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ITP vs. TTP: What's the Difference?

Edited by Aimie Carlson || By Janet White || Published on February 2, 2024
ITP (Idiopathic Thrombocytopenic Purpura) is an autoimmune disorder causing low platelet counts, while TTP (Thrombotic Thrombocytopenic Purpura) is a rare blood disorder causing blood clots in small vessels.

Key Differences

ITP, or Idiopathic Thrombocytopenic Purpura, is a condition where the immune system attacks platelets, leading to bleeding and bruising. TTP, or Thrombotic Thrombocytopenic Purpura, involves the formation of blood clots in small blood vessels, which can lead to organ damage.
In ITP, symptoms include easy bruising, bleeding gums, and petechiae. TTP symptoms are more severe, including neurological symptoms like headaches and confusion, due to reduced blood flow to organs.
The cause of ITP is often unknown and considered idiopathic, while TTP can be triggered by various factors, including infections, pregnancy, and certain medications.
Treatment for ITP typically involves steroids, immunoglobulins, and sometimes spleen removal. TTP treatment usually requires plasma exchange therapy and medications to prevent blood clots.
ITP can occur at any age but is more common in children and women. TTP is rare and can be life-threatening, requiring immediate medical attention.

Comparison Chart

Full Name

Idiopathic Thrombocytopenic Purpura
Thrombotic Thrombocytopenic Purpura

Main Symptom

Low platelet count leading to bleeding
Formation of blood clots in small vessels

Typical Symptoms

Bruising, bleeding gums, petechiae
Neurological issues, kidney problems, fever

Common Causes

Autoimmune response, often idiopathic
Infections, genetic factors, certain drugs

Treatment Approaches

Steroids, immunoglobulins, splenectomy
Plasma exchange, clot-preventing drugs


Common in children and women
Rare, affecting adults more often

ITP and TTP Definitions


ITP can cause easy bruising and bleeding.
Small, red spots on his skin were a sign of ITP.


It can lead to reduced blood flow and organ damage.
His TTP led to complications in kidney function.


Treatment may involve steroids and immunoglobulins.
She received immunoglobulin therapy for her ITP.


Symptoms include neurological issues and fever.
The patient with TTP was confused and had a high fever.


ITP is an autoimmune disorder leading to low platelet counts.
The patient with ITP had frequent nosebleeds.


TTP can be triggered by infections or certain medications.
Her TTP was thought to be triggered by a recent infection.


It's often idiopathic, with unknown causes.
Despite extensive tests, the cause of her ITP remained a mystery.


TTP is a blood disorder causing clots in small vessels.
She was diagnosed with TTP after experiencing severe headaches.


It's more common in children and women.
The young girl was diagnosed with ITP after excessive bruising.


Treatment often involves plasma exchange therapy.
He underwent plasma exchange as part of his TTP treatment.


What causes ITP?

Often unknown; it's an autoimmune response.

Who is more likely to get ITP?

It's more common in children and women.

What does TTP stand for?

Thrombotic Thrombocytopenic Purpura.

What causes TTP?

Factors like infections, genetics, and certain drugs.

What are the signs of TTP?

Symptoms include neurological problems, fever, and kidney issues.

Can ITP lead to serious bleeding?

Yes, due to low platelet counts.

What does ITP stand for?

Idiopathic Thrombocytopenic Purpura.

Is TTP a rare condition?

Yes, it's relatively rare and can be life-threatening.

What treatments are available for ITP?

Options include steroids, immunoglobulins, and splenectomy.

Can ITP become chronic?

Yes, in some cases, it can be a chronic condition.

Can ITP lead to other health issues?

Severe cases can lead to significant bleeding problems.

How is ITP diagnosed?

Through blood tests and clinical evaluation.

Does TTP affect specific organs?

It can affect various organs, especially the brain and kidneys.

Can TTP be cured?

With prompt treatment, many patients can recover.

Is ITP a genetic condition?

It's not typically considered genetic.

Are there genetic forms of TTP?

Some forms can be linked to genetic factors.

Is TTP an emergency condition?

Yes, it requires immediate medical attention.

How is TTP diagnosed?

Diagnosis involves blood tests and sometimes imaging studies.

Is there a cure for ITP?

Treatments can manage symptoms, but there's no guaranteed cure.

What's the main treatment for TTP?

Plasma exchange therapy and anticoagulant medications.
About Author
Written by
Janet White
Janet White has been an esteemed writer and blogger for Difference Wiki. Holding a Master's degree in Science and Medical Journalism from the prestigious Boston University, she has consistently demonstrated her expertise and passion for her field. When she's not immersed in her work, Janet relishes her time exercising, delving into a good book, and cherishing moments with friends and family.
Edited by
Aimie Carlson
Aimie Carlson, holding a master's degree in English literature, is a fervent English language enthusiast. She lends her writing talents to Difference Wiki, a prominent website that specializes in comparisons, offering readers insightful analyses that both captivate and inform.

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