Amlodipine vs. Amlodipine Besylate: What's the Difference?
Amlodipine is a calcium channel blocker used to treat hypertension, while amlodipine besylate is the besylate salt form of amlodipine, more stable and easier to formulate in medications.
Amlodipine is a drug in the dihydropyridine class of calcium channel blockers. While, amlodipine besylate is the same drug in a salt form, combined with benzenesulfonate (besylate) for stability.
The pure form of amlodipine is rarely used in medications due to stability issues. Amlodipine besylate, on the other hand, is commonly used in pharmaceuticals due to its improved stability and solubility.
Both are used to treat high blood pressure and angina, but the besylate form is more commonly prescribed due to its formulation. The effectiveness of both in treating cardiovascular conditions is the same.
In the body, amlodipine besylate converts to amlodipine, meaning their bioavailability and absorption rates are essentially the same.
The pharmacokinetics, including how the body metabolizes and eliminates the drug, are the same for both forms. The besylate component does not significantly alter the drug’s action.
Pure drug form
Salt form with besylate
Stability in Formulation
Less stable, rarely used in pure form
More stable, commonly used in medications
Treats hypertension and angina
Same uses, more prevalent in prescriptions
Converts to amlodipine in the body, similar effect
Same metabolic process
Same, with the besylate component being inert
Amlodipine and Amlodipine Besylate Definitions
A calcium channel blocker medication.
Amlodipine is prescribed for high blood pressure control.
Has the same therapeutic effects as amlodipine.
Amlodipine besylate effectively treats angina, just like amlodipine.
Used in the treatment of angina and coronary artery disease.
Doctors often recommend amlodipine for chest pain relief.
Facilitates easier manufacturing and storage of the drug.
Pharmaceutical companies prefer amlodipine besylate for production.
Works by relaxing blood vessels and improving blood flow.
Amlodipine helps in reducing the risk of stroke and heart attack.
Offers improved stability over pure amlodipine.
Due to its stability, amlodipine besylate has a longer shelf life.
Belongs to the dihydropyridine class of drugs.
As a dihydropyridine, amlodipine has fewer cardiac side effects.
Converts to amlodipine in the body after ingestion.
Once ingested, amlodipine besylate effectively lowers blood pressure.
Can be used alone or with other medications.
Amlodipine is sometimes combined with other antihypertensives.
The besylate salt form of amlodipine.
Amlodipine besylate is more commonly used in pill formulations.
(pharmaceutical drug) A long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina
What is amlodipine besylate?
The besylate salt form of amlodipine, used for the same purposes.
Can amlodipine treat heart failure?
It's not the primary treatment but can be used to manage symptoms.
What is amlodipine?
A calcium channel blocker used to treat hypertension and angina.
Does amlodipine have side effects?
Possible side effects include dizziness, swelling, or fatigue.
Are the effects of amlodipine and its besylate form different?
No, they have the same therapeutic effect.
Is amlodipine effective for high blood pressure?
Very effective in lowering and managing blood pressure.
Why is amlodipine besylate more common?
It’s more stable and easier to manufacture.
Can amlodipine besylate cause drowsiness?
Drowsiness is a possible side effect.
Does amlodipine besylate interact with other drugs?
Yes, it can interact with certain drugs, so consultation is important.
Can amlodipine cause weight gain?
Weight gain is a rare but possible side effect.
Is amlodipine besylate available over the counter?
No, it requires a doctor's prescription.
Does amlodipine affect kidney function?
It can be used safely in patients with kidney disease, with monitoring.
Can amlodipine besylate be stopped abruptly?
Stopping suddenly is not recommended; tapering is safer.
Is amlodipine besylate safe for long-term use?
Yes, under medical supervision.
How should amlodipine be taken?
Usually taken once daily, with or without food.
Can amlodipine besylate be used in pregnancy?
Its use in pregnancy should be discussed with a doctor.
How is amlodipine besylate metabolized?
It’s metabolized in the liver and excreted in urine.
Is amlodipine suitable for elderly patients?
Yes, but with careful dose adjustments and monitoring.
How long does amlodipine take to work?
It starts working within a few hours, but full effect may take weeks.
Can amlodipine besylate cause coughing?
Coughing is a less common side effect compared to other blood pressure medications.
Written bySumera Saeed
Sumera is an experienced content writer and editor with a niche in comparative analysis. At Diffeence Wiki, she crafts clear and unbiased comparisons to guide readers in making informed decisions. With a dedication to thorough research and quality, Sumera's work stands out in the digital realm. Off the clock, she enjoys reading and exploring diverse cultures.
Edited byHuma Saeed
Huma is a renowned researcher acclaimed for her innovative work in Difference Wiki. Her dedication has led to key breakthroughs, establishing her prominence in academia. Her contributions continually inspire and guide her field.