, and glycine combine to form glutathione.


A tripeptide, C10H17N3O6S, of glycine, cysteine, and glutamic acid that occurs widely in plant and animal tissues and is important in biological oxidation-reduction reactions.


(biochemistry) A tripeptide formed from glutamic acid, cysteine and glycine, that is active in many biological redox reactions


What's the role of Glutathione in the body?

It protects cells from oxidative stress.

What is L-Glutamine?

An amino acid important for muscle and gut health.

Can L-Glutamine improve gut health?

Yes, it strengthens the intestinal lining.

How does L-Glutamine support muscles?

It aids in muscle repair and recovery.

How does Glutathione aid detoxification?

By neutralizing and eliminating toxins.

What is Glutathione?

A tripeptide that acts as a powerful antioxidant.

Can diet affect Glutathione levels?

Yes, certain foods boost its production.

Should athletes take L-Glutamine?

It's beneficial for muscle recovery post-exercise.

Is supplementing with L-Glutamine safe?

Generally yes, but consult a healthcare provider.

What happens when L-Glutamine levels are low?

It can lead to muscle wasting and weakened immunity.

Is L-Glutamine naturally produced in the body?

Yes, but levels can be low in stress.

What foods are rich in L-Glutamine?

Sources include meat, eggs, and dairy products.

Can Glutathione supplements improve skin health?

Yes, due to its antioxidant properties.

Does Glutathione help with liver function?

Yes, it's crucial for liver detoxification.

Can L-Glutamine help with weight loss?

It's not a weight loss supplement but may aid in muscle metabolism.

Does Glutathione have anti-aging effects?

Yes, it helps reduce cellular damage associated with aging.

Can L-Glutamine support the immune system?

Yes, it's a key fuel for immune cells.

How is Glutathione synthesized?

It's produced from cysteine, glutamic acid, and glycine.

Is Glutathione effective in oral supplement form?

Its effectiveness can vary; some forms are more absorbable.

How does exercise impact L-Glutamine levels?

Intense exercise can deplete L-Glutamine reserves.
About Author
Written by
Janet White
Janet White has been an esteemed writer and blogger for Difference Wiki. Holding a Master's degree in Science and Medical Journalism from the prestigious Boston University, she has consistently demonstrated her expertise and passion for her field. When she's not immersed in her work, Janet relishes her time exercising, delving into a good book, and cherishing moments with friends and family.
Edited by
Aimie Carlson
Aimie Carlson, holding a master's degree in English literature, is a fervent English language enthusiast. She lends her writing talents to Difference Wiki, a prominent website that specializes in comparisons, offering readers insightful analyses that both captivate and inform.

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