Alpha Lipoic Acid vs. R-Lipoic Acid: What's the Difference?
Edited by Janet White || By Harlon Moss || Updated on October 27, 2023
Alpha lipoic acid is a naturally occurring compound, while R-lipoic acid is its biologically active form.
Key Differences
Alpha lipoic acid (ALA) is a versatile antioxidant found in the mitochondria of cells. It has the ability to neutralize a variety of free radicals. R-lipoic acid is the naturally occurring form of ALA, present in our bodies and certain foods.
R-lipoic acid is often considered superior because it's more bioavailable and effective as an antioxidant than the synthetic versions of ALA. Both alpha lipoic acid and r-lipoic acid can be consumed as dietary supplements.
In terms of chemical structure, alpha lipoic acid can exist in two isomeric forms: R and S. R-lipoic acid refers to the R-isomer, which is biologically active and beneficial for the body.
When buying supplements, consumers often see "alpha lipoic acid" on labels, but it's essential to check if it specifies whether it's the more effective R-lipoic acid or a mixture of both R and S forms.
Comparison Chart
Chemical Structure
Exists in two isomeric forms (R and S)
Only the R-isomer
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Bioavailability
Lower compared to R-lipoic acid
Higher and more readily absorbed by the body
Effectiveness
Less effective as an antioxidant
More effective as an antioxidant
Natural Occurrence
Found in every cell of the body
The biologically active form in the body
Dietary Supplements
Often doesn't specify the type on labels
Explicitly labeled, usually more expensive
Alpha Lipoic Acid and R-Lipoic Acid Definitions
Alpha Lipoic Acid
Alpha lipoic acid helps to regenerate other antioxidants in the body.
Due to its regenerative properties, alpha lipoic acid prolongs the life of vitamins C and E.
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R-Lipoic Acid
R-lipoic acid is the biologically active form of alpha lipoic acid.
For enhanced benefits, some prefer supplements with r-lipoic acid over the mixed form.
Alpha Lipoic Acid
Alpha lipoic acid can exist in both R and S forms.
When choosing a supplement, it's essential to know if the alpha lipoic acid is the R or S form.
R-Lipoic Acid
R-lipoic acid has higher bioavailability than its counterpart.
Due to its bioavailability, r-lipoic acid is absorbed better by the body.
Alpha Lipoic Acid
Alpha lipoic acid is sometimes used to help manage diabetic symptoms.
Consult your doctor before taking alpha lipoic acid for diabetic neuropathy.
R-Lipoic Acid
R-lipoic acid supplements are usually explicitly labeled and can be more expensive.
While r-lipoic acid supplements are pricier, many believe the benefits justify the cost.
Alpha Lipoic Acid
Alpha lipoic acid is an antioxidant compound found in the body.
Many take alpha lipoic acid supplements for its antioxidant benefits.
R-Lipoic Acid
R-lipoic acid exhibits strong antioxidant properties.
Studies have shown r-lipoic acid's prowess in neutralizing harmful free radicals.
Alpha Lipoic Acid
Alpha lipoic acid plays a role in energy production in cells.
Within our cells, alpha lipoic acid has a crucial role in producing energy.
R-Lipoic Acid
R-lipoic acid is the naturally occurring isomer in the human body.
Our bodies naturally produce and utilize r-lipoic acid for various functions.
FAQs
Is one more effective than the other?
R-lipoic acid is typically more effective and bioavailable than generic alpha lipoic acid.
How does r-lipoic acid differ from alpha lipoic acid?
R-lipoic acid is the biologically active form of alpha lipoic acid.
Can I find both alpha lipoic acid and r-lipoic acid in supplements?
Yes, both are available in supplements, but r-lipoic acid is often considered more bioavailable.
Why is r-lipoic acid often more expensive?
R-lipoic acid's production is more intricate, and it's often considered superior due to its bioavailability.
Can both forms help in nerve-related conditions?
Some studies suggest potential benefits in conditions like diabetic neuropathy, but always consult a doctor.
Do alpha lipoic acid and r-lipoic acid interact with medications?
Possible interactions exist, especially with diabetes medications. Always consult a healthcare professional.
Is there a difference in safety between alpha lipoic acid and r-lipoic acid?
Both are generally considered safe, but always consider dosage and potential interactions.
What is alpha lipoic acid?
Alpha lipoic acid is a naturally occurring antioxidant compound found in the body.
Can alpha lipoic acid help with skin aging?
Some studies suggest that alpha lipoic acid can benefit skin health due to its antioxidant properties.
Are there food sources for alpha lipoic acid and r-lipoic acid?
Both can be found in foods like spinach, broccoli, and organ meats, though in small amounts.
Do alpha lipoic acid and r-lipoic acid help with weight loss?
Some studies suggest potential benefits, but results are inconclusive.
Are there any health benefits associated with alpha lipoic acid and r-lipoic acid?
Both compounds are known for their antioxidant properties and potential in managing diabetic symptoms.
What's the recommended dose for these supplements?
Doses vary; always consult a healthcare professional before starting any supplementation.
Are there any side effects?
Some may experience side effects, like skin rashes or upset stomach, with either alpha lipoic acid or r-lipoic acid supplements.
What is the primary function of alpha lipoic acid in the body?
Alpha lipoic acid plays a role in energy production in cells and acts as an antioxidant.
Is r-lipoic acid the only active form of alpha lipoic acid?
Yes, r-lipoic acid is the biologically active isomer.
Is alpha lipoic acid water or fat-soluble?
Alpha lipoic acid is both water and fat-soluble, allowing it to work in various parts of the body.
Can I take alpha lipoic acid and r-lipoic acid together?
While they're essentially different forms of the same compound, consult a doctor for combined supplementation.
Do I need to take supplements of alpha lipoic acid or r-lipoic acid?
Not necessarily. The body produces it naturally, but some take supplements for additional benefits.
How are the antioxidant properties of alpha lipoic acid beneficial?
They can neutralize free radicals, supporting overall cellular health.
About Author
Written by
Harlon MossHarlon is a seasoned quality moderator and accomplished content writer for Difference Wiki. An alumnus of the prestigious University of California, he earned his degree in Computer Science. Leveraging his academic background, Harlon brings a meticulous and informed perspective to his work, ensuring content accuracy and excellence.
Edited by
Janet WhiteJanet White has been an esteemed writer and blogger for Difference Wiki. Holding a Master's degree in Science and Medical Journalism from the prestigious Boston University, she has consistently demonstrated her expertise and passion for her field. When she's not immersed in her work, Janet relishes her time exercising, delving into a good book, and cherishing moments with friends and family.
