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Excedrin Migraine vs. Excedrin Extra Strength: What's the Difference?

Edited by Aimie Carlson || By Janet White || Published on February 26, 2024
Excedrin Migraine is formulated specifically for migraine relief, containing aspirin, acetaminophen, and caffeine. Excedrin Extra Strength is designed for general pain relief with the same ingredients but different intended uses.

Key Differences

Excedrin Migraine is tailored for the relief of migraine symptoms, including nausea and light sensitivity, along with pain. Excedrin Extra Strength, while having the same ingredients, is marketed for general pain relief, such as headaches, muscle aches, and toothaches. Both contain a combination of aspirin, acetaminophen, and caffeine but are labeled and marketed for these different uses.
The U.S. Food and Drug Administration (FDA) has approved Excedrin Migraine specifically for migraine treatment. This distinction in labeling means that Excedrin Migraine comes with specific instructions and dosage for migraine sufferers. In contrast, Excedrin Extra Strength is approved for general pain relief and lacks these specific migraine-related instructions.
The recommended dosage may vary between Excedrin Migraine and Excedrin Extra Strength, especially concerning how often the medication can be taken for migraine versus general pain.
Excedrin Migraine is often perceived and marketed as a more specialized form of pain relief, specifically targeting migraine symptoms, whereas Excedrin Extra Strength is viewed as a more versatile, general pain reliever.
There may be differences in price and availability between the two products, influenced by their marketed uses. Excedrin Migraine, being a more specialized product, might sometimes be priced differently than Excedrin Extra Strength.

Comparison Chart

Primary Use

Specifically for migraine relief
For general pain relief

FDA Approval

Approved for migraine treatment
Approved for general pain relief


Aspirin, Acetaminophen, Caffeine
Aspirin, Acetaminophen, Caffeine

Recommended Dosage

Specific to migraine relief
General pain relief dosage

Marketing Focus

Targeted towards individuals with migraines
Marketed as a versatile pain reliever

Excedrin Migraine and Excedrin Extra Strength Definitions

Excedrin Migraine

A pain reliever tailored for migraine sufferers.
Excedrin Migraine is her go-to medication for severe migraine attacks.

Excedrin Extra Strength

Effective for headaches, muscle aches, and other pains.
She keeps Excedrin Extra Strength on hand for occasional aches and pains.

Excedrin Migraine

Approved specifically for treating migraine headaches.
He chose Excedrin Migraine because it's FDA-approved for migraines.

Excedrin Extra Strength

Popular for its effectiveness in general pain relief.
Excedrin Extra Strength is her preferred choice for quick pain relief.

Excedrin Migraine

Contains aspirin, acetaminophen, and caffeine.
Excedrin Migraine's combination of ingredients effectively alleviates her migraine pain.

Excedrin Extra Strength

Designed to alleviate various types of pain.
He took Excedrin Extra Strength for his backache.

Excedrin Migraine

A medication specifically formulated to relieve migraines.
She took Excedrin Migraine at the onset of her migraine symptoms.

Excedrin Extra Strength

Not specifically labeled for migraine relief.
For his toothache, he chose Excedrin Extra Strength.

Excedrin Migraine

Aims to relieve migraine symptoms like nausea and light sensitivity.
Excedrin Migraine helps reduce her migraine-related nausea.

Excedrin Extra Strength

Contains aspirin, acetaminophen, and caffeine.
Excedrin Extra Strength's formula helps with his tension headaches.


Can I use Excedrin Extra Strength for migraines?

While it contains the same ingredients, it's not specifically labeled for migraines.

How quickly does Excedrin Migraine work?

It varies, but some people experience relief within 30 minutes.

Can children take Excedrin Extra Strength?

It's not recommended for children under 12 without doctor's advice.

Are the ingredients in Excedrin Migraine and Excedrin Extra Strength the same?

Yes, both contain aspirin, acetaminophen, and caffeine.

Is Excedrin Extra Strength suitable for everyday pain?

Yes, it's effective for various everyday pains like headaches and muscle aches.

Can Excedrin Migraine prevent migraine attacks?

It's intended for symptom relief and not for migraine prevention.

Does Excedrin Migraine interact with other medications?

Yes, it can interact with certain medications, so consult a doctor if you're taking other drugs.

Are there any side effects of Excedrin Migraine?

Common side effects can include nausea, heartburn, and increased heart rate.

Is there a difference in dosing between the two products?

The recommended dosages may vary, especially for migraine treatment.

Is Excedrin Migraine safe for daily use?

Prolonged daily use can lead to medication overuse headaches.

Can I take Excedrin Migraine for a regular headache?

While it's formulated for migraines, it can also be effective for regular headaches.

Is Excedrin Migraine effective for cluster headaches?

It's specifically formulated for migraines, so it may not be as effective for cluster headaches.

Are there any long-term risks with Excedrin Extra Strength?

Long-term use can lead to complications like gastrointestinal issues or medication overuse headaches.

How should I store Excedrin Migraine and Excedrin Extra Strength?

Store in a cool, dry place, away from direct sunlight and moisture.

Can Excedrin Extra Strength be taken with alcohol?

It's advisable to avoid alcohol while taking these medications due to increased risk of stomach bleeding.

Can I take Excedrin Extra Strength on an empty stomach?

Taking it with food may help reduce stomach irritation.

How often can I take Excedrin Extra Strength?

Follow the instructions on the package, typically not exceeding the recommended dosage in 24 hours.

What are the caffeine contents in these medications?

Both contain caffeine, which helps increase pain relief effectiveness.

Can pregnant women take Excedrin Migraine?

Pregnant women should consult their doctor before taking any medication, including Excedrin Migraine.

Is Excedrin Extra Strength non-drowsy?

Yes, it's a non-drowsy formula, though individual reactions may vary.
About Author
Written by
Janet White
Janet White has been an esteemed writer and blogger for Difference Wiki. Holding a Master's degree in Science and Medical Journalism from the prestigious Boston University, she has consistently demonstrated her expertise and passion for her field. When she's not immersed in her work, Janet relishes her time exercising, delving into a good book, and cherishing moments with friends and family.
Edited by
Aimie Carlson
Aimie Carlson, holding a master's degree in English literature, is a fervent English language enthusiast. She lends her writing talents to Difference Wiki, a prominent website that specializes in comparisons, offering readers insightful analyses that both captivate and inform.

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